@Westermarcklab
@westermarcklab.bsky.social
#CIP2A and #Phosphatase biology for cancer therapy @TurkuBioscience @UniTurku
#PP2A #MYC #PME-1 #RAS #Breastcancer #TNBC #Epigenetics
https://bioscience.fi/research/cancer-cell-signaling
https://publons.com/researcher/3571657/jukka-westermarck/
#PP2A #MYC #PME-1 #RAS #Breastcancer #TNBC #Epigenetics
https://bioscience.fi/research/cancer-cell-signaling
https://publons.com/researcher/3571657/jukka-westermarck/
@srikarnagelli.bsky.social back on the crime scene. Always good to have alumni visiting the lab and sharing their new knowledge
October 31, 2025 at 9:55 AM
@srikarnagelli.bsky.social back on the crime scene. Always good to have alumni visiting the lab and sharing their new knowledge
Congrats @shrutibhardiya.bsky.social @westermarcklab.bsky.social for winning the best poster prize at 7th @fibtra.bsky.social annual Brain Tumor meeting. Excellent meeting, thanks to all organisers 💪
October 27, 2025 at 8:46 AM
Congrats @shrutibhardiya.bsky.social @westermarcklab.bsky.social for winning the best poster prize at 7th @fibtra.bsky.social annual Brain Tumor meeting. Excellent meeting, thanks to all organisers 💪
Very exciting talk by Alberto Ballestin on acute impact of surgery on glioblastoma tissue @fibtra.bsky.social annual symposium in Turku.
October 24, 2025 at 6:36 AM
Very exciting talk by Alberto Ballestin on acute impact of surgery on glioblastoma tissue @fibtra.bsky.social annual symposium in Turku.
#CIP2A has a druggable pocket. I am thrilled to announce that the last of my #CIP2A bucket list items, established 2007 has finally been accomplished. The work now out in BioRxiv reports a small molecule druggable pocket on CIP2A
1/2 www.biorxiv.org/content/10.1...
1/2 www.biorxiv.org/content/10.1...
Modulation of CIP2A dimerization and protein stability via druggable pocket
Cancerous inhibitor of PP2A (CIP2A) supports malignant growth across several cancer types. CIP2A is also a synthetic lethal therapy target for BRCA-mutant cancers. In addition, CIP2A causes Alzheimer'...
www.biorxiv.org
October 15, 2025 at 5:57 AM
#CIP2A has a druggable pocket. I am thrilled to announce that the last of my #CIP2A bucket list items, established 2007 has finally been accomplished. The work now out in BioRxiv reports a small molecule druggable pocket on CIP2A
1/2 www.biorxiv.org/content/10.1...
1/2 www.biorxiv.org/content/10.1...
Have you heard of #CIP2A, a hot new kid on the block of genome integrity and DNA repair?
Funny enough, most of these papers hardly mention CIP2A as PP2A inhibitor covered by about 400 papers. This is really exciting developments for sure, an eventually these oncogenic arms of CIP2A will merge.
Funny enough, most of these papers hardly mention CIP2A as PP2A inhibitor covered by about 400 papers. This is really exciting developments for sure, an eventually these oncogenic arms of CIP2A will merge.
October 14, 2025 at 1:20 PM
Have you heard of #CIP2A, a hot new kid on the block of genome integrity and DNA repair?
Funny enough, most of these papers hardly mention CIP2A as PP2A inhibitor covered by about 400 papers. This is really exciting developments for sure, an eventually these oncogenic arms of CIP2A will merge.
Funny enough, most of these papers hardly mention CIP2A as PP2A inhibitor covered by about 400 papers. This is really exciting developments for sure, an eventually these oncogenic arms of CIP2A will merge.
#careergoals after all these years I was finally rewarded by a whiteboard in my office.😁 Had to start using it immediately.
September 12, 2025 at 9:11 AM
#careergoals after all these years I was finally rewarded by a whiteboard in my office.😁 Had to start using it immediately.
Elias Tillandz Prize awarded at the BioCity Symposium to scientific publications on breast cancer recurrence and cancer gene overactivation www.utu.fi/en/news/pres...
Elias Tillandz Prize awarded at the BioCity Symposium to scientific publications on breast cancer recurrence and cancer gene overactivation
The Elias Tillandz prize for the best scientific publication of 2024 was presented for two groundbreaking cancer studies.
www.utu.fi
August 28, 2025 at 7:20 AM
Elias Tillandz Prize awarded at the BioCity Symposium to scientific publications on breast cancer recurrence and cancer gene overactivation www.utu.fi/en/news/pres...
Reposted by @Westermarcklab
August issue now online! ➡️ www.embopress.org/toc/17574684...
The cover highlights the study by X Qiao, J Routila, J Westermarck, S Ventelä & al @westermarcklab.bsky.social showing that LIMA1 detection can be used for #HNSCC patients stratification
Scientific image by M. Peltola, Thestra Oy, Turku
The cover highlights the study by X Qiao, J Routila, J Westermarck, S Ventelä & al @westermarcklab.bsky.social showing that LIMA1 detection can be used for #HNSCC patients stratification
Scientific image by M. Peltola, Thestra Oy, Turku
EMBO Molecular Medicine: Vol 17, No 8
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
August 11, 2025 at 2:54 PM
August issue now online! ➡️ www.embopress.org/toc/17574684...
The cover highlights the study by X Qiao, J Routila, J Westermarck, S Ventelä & al @westermarcklab.bsky.social showing that LIMA1 detection can be used for #HNSCC patients stratification
Scientific image by M. Peltola, Thestra Oy, Turku
The cover highlights the study by X Qiao, J Routila, J Westermarck, S Ventelä & al @westermarcklab.bsky.social showing that LIMA1 detection can be used for #HNSCC patients stratification
Scientific image by M. Peltola, Thestra Oy, Turku
We are on the cover! Or what is in the cover is way more important than we, it's evidence that simple IHC assay could be used for recognising #HNSCC patients based on their outcome after surgery-only therapy.
The actual cover and the article can be found here:
www.embopress.org/doi/full/10....
The actual cover and the article can be found here:
www.embopress.org/doi/full/10....
August 11, 2025 at 10:50 AM
We are on the cover! Or what is in the cover is way more important than we, it's evidence that simple IHC assay could be used for recognising #HNSCC patients based on their outcome after surgery-only therapy.
The actual cover and the article can be found here:
www.embopress.org/doi/full/10....
The actual cover and the article can be found here:
www.embopress.org/doi/full/10....
Particularly proud of this collaboration with Sami Ventela and all Finnish #HNSCC clinics revealing LIMA1-alpha as translatable biomarker for selection of HNSCC patients for surgery-only therapies.
www.utu.fi/en/news/pres...
www.embopress.org/doi/full/10....
www.utu.fi/en/news/pres...
www.embopress.org/doi/full/10....
New diagnostic breakthrough predicts which head and neck cancer patients can be cured with surgery alone
Researchers developed a diagnostic test based on the LIMA1-alpha protein to distinguish patients with head and neck squamous cell carcinoma who can be cured with surgery alone, without the need for
www.utu.fi
July 23, 2025 at 7:42 AM
Particularly proud of this collaboration with Sami Ventela and all Finnish #HNSCC clinics revealing LIMA1-alpha as translatable biomarker for selection of HNSCC patients for surgery-only therapies.
www.utu.fi/en/news/pres...
www.embopress.org/doi/full/10....
www.utu.fi/en/news/pres...
www.embopress.org/doi/full/10....
Very nice bioinformatics analysis of the role of #CIP2A in ovarian cancer by @karteris.bsky.social
rdcu.be/exid3
rdcu.be/exid3
Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer
Scientific Reports - Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer
rdcu.be
July 22, 2025 at 7:43 AM
Very nice bioinformatics analysis of the role of #CIP2A in ovarian cancer by @karteris.bsky.social
rdcu.be/exid3
rdcu.be/exid3
Lab cleaning day is one of the important @westermarcklab.bsky.social traditions. This year the after-cleaning pizzas were enjoyed in sunny Kupittaa park. Thanks Tiina for organization and everyone for your efforts
June 26, 2025 at 10:15 AM
Lab cleaning day is one of the important @westermarcklab.bsky.social traditions. This year the after-cleaning pizzas were enjoyed in sunny Kupittaa park. Thanks Tiina for organization and everyone for your efforts
Reposted by @Westermarcklab
Are you looking to start your #lab in a fantastic scientific 🧪environment, with great colleagues, and in a spectacular place to live?
Then check out our open #junior #faculty position at the Department of Oncology, University of Lausanne, Switzerland:
www.unil.ch/dof/en/home/...
⏰ Deadline 27 June
Then check out our open #junior #faculty position at the Department of Oncology, University of Lausanne, Switzerland:
www.unil.ch/dof/en/home/...
⏰ Deadline 27 June
June 23, 2025 at 5:14 PM
Are you looking to start your #lab in a fantastic scientific 🧪environment, with great colleagues, and in a spectacular place to live?
Then check out our open #junior #faculty position at the Department of Oncology, University of Lausanne, Switzerland:
www.unil.ch/dof/en/home/...
⏰ Deadline 27 June
Then check out our open #junior #faculty position at the Department of Oncology, University of Lausanne, Switzerland:
www.unil.ch/dof/en/home/...
⏰ Deadline 27 June
Reposted by @Westermarcklab
We’ve just marked a major milestone - our community of cancer researchers now numbers 14 000 members, working across 117 countries worldwide 🎉
Thank you to you, our members, for your ongoing support and commitment to advancing cancer research. Your passion and dedication inspire everything we do.
Thank you to you, our members, for your ongoing support and commitment to advancing cancer research. Your passion and dedication inspire everything we do.
June 23, 2025 at 9:20 AM
We’ve just marked a major milestone - our community of cancer researchers now numbers 14 000 members, working across 117 countries worldwide 🎉
Thank you to you, our members, for your ongoing support and commitment to advancing cancer research. Your passion and dedication inspire everything we do.
Thank you to you, our members, for your ongoing support and commitment to advancing cancer research. Your passion and dedication inspire everything we do.
Fantastic EACR @helloeacr.bsky.social annual congress in Lisbon. Great talks Great atmosphere Great to meet all old and new friends
June 18, 2025 at 3:40 PM
Fantastic EACR @helloeacr.bsky.social annual congress in Lisbon. Great talks Great atmosphere Great to meet all old and new friends
Lukijoilta | Tohtorintutkinto tulisi ottaa OKM:n ylimmän johdon pätevyysvaatimukseksi www.ts.fi/lukijoilta/6...
Lukijoilta | Tohtorintutkinto tulisi ottaa OKM:n ylimmän johdon pätevyysvaatimukseksi
OKM:n kansliapäällikön pätevyysvaatimusten korottaminen siten, että tiedepolitiikkaamme johdettaisiin vähintäänkin tohtoritutkinnon antaman tutkimuskokemuksen tuella, olisi mielipidekirjoittajien muka...
www.ts.fi
June 3, 2025 at 9:03 AM
Lukijoilta | Tohtorintutkinto tulisi ottaa OKM:n ylimmän johdon pätevyysvaatimukseksi www.ts.fi/lukijoilta/6...
Absolutely catapulting quadrable WEKK (Westermarck, Elenius, Kurppa, Kauko) retreat @Villa Wolax. Fantastic science, discussions, sauna, food, wine, colleagues @turkubioscience.bsky.social @medicity.bsky.social
June 2, 2025 at 6:22 PM
Absolutely catapulting quadrable WEKK (Westermarck, Elenius, Kurppa, Kauko) retreat @Villa Wolax. Fantastic science, discussions, sauna, food, wine, colleagues @turkubioscience.bsky.social @medicity.bsky.social
Want to relocate to Finland as a professor in the fields of basic, clinical, or translational medicine. An exciting funding opportunity. Please be on contact if I can be of any help.
www.sigridjuselius.fi/en/apurahat/...
www.sigridjuselius.fi/en/apurahat/...
Professorship (5 years) - Sigrid Jusélius Foundation
With the overall aim of supporting Finnish medical research to combat diseases that are devastating to humankind, the Sigrid Jusélius […]
www.sigridjuselius.fi
May 21, 2025 at 9:16 AM
Want to relocate to Finland as a professor in the fields of basic, clinical, or translational medicine. An exciting funding opportunity. Please be on contact if I can be of any help.
www.sigridjuselius.fi/en/apurahat/...
www.sigridjuselius.fi/en/apurahat/...
Reposted by @Westermarcklab
Early-stage, curiosity-driven cancer research is the cornerstone of future medical breakthroughs. Let's #KeepResearchCurious ✨
May 20, 2025 at 7:01 AM
Early-stage, curiosity-driven cancer research is the cornerstone of future medical breakthroughs. Let's #KeepResearchCurious ✨
New preprint from us.
The study led by Mukund Sharma demonstrates how #PP2A mediated dephosphorylation of serine 166 of LSD1 functions as a phosphorylation switch between gene repression and activation by LSD1 and how this shapes tumor microenvironment.
www.biorxiv.org/content/10.1...
The study led by Mukund Sharma demonstrates how #PP2A mediated dephosphorylation of serine 166 of LSD1 functions as a phosphorylation switch between gene repression and activation by LSD1 and how this shapes tumor microenvironment.
www.biorxiv.org/content/10.1...
May 18, 2025 at 2:57 PM
New preprint from us.
The study led by Mukund Sharma demonstrates how #PP2A mediated dephosphorylation of serine 166 of LSD1 functions as a phosphorylation switch between gene repression and activation by LSD1 and how this shapes tumor microenvironment.
www.biorxiv.org/content/10.1...
The study led by Mukund Sharma demonstrates how #PP2A mediated dephosphorylation of serine 166 of LSD1 functions as a phosphorylation switch between gene repression and activation by LSD1 and how this shapes tumor microenvironment.
www.biorxiv.org/content/10.1...
Very exciting program for the next year @helloeacr.bsky.social "Signaling Circuits in Cancer" virtual meeting just published.
Scientific programme | Signalling Circuits in Cancer | The European Association for Cancer Research url:https://eacr.org/conference/signallingcircuits2026/sc
Scientific programme | Signalling Circuits in Cancer | The European Association for Cancer Research url:https://eacr.org/conference/signallingcircuits2026/sc
May 16, 2025 at 8:12 AM
Very exciting program for the next year @helloeacr.bsky.social "Signaling Circuits in Cancer" virtual meeting just published.
Scientific programme | Signalling Circuits in Cancer | The European Association for Cancer Research url:https://eacr.org/conference/signallingcircuits2026/sc
Scientific programme | Signalling Circuits in Cancer | The European Association for Cancer Research url:https://eacr.org/conference/signallingcircuits2026/sc
Very important milestone for Finnish academic drug development. The recently established Finnish Drug Development Center has started its first drug development project in collaboration with a start-up Kohde Pharma. ddcenter.fi/kohde-pharma...
Kohde Pharma Oy Secures Investment from Finnish Drug Discovery Center Ltd - Finnish Drug Discovery Center
Vantaa, Finland – May 8th 2025 – Kohde Pharma Oy, a newly incorporated pharmaceutical company in Finland, is pleased to announce that it has secured its first investment from Finnish Drug Discovery Ce...
ddcenter.fi
May 8, 2025 at 10:27 AM
Very important milestone for Finnish academic drug development. The recently established Finnish Drug Development Center has started its first drug development project in collaboration with a start-up Kohde Pharma. ddcenter.fi/kohde-pharma...
Great news for European science
The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning.
👉 europa.eu/!NTYTTV
👉 europa.eu/!NTYTTV
Choose Europe for Science: ERC welcomes new budget for 'super grants'
The Scientific Council of the European Research Council welcomes the offer of substantial additional budget from the European Commission for the development of a new ERC funding instrument offering la...
europa.eu
May 6, 2025 at 10:12 AM
Great news for European science
Always great to see @westermarcklab.bsky.social alumni. This time very heartwarming breakfast with Melissa Junttila at #AACR2025
April 28, 2025 at 3:08 PM
Always great to see @westermarcklab.bsky.social alumni. This time very heartwarming breakfast with Melissa Junttila at #AACR2025
