Reposted by Yea-Lih Lin
I feel extremely honoured for this recognition. Thanks go to many people from my lab and colleagues for their trust and support over the years
👏 Prof. Maria-Elena Torres-Padilla, this year’s Leibniz Prize laureate, has now been honored with the Bavarian #Maximiliansorden for Science and Art.
👉 Read more: t1p.de/d5vq0
@metorrespadilla.bsky.social
@epihmgu.bsky.social
@pioneercampus.bsky.social
#StemCells #Epigenetics
👉 Read more: t1p.de/d5vq0
@metorrespadilla.bsky.social
@epihmgu.bsky.social
@pioneercampus.bsky.social
#StemCells #Epigenetics
December 4, 2025 at 8:39 AM
I feel extremely honoured for this recognition. Thanks go to many people from my lab and colleagues for their trust and support over the years
Reposted by Yea-Lih Lin
Data centres are energy hungry but what if we could use their waste heat to heat our homes?
That's exactly what happens in places like Finland: Cities are tapping the vast amounts of waste heat generated by data centres, and feeding it into district-heating networks.
That's exactly what happens in places like Finland: Cities are tapping the vast amounts of waste heat generated by data centres, and feeding it into district-heating networks.
December 3, 2025 at 11:20 AM
Data centres are energy hungry but what if we could use their waste heat to heat our homes?
That's exactly what happens in places like Finland: Cities are tapping the vast amounts of waste heat generated by data centres, and feeding it into district-heating networks.
That's exactly what happens in places like Finland: Cities are tapping the vast amounts of waste heat generated by data centres, and feeding it into district-heating networks.
Reposted by Yea-Lih Lin
Nature research paper: Shared and language-specific phonological processing in the human temporal lobe
go.nature.com/4r9HExe
go.nature.com/4r9HExe
Shared and language-specific phonological processing in the human temporal lobe - Nature
The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-specific sound sequences if the language is known.
go.nature.com
November 19, 2025 at 5:32 PM
Nature research paper: Shared and language-specific phonological processing in the human temporal lobe
go.nature.com/4r9HExe
go.nature.com/4r9HExe
Reposted by Yea-Lih Lin
Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!
November 14, 2025 at 4:03 PM
Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!
Reposted by Yea-Lih Lin
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
November 14, 2025 at 2:27 PM
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
Reposted by Yea-Lih Lin
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
A role for human senataxin in contending with pausing and backtracking during transcript elongation
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
www.sciencedirect.com
November 12, 2025 at 5:36 PM
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
Reposted by Yea-Lih Lin
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Reposted by Yea-Lih Lin
🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...
docs.google.com/spreadsheets...
DNA REPAIR/GENOME STABILITY CONFERENCES
docs.google.com
November 9, 2025 at 10:33 PM
🧬 List of 2026 DNA repair and genome stability conferences, now updated. Please let me know if there is anything missing!
docs.google.com/spreadsheets...
docs.google.com/spreadsheets...
Reposted by Yea-Lih Lin
Le génocide à travers leurs yeux: une chronologie illustrée de @972mag.com www.972mag.com/the-genocide...
The genocide through their eyes: An illustrated timeline - +972 Magazine
For two years, our team of journalists in Gaza illuminated what Israel sought to keep hidden, while enduring the very displacement, starvation, and loss that they reported on. This is what they saw.
www.972mag.com
November 7, 2025 at 12:45 PM
Le génocide à travers leurs yeux: une chronologie illustrée de @972mag.com www.972mag.com/the-genocide...
Reposted by Yea-Lih Lin
Let's go! Super excited to partner with @richardsever.bsky.social and the fantastic @openrxiv.bsky.social team - Preprints have been the best thing that happened to science publishing during my lifetime, and we're happy @qedscience.bsky.social can make preprints do more 👊
November 6, 2025 at 2:52 PM
Let's go! Super excited to partner with @richardsever.bsky.social and the fantastic @openrxiv.bsky.social team - Preprints have been the best thing that happened to science publishing during my lifetime, and we're happy @qedscience.bsky.social can make preprints do more 👊
Reposted by Yea-Lih Lin
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...
www.science.org
October 30, 2025 at 9:52 PM
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Yea-Lih Lin
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Yea-Lih Lin
Nature research paper: SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
go.nature.com/477I3sj
go.nature.com/477I3sj
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
go.nature.com
October 28, 2025 at 11:53 AM
Nature research paper: SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
go.nature.com/477I3sj
go.nature.com/477I3sj
Reposted by Yea-Lih Lin
H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
October 27, 2025 at 1:27 PM
H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
@penengolab.bsky.social and collaborators
www.embopress.org/doi/full/10....
Reposted by Yea-Lih Lin
Freaking go, science.
Go vaccines!
“The COVID-19 mRNA vaccine acts like a siren and activates the immune system throughout the entire body”, including inside the tumour, where it “starts programming a response to kill the cancer”
www.nature.com/articles/d41...
Go vaccines!
“The COVID-19 mRNA vaccine acts like a siren and activates the immune system throughout the entire body”, including inside the tumour, where it “starts programming a response to kill the cancer”
www.nature.com/articles/d41...
People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
www.nature.com
October 25, 2025 at 6:21 PM
Freaking go, science.
Go vaccines!
“The COVID-19 mRNA vaccine acts like a siren and activates the immune system throughout the entire body”, including inside the tumour, where it “starts programming a response to kill the cancer”
www.nature.com/articles/d41...
Go vaccines!
“The COVID-19 mRNA vaccine acts like a siren and activates the immune system throughout the entire body”, including inside the tumour, where it “starts programming a response to kill the cancer”
www.nature.com/articles/d41...
Reposted by Yea-Lih Lin
La bande-annonce de "Palestine 36", le film d'Annemarie Jacir, qui sera dans les salles en France en janvier 2026 youtu.be/14H4J8bewDY?...
PALESTINE 36 I Official US Trailer
YouTube video by Watermelon Pictures
youtu.be
October 25, 2025 at 3:41 PM
La bande-annonce de "Palestine 36", le film d'Annemarie Jacir, qui sera dans les salles en France en janvier 2026 youtu.be/14H4J8bewDY?...
Reposted by Yea-Lih Lin
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A nuclease-driven mechanism of post-replicative ssDNA gap suppression.
The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...
www.biorxiv.org
October 22, 2025 at 6:56 PM
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Yea-Lih Lin
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
fr.scribd.com/document/934...
Offer PhD Position Team Lambert | PDF | Genetics | Life Sciences
3-year PhD offer in biology to mechanisms of complex rearrangements of the genome.
fr.scribd.com
October 19, 2025 at 7:32 PM
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
fr.scribd.com/document/934...
Reposted by Yea-Lih Lin
Prix Nobel de génocide.
www.rtl.be/actu/monde/i...
www.rtl.be/actu/monde/i...
La nouvelle prix Nobel de la paix appelle Benjamin Netanyahu… et le félicite pour « ses actions durant la guerre »
La prix Nobel de la paix Maria Corina Machado salue le « courage » de Netanyahu face au totalitarisme, dénonçant l’axe Iran-Maduro-Hamas. Une prise de position qui ravive les tensions en Amérique lati...
www.rtl.be
October 18, 2025 at 10:43 AM
Prix Nobel de génocide.
www.rtl.be/actu/monde/i...
www.rtl.be/actu/monde/i...
Reposted by Yea-Lih Lin
Nature research paper: Population-specific polygenic risk scores for people of Han Chinese ancestry
go.nature.com/3WCMp4n
go.nature.com/3WCMp4n
Population-specific polygenic risk scores for people of Han Chinese ancestry - Nature
The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.
go.nature.com
October 16, 2025 at 10:34 AM
Nature research paper: Population-specific polygenic risk scores for people of Han Chinese ancestry
go.nature.com/3WCMp4n
go.nature.com/3WCMp4n
Reposted by Yea-Lih Lin
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Yea-Lih Lin
People can still be kind 👍 - great dispatch and pics from Helen Davidson www.theguardian.com/world/2025/o...
Gym bros, monks, retirees: thousands descend on Taiwan town to clean up after devastating flood
Trains packed with volunteers arrive at tourist town of Guangfu, days after typhoon sent millions of tonnes of mud and water crashing through its streets
www.theguardian.com
October 1, 2025 at 11:30 PM
People can still be kind 👍 - great dispatch and pics from Helen Davidson www.theguardian.com/world/2025/o...
Reposted by Yea-Lih Lin
DNAi: an open-source AI tool for unbiased DNA fiber analysis https://www.biorxiv.org/content/10.1101/2025.09.30.679603v1
October 2, 2025 at 1:17 PM
DNAi: an open-source AI tool for unbiased DNA fiber analysis https://www.biorxiv.org/content/10.1101/2025.09.30.679603v1
Reposted by Yea-Lih Lin
Great work from Michelle Wang’s group at Cornell exploring how RNAP II and associated R-loops act as intrinsic roadblocks during mechanical DNA unzipping. These findings have mechanistic implications for transcription–replication conflict.
rdcu.be/eILVd
rdcu.be/eILVd
RNA polymerase II is a polar roadblock to a progressing DNA fork
Nature Communications - Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the...
rdcu.be
September 30, 2025 at 12:10 AM
Great work from Michelle Wang’s group at Cornell exploring how RNAP II and associated R-loops act as intrinsic roadblocks during mechanical DNA unzipping. These findings have mechanistic implications for transcription–replication conflict.
rdcu.be/eILVd
rdcu.be/eILVd
Reposted by Yea-Lih Lin
I'm very happy to share this review, written with Dan Blears, on a new interpretation of promoter-proximal pausing in the context of a transcription checkpoint. We're not the only ones with these ideas, but they've not been sufficiently explored the way we do here: genesdev.cshlp.org/content/earl...
Transcription quality control at the promoter-proximal checkpoint
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
September 26, 2025 at 12:32 PM
I'm very happy to share this review, written with Dan Blears, on a new interpretation of promoter-proximal pausing in the context of a transcription checkpoint. We're not the only ones with these ideas, but they've not been sufficiently explored the way we do here: genesdev.cshlp.org/content/earl...