Bill Wuest
@wmwuest.bsky.social
GRA Distinguished Investigator & Chemistry Professor at Emory. Research leverages natural product total synthesis to combat bacteria/antibiotic resistance. Father, mentor, entrepreneur, Yankee/ND Irish fan. https://wuest.emorychem.science/
Looks like this worked. Solicitation is up and deadline was moved back 2 weeks. Nice job.
September 26, 2025 at 4:22 PM
Looks like this worked. Solicitation is up and deadline was moved back 2 weeks. Nice job.
Also worth pointing out the MIRA mechanism, which sounds closer to what was suggested - betting on the athlete not the proposal. With all the cuts I worry this program won’t be able to continue as intended or planned.
July 5, 2025 at 12:39 PM
Also worth pointing out the MIRA mechanism, which sounds closer to what was suggested - betting on the athlete not the proposal. With all the cuts I worry this program won’t be able to continue as intended or planned.
I believe nigms cancelled f31s awhile back.
June 14, 2025 at 2:17 PM
I believe nigms cancelled f31s awhile back.
I dont have that data (I think that med school accepts seem similar) but I do not think this 5 course sequence is THAT different that a normal 2 semester gen chem, 2 semester organic, quantum sequence, with a little biochem added. The bigger difference is the electives needed to be offered after.
May 29, 2025 at 4:57 PM
I dont have that data (I think that med school accepts seem similar) but I do not think this 5 course sequence is THAT different that a normal 2 semester gen chem, 2 semester organic, quantum sequence, with a little biochem added. The bigger difference is the electives needed to be offered after.
Nope not quite what we do. 1st semester is structure-focused (~95% gen chem), 2nd is 70/30 gen chem/orgo, focusing on equilibria mainly, 3rd is 100% orgo, 4th is ~50/50 orgo/biochem. 5th is p chem (quantum mostly). These are my own estimates but am fairly familiar with the curriculum.
May 29, 2025 at 4:38 PM
Nope not quite what we do. 1st semester is structure-focused (~95% gen chem), 2nd is 70/30 gen chem/orgo, focusing on equilibria mainly, 3rd is 100% orgo, 4th is ~50/50 orgo/biochem. 5th is p chem (quantum mostly). These are my own estimates but am fairly familiar with the curriculum.
I typically review all files twice a year (week before enrollment). I actually make this a lab job for a grad student aspiring to be pui faculty and they help organize and conduct the interviews too.
May 16, 2025 at 8:52 PM
I typically review all files twice a year (week before enrollment). I actually make this a lab job for a grad student aspiring to be pui faculty and they help organize and conduct the interviews too.
Oh I agree but I have found that by asking the right questions we can trim the number down to 4-5 then conduct brief zoom interviews to land on the best fits, at least imo. Success rate and long term retention have gone up and students really appreciate the clarity.
May 16, 2025 at 7:30 PM
Oh I agree but I have found that by asking the right questions we can trim the number down to 4-5 then conduct brief zoom interviews to land on the best fits, at least imo. Success rate and long term retention have gone up and students really appreciate the clarity.
Instead of relying on emails why not create an application form for anyone interested to complete? Then they won’t have to guess at what you are looking for & you can level the playing field for all. We have found this approach super useful in my lab! Happy to share more info if you are interested.
May 16, 2025 at 7:19 PM
Instead of relying on emails why not create an application form for anyone interested to complete? Then they won’t have to guess at what you are looking for & you can level the playing field for all. We have found this approach super useful in my lab! Happy to share more info if you are interested.
Ours at Emory is also happening.
May 13, 2025 at 4:32 PM
Ours at Emory is also happening.
I have that exact record in my office! I remember reading the background and finding it online.
April 26, 2025 at 9:32 PM
I have that exact record in my office! I remember reading the background and finding it online.
Yeah, they were very close to approval by a startup company (Phase 3 I think). However, the IPO to fund the trial was "shorted" by investors and ended up bankrupting the company. I believe Roche picked up the IP. It is sad how often this happens in ABX research....
April 22, 2025 at 3:51 PM
Yeah, they were very close to approval by a startup company (Phase 3 I think). However, the IPO to fund the trial was "shorted" by investors and ended up bankrupting the company. I believe Roche picked up the IP. It is sad how often this happens in ABX research....
What Stephan meant to say is no 🙂, him and I are on another paper together led by Stephan Sieber published in Nat Chem. It's really cool IMO: www.nature.com/articles/s41...
Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms - Nature Chemistry
Screening commercial kinase inhibitors for antibacterial activity identified the anticancer drug sorafenib as a major hit. Subsequent structure–activity optimization created a new antibacterial analog...
www.nature.com
April 22, 2025 at 3:49 PM
What Stephan meant to say is no 🙂, him and I are on another paper together led by Stephan Sieber published in Nat Chem. It's really cool IMO: www.nature.com/articles/s41...
I use this paper in my chem Bio class as well. So good! Crazy this compound hasn’t made it to the market imo.
April 22, 2025 at 10:27 AM
I use this paper in my chem Bio class as well. So good! Crazy this compound hasn’t made it to the market imo.
you and me both. i even got my RPPR in 8 weeks early and realized one journal put a 12 month embargo on them instead of the necessary 3.....ugh.
April 9, 2025 at 7:05 PM
you and me both. i even got my RPPR in 8 weeks early and realized one journal put a 12 month embargo on them instead of the necessary 3.....ugh.
I am getting very nervous about NIHMS service. If papers aren't uploaded there then grants can technically be withheld. The delay for NIHMS uploading has noticeably increased. Any word on this infrastructure??
April 9, 2025 at 6:57 PM
I am getting very nervous about NIHMS service. If papers aren't uploaded there then grants can technically be withheld. The delay for NIHMS uploading has noticeably increased. Any word on this infrastructure??
we are due for some wins, right? maybe? ugh.....
April 8, 2025 at 3:29 PM
we are due for some wins, right? maybe? ugh.....
Congrats Erin!! Well deserved!
April 4, 2025 at 1:02 AM
Congrats Erin!! Well deserved!