Vassilis Papalazarou
@vpapal.bsky.social
Biologist | Postdoctoral Fellow @labvousden.bsky.social
@crick.ac.uk
#Cancer #Metabolism #Metastasis
@crick.ac.uk
#Cancer #Metabolism #Metastasis
Reposted by Vassilis Papalazarou
I'm deeply honoured to receive the BACR/AstraZeneca Young Scientist Frank Rose Award in recognition of my cancer research.
Grateful to @thebacr.bsky.social @astra-zeneca.bsky.social #Mentors & #Colleagues whose support has shaped this journey.
My reflections👇
🔗 www.bacr.org.uk/news/2025-ba...
Grateful to @thebacr.bsky.social @astra-zeneca.bsky.social #Mentors & #Colleagues whose support has shaped this journey.
My reflections👇
🔗 www.bacr.org.uk/news/2025-ba...
July 15, 2025 at 8:15 AM
I'm deeply honoured to receive the BACR/AstraZeneca Young Scientist Frank Rose Award in recognition of my cancer research.
Grateful to @thebacr.bsky.social @astra-zeneca.bsky.social #Mentors & #Colleagues whose support has shaped this journey.
My reflections👇
🔗 www.bacr.org.uk/news/2025-ba...
Grateful to @thebacr.bsky.social @astra-zeneca.bsky.social #Mentors & #Colleagues whose support has shaped this journey.
My reflections👇
🔗 www.bacr.org.uk/news/2025-ba...
Exciting work, very happy to see it published! Huge congrats @gounismichalis.bsky.social and team! 😀
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 10, 2025 at 9:39 AM
Exciting work, very happy to see it published! Huge congrats @gounismichalis.bsky.social and team! 😀
Reposted by Vassilis Papalazarou
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 8:25 PM
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
Reposted by Vassilis Papalazarou
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:18 PM
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
Reposted by Vassilis Papalazarou
REVIEW | Kıvanç Birsoy, Monther Abu-Remaileh and colleagues @rockefelleruniv.bsky.social, @stanford.edu
The authors provide a broad overview of choline metabolism, its cellular handling, and how it impacts physiology and pathology.
https://bit.ly/3WPCPM2
The authors provide a broad overview of choline metabolism, its cellular handling, and how it impacts physiology and pathology.
https://bit.ly/3WPCPM2
Cellular and organismal function of choline metabolism - Nature Metabolism
bit.ly
February 7, 2025 at 4:00 PM
REVIEW | Kıvanç Birsoy, Monther Abu-Remaileh and colleagues @rockefelleruniv.bsky.social, @stanford.edu
The authors provide a broad overview of choline metabolism, its cellular handling, and how it impacts physiology and pathology.
https://bit.ly/3WPCPM2
The authors provide a broad overview of choline metabolism, its cellular handling, and how it impacts physiology and pathology.
https://bit.ly/3WPCPM2
Huge congrats Martha, well deserved!!! 🥳☺️
Honoured to be one of the first recipients of the EACR-Mark Foundation Postdoctoral Fellowship award to support my work on pancreatic cancer development at @labvousden.bsky.social @crick.ac.uk🥳
Thanks to everyone for the support during this journey!
Exciting research incoming 👩🔬👩🔬👩🔬
#womeninSTEM
Thanks to everyone for the support during this journey!
Exciting research incoming 👩🔬👩🔬👩🔬
#womeninSTEM
Congratulations to our first EACR-@themarkfdn Postdoctoral Fellowship winners! Julie Mazet, Christina Metoikidou and Martha Zarou 👏
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe.
magazine.eacr.org/congratulati...
This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe.
magazine.eacr.org/congratulati...
March 20, 2025 at 3:08 PM
Huge congrats Martha, well deserved!!! 🥳☺️
Reposted by Vassilis Papalazarou
🔔🧪 I'm deeply saddened by the passing of Michael Sheetz, a true pioneer in #mechanobiology.
I'll always cherish our lovely times in NYC, Singapore, Zurich, and Sydney. My heartfelt condolences to his family and friends in this difficult time.
So long, Mike 🥺😔
I'll always cherish our lovely times in NYC, Singapore, Zurich, and Sydney. My heartfelt condolences to his family and friends in this difficult time.
So long, Mike 🥺😔
February 3, 2025 at 9:00 AM
🔔🧪 I'm deeply saddened by the passing of Michael Sheetz, a true pioneer in #mechanobiology.
I'll always cherish our lovely times in NYC, Singapore, Zurich, and Sydney. My heartfelt condolences to his family and friends in this difficult time.
So long, Mike 🥺😔
I'll always cherish our lovely times in NYC, Singapore, Zurich, and Sydney. My heartfelt condolences to his family and friends in this difficult time.
So long, Mike 🥺😔
Reposted by Vassilis Papalazarou
Arp2/3 nucleates bidirectional linear actin filaments when activated by SPIN90 !!! www.biorxiv.org/content/10.1...
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers in metazoans
Branched actin networks nucleated by the Arp2/3 complex play critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90 fa...
www.biorxiv.org
January 31, 2025 at 2:31 PM
Arp2/3 nucleates bidirectional linear actin filaments when activated by SPIN90 !!! www.biorxiv.org/content/10.1...
Reposted by Vassilis Papalazarou
Our new imaging protocol in @natureportfolio.bsky.social provides a unique way to study metabolic interactions in the tumour microenvironment. #ImmunoSky
Read it here - rdcu.be/d7WGO
doi.org/10.1038/s415...
Thanks to my collaborators: @kreuzaler.bsky.social @crick.ac.uk
@cancergrand.bsky.social
Read it here - rdcu.be/d7WGO
doi.org/10.1038/s415...
Thanks to my collaborators: @kreuzaler.bsky.social @crick.ac.uk
@cancergrand.bsky.social
A multimodal imaging pipeline to decipher cell-specific metabolic functions and tissue microenvironment dynamics
Nature Protocols - Evaluating the metabolic organization of complex tissue microenvironments is useful for understanding cellular function within tissues. This protocol describes a multimodal...
rdcu.be
January 31, 2025 at 4:44 PM
Our new imaging protocol in @natureportfolio.bsky.social provides a unique way to study metabolic interactions in the tumour microenvironment. #ImmunoSky
Read it here - rdcu.be/d7WGO
doi.org/10.1038/s415...
Thanks to my collaborators: @kreuzaler.bsky.social @crick.ac.uk
@cancergrand.bsky.social
Read it here - rdcu.be/d7WGO
doi.org/10.1038/s415...
Thanks to my collaborators: @kreuzaler.bsky.social @crick.ac.uk
@cancergrand.bsky.social
Reposted by Vassilis Papalazarou
What is cancer and why is it so difficult to treat?
Crick group leader Gerard Evan explains why we get cancer and how he and other scientists are working to unravel this complex disease.
www.youtube.com/watch?v=i8gP...
Crick group leader Gerard Evan explains why we get cancer and how he and other scientists are working to unravel this complex disease.
www.youtube.com/watch?v=i8gP...
How Does Cancer Hack Our Cells? - with Gerard Evan
YouTube video by Francis Crick Institute
www.youtube.com
January 29, 2025 at 3:56 PM
What is cancer and why is it so difficult to treat?
Crick group leader Gerard Evan explains why we get cancer and how he and other scientists are working to unravel this complex disease.
www.youtube.com/watch?v=i8gP...
Crick group leader Gerard Evan explains why we get cancer and how he and other scientists are working to unravel this complex disease.
www.youtube.com/watch?v=i8gP...
Reposted by Vassilis Papalazarou
If the UK wants to lead in AI, it must fund more PhDs.
Or in medicine. Or in Chemistry. Or anything.
www.ft.com/content/a656...
Or in medicine. Or in Chemistry. Or anything.
www.ft.com/content/a656...
If the UK wants to lead in AI, it must fund more PhDs
Universities are the cornerstone of the country’s reputation as a global research hub but the business model is in crisis
www.ft.com
January 24, 2025 at 5:06 PM
If the UK wants to lead in AI, it must fund more PhDs.
Or in medicine. Or in Chemistry. Or anything.
www.ft.com/content/a656...
Or in medicine. Or in Chemistry. Or anything.
www.ft.com/content/a656...
Reposted by Vassilis Papalazarou
Our director Paul Nurse chatted to Robert Peston and Steph McGovern on The Rest is Money about science funding this week.
Paul discussed what it will take for the UK to become a ‘Science Superpower,’ as well as his story of discovering his own genetic history.
open.spotify.com/episode/6kxv...
Paul discussed what it will take for the UK to become a ‘Science Superpower,’ as well as his story of discovering his own genetic history.
open.spotify.com/episode/6kxv...
132. Why Britain Isn’t A “Science Superpower”
The Rest Is Money · Episode
open.spotify.com
January 24, 2025 at 10:43 AM
Our director Paul Nurse chatted to Robert Peston and Steph McGovern on The Rest is Money about science funding this week.
Paul discussed what it will take for the UK to become a ‘Science Superpower,’ as well as his story of discovering his own genetic history.
open.spotify.com/episode/6kxv...
Paul discussed what it will take for the UK to become a ‘Science Superpower,’ as well as his story of discovering his own genetic history.
open.spotify.com/episode/6kxv...
Reposted by Vassilis Papalazarou
This is always my favorite scientific event of the year! Super exciting science and the best vibes. Really looking forward to CMSW again this year :)
I’m really proud to announce the 2025 Cancer Metabolism Showcase and Workshop, May 5th and 6th, 9:30 AM - 3 PM EST. This year, our Keynote Speaker is Dr. Jeffrey Rathmell from VUMC.
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
I'm excited to come together, talk science, and support researchers in our field.
www.cancermetabolismshowcase.org
9:30 AM - 3 PM EST, May 5th and 6th, 2025
www.cancermetabolismshowcase.org
January 23, 2025 at 3:39 PM
This is always my favorite scientific event of the year! Super exciting science and the best vibes. Really looking forward to CMSW again this year :)
Reposted by Vassilis Papalazarou
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!
Looking forward to working with you!
January 23, 2025 at 8:37 AM
Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!
Looking forward to working with you!
Reposted by Vassilis Papalazarou
Congrats to Salma Merchant for Cell Stem Cell paper: the effects of fatty acid oxidation in hematopoietic stem cells are context dependent. FAO is not necessary in young HSCs, but becomes necessary during aging, and is deleterious when upregulated by a high fat diet.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet
Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.
www.cell.com
December 20, 2024 at 4:03 PM
Congrats to Salma Merchant for Cell Stem Cell paper: the effects of fatty acid oxidation in hematopoietic stem cells are context dependent. FAO is not necessary in young HSCs, but becomes necessary during aging, and is deleterious when upregulated by a high fat diet.
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Vassilis Papalazarou
I applaud this, and I had to do something similar recently. Don't forget, we are only humans
I took a break from work to protect my health. This should be more accepted in academia
www.science.org/content/arti...
I took a break from work to protect my health. This should be more accepted in academia
www.science.org/content/arti...
I took a break from work to protect my health. This should be more accepted in academia
Better support structures would “lead to a more inclusive, productive, and humane workplace for everyone,” this physician-scientist writes
www.science.org
December 20, 2024 at 6:06 PM
I applaud this, and I had to do something similar recently. Don't forget, we are only humans
I took a break from work to protect my health. This should be more accepted in academia
www.science.org/content/arti...
I took a break from work to protect my health. This should be more accepted in academia
www.science.org/content/arti...
Reposted by Vassilis Papalazarou
The sad realistion that someone will have to do experiments at some point....damn it
"The AI revolution is running out of data. What can researchers do?"
www.nature.com/articles/d41...
"The AI revolution is running out of data. What can researchers do?"
www.nature.com/articles/d41...
The AI revolution is running out of data. What can researchers do?
AI developers are rapidly picking the Internet clean to train large language models such as those behind ChatGPT. Here’s how they are trying to get around the problem.
www.nature.com
December 11, 2024 at 5:53 PM
The sad realistion that someone will have to do experiments at some point....damn it
"The AI revolution is running out of data. What can researchers do?"
www.nature.com/articles/d41...
"The AI revolution is running out of data. What can researchers do?"
www.nature.com/articles/d41...