Reposted by Jun
Deng, Thorn et al. @sydney.edu.au report that liprin-α1 is part of a glucose-regulated complex controlling the positioning of #insulin granule fusion, revealing a novel step in the mechanism of stimulus–secretion coupling. rupress.org/jcb/article/...
#CellSignaling #Physiology
#CellSignaling #Physiology
August 28, 2025 at 4:01 PM
Deng, Thorn et al. @sydney.edu.au report that liprin-α1 is part of a glucose-regulated complex controlling the positioning of #insulin granule fusion, revealing a novel step in the mechanism of stimulus–secretion coupling. rupress.org/jcb/article/...
#CellSignaling #Physiology
#CellSignaling #Physiology
Reposted by Jun
We're starting the "Night Science Seminar Series" where the notion is that as you talk about your science, as in a regular talk, there's is also a slide labeled “A Night Science Moment” to discuss how the idea came about. I'll go first on Sept 22 - Join us virtually!
cassyni.com/events/ApfsK...
cassyni.com/events/ApfsK...
August 24, 2025 at 1:28 AM
We're starting the "Night Science Seminar Series" where the notion is that as you talk about your science, as in a regular talk, there's is also a slide labeled “A Night Science Moment” to discuss how the idea came about. I'll go first on Sept 22 - Join us virtually!
cassyni.com/events/ApfsK...
cassyni.com/events/ApfsK...
Reposted by Jun
The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...
August 11, 2025 at 2:23 AM
The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...
All a worm researcher wants for Christmas:
June 1, 2025 at 10:46 AM
All a worm researcher wants for Christmas:
How I finally found my confidence as a scientist | Science | AAAS www.science.org/content/arti...
How I finally found my confidence as a scientist
After three postdoc positions, this researcher now sees her skills and knowledge as valuable
www.science.org
April 11, 2025 at 10:02 AM
How I finally found my confidence as a scientist | Science | AAAS www.science.org/content/arti...
Reposted by Jun
Big overview of more than a decade of hard work: NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
link.springer.com/article/10.1...
link.springer.com/article/10.1...
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse po...
A core facet of the National Institute on Aging’s mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part of the comprehensive effort toward th...
link.springer.com
April 7, 2025 at 6:05 PM
Big overview of more than a decade of hard work: NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Jun
I am excited to share that the project that taught me how to do science is now published at Journal of Cell Biology @jcb.org.
Pu Zhang @puzhang.bsky.social, Taylor Medwig-Kinney @tmedwigkinney.bsky.social, & colleagues from the Goldstein lab found that a population of Arp2/3 recruited to where cells touch each other makes an unexpected contribution to apical constriction rupress.org/jcb/article/...
March 11, 2025 at 8:16 PM
I am excited to share that the project that taught me how to do science is now published at Journal of Cell Biology @jcb.org.
Reposted by Jun
☕️Afonso et al. show that, during #anaphase, chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size, slowing in smaller cells, thereby scaling anaphase.
bit.ly/41k8XsG
bit.ly/41k8XsG
Cytoplasmic flow is a cell size sensor that scales anaphase - Nature Cell Biology
Afonso et al. show that, during anaphase, chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size, slowing in smaller cells, thereby...
bit.ly
March 4, 2025 at 10:35 PM
☕️Afonso et al. show that, during #anaphase, chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size, slowing in smaller cells, thereby scaling anaphase.
bit.ly/41k8XsG
bit.ly/41k8XsG
Reposted by Jun
What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...
February 2, 2025 at 11:51 AM
What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites M Alonso @albertpol.bsky.social and Harriet P Lo www.sciencedirect.com/science/arti...
Reposted by Jun
With how busy the start of the semester is, the #Worm25 organizers have announced an extension of the deadline to apply to organize a workshop at the conference!📣 You now have until January 31.
Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱
Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱
Workshop Applications - 25th International Worm Meeting
Visit our website to learn more.
buff.ly
January 17, 2025 at 9:01 PM
With how busy the start of the semester is, the #Worm25 organizers have announced an extension of the deadline to apply to organize a workshop at the conference!📣 You now have until January 31.
Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱
Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱
Reposted by Jun
December 26, 2024 at 5:07 PM
Reposted by Jun
It's that time of year. Confocal + Christmas = Xmas Tree, Ymas Tree, and our favorite Zmas tree. #microscopy #confocal #imaging
December 11, 2024 at 7:04 PM
It's that time of year. Confocal + Christmas = Xmas Tree, Ymas Tree, and our favorite Zmas tree. #microscopy #confocal #imaging
Reposted by Jun
C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions https://www.biorxiv.org/content/10.1101/2024.12.01.625591v1
C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions https://www.biorxiv.org/content/10.1101/2024.12.01.625591v1
Huntingtin (HTT) is the gene responsible for the Huntington disease (HD), a neurodegenerative disord
www.biorxiv.org
December 3, 2024 at 7:33 AM
C. elegans huntingtin, htt-1, promotes robust autophagy induction and survival under stress conditions https://www.biorxiv.org/content/10.1101/2024.12.01.625591v1
Reposted by Jun
Big thanks to @odedrechavi.bsky.social and @ethanewe.bsky.social for the Dispatch in @currentbiology.bsky.social on our amyloid inheritance paper. www.cell.com/current-biol...
Inheritance: Leaving sticky notes for the children
It is currently unknown to what degree parents’ life history can affect the next generation
and how such information might be transmitted. A new study finds that nematodes transmit
amyloid proteins to...
www.cell.com
December 2, 2024 at 4:10 PM
Big thanks to @odedrechavi.bsky.social and @ethanewe.bsky.social for the Dispatch in @currentbiology.bsky.social on our amyloid inheritance paper. www.cell.com/current-biol...
Reposted by Jun
🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook.
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons
The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...
journals.plos.org
November 26, 2024 at 11:38 PM
🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook.
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...
It's a big relief getting to know the C Elegans labs gotten funded downunder. Congratulations to them all!
November 26, 2024 at 11:00 PM
It's a big relief getting to know the C Elegans labs gotten funded downunder. Congratulations to them all!
Reposted by Jun
In my first real post I want to show the key experiment that revealed to me what I want my own lab to be about:
The conversion of phosphoinositides!
By using fluorescent biosensors and membrane coated beads I was able to reconstitute the real time kinetics of PI(4)P to PI(4,5)P2 conversion by PIP5K
The conversion of phosphoinositides!
By using fluorescent biosensors and membrane coated beads I was able to reconstitute the real time kinetics of PI(4)P to PI(4,5)P2 conversion by PIP5K
November 18, 2024 at 4:37 PM
In my first real post I want to show the key experiment that revealed to me what I want my own lab to be about:
The conversion of phosphoinositides!
By using fluorescent biosensors and membrane coated beads I was able to reconstitute the real time kinetics of PI(4)P to PI(4,5)P2 conversion by PIP5K
The conversion of phosphoinositides!
By using fluorescent biosensors and membrane coated beads I was able to reconstitute the real time kinetics of PI(4)P to PI(4,5)P2 conversion by PIP5K
Reposted by Jun
New study from Arantza Barrios' lab shows that valence of stimuli is flexibly encoded in the nervous system of C. elegans as they wiggle forward or backward... 🧪🪱
#neuroscience #behavior www.cell.com/current-biol...
#neuroscience #behavior www.cell.com/current-biol...
Conflict during learning reconfigures the neural representation of positive valence and approach behavior
How are positive and negative experiences integrated during learning? Here, Molina-García,
Colinas-Fischer, et al. find that the neuropeptide PDF-1 encodes both experiences
by being released from and ...
www.cell.com
November 14, 2024 at 7:19 PM
New study from Arantza Barrios' lab shows that valence of stimuli is flexibly encoded in the nervous system of C. elegans as they wiggle forward or backward... 🧪🪱
#neuroscience #behavior www.cell.com/current-biol...
#neuroscience #behavior www.cell.com/current-biol...