William Bakhache
@williambakhache.bsky.social
Post-doc @ Quantitative Virology and Evolution Unit, LVD, NIH -- http://qveu.bio -- Working on Enterovirus evolution
Reposted by William Bakhache
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication
Replication organelles of positive-sense RNA viruses are essential to virus biology, yet their molecular mechanisms remain poorly defined. While deep mutational scanning (DMS) measures the impact of m...
researchsquare.com
September 29, 2025 at 8:13 PM
New #QVEU preprint! @williambakhache.bsky.social used our #EV71 mutational scanning library to dissect replication complex function with a collection of inhibitors against specific host and viral factors. Then used the data to validate structural predictions! Super cool #virosky #virus #evolution
Reposted by William Bakhache
Excited to have this second paper out from the QVEU! Postdoc @williambakhache.bsky.social led this effort along with @orrwalk.bsky.social and Lauren McCormick to explore the tolerance of the Enterovirus EV-A71 to substitutions, insertions, and deletions. www.nature.com/articles/s41...
Deep mutation, insertion and deletion scanning across the Enterovirus A proteome reveals constraints shaping viral evolution - Nature Microbiology
Deep mutational scanning of Enterovirus A71 maps and quantifies the impact of genomic insertions, deletions and substitutions on virus fitness and highlights the role of insertions and deletions in th...
www.nature.com
November 28, 2024 at 12:55 PM
Excited to have this second paper out from the QVEU! Postdoc @williambakhache.bsky.social led this effort along with @orrwalk.bsky.social and Lauren McCormick to explore the tolerance of the Enterovirus EV-A71 to substitutions, insertions, and deletions. www.nature.com/articles/s41...