Seychelle Vos
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voslab.org
Seychelle Vos
@voslab.org
I wrote an opinion piece for my hometown South Carolina newspaper that was published today. Support science funding for our future! Standing up for science today and always! tinyurl.com/mr3vuphr
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View the The Journal for Friday, March 7, 2025
tinyurl.com
March 7, 2025 at 12:31 PM
Reposted by Seychelle Vos
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
January 29, 2025 at 4:29 PM
The short talk abstract and scholarship deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation is tomorrow (23 January)! Get your abstracts in to be part of a great meeting in Banff this spring. @keystonesymposia.bsky.social keysym.us/KSChromatin25
January 22, 2025 at 7:21 PM
Reposted by Seychelle Vos
Only two days left to apply to the joint Epigenetics and Chromatin Architecture & Transcription Regulation meeting 👇 We're looking forward to seeing you in Banff!
The ⏰ is ticking to submit your abstract or scholarship application for a chance to present a short talk at our Epigenetics meeting. Make sure to send them in by 11:59 PM MST on January 9th!

keysym.us/KSEpigenetic...

#KSEpigenetics25 #epigenetics #humandevelopment #developmentalbiology
January 7, 2025 at 6:52 AM
Start off the New Year on a high note and submit your abstract for @KeystoneSymp Interplay of #Chromatin Architecture and #Transcription Regulation, this March/April in Banff. Short talk abstract and scholarship deadline are only 1 week away on January 9th! tinyurl.com/txn-keystone #KSChromatin25
KSQA: Dr. Seychelle M. Vos (Interplay of Chromatin Architecture)
YouTube video by KeystoneSymposia
www.youtube.com
January 2, 2025 at 8:07 PM
Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
The structural basis for RNA slicing by human Argonaute2
Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, showing that the slicing-competent conformation is achieved by domain movements and RNA-protein contacts distinct from those of conformational intermediates and prokaryotic homologs.
tinyurl.com
January 1, 2025 at 5:03 PM
Our paper describing a novel DNA binding mode for MORC2 is published! Congratulations to Nika Fendler on her first, first author paper. This was an epic effort and revealed many new and unpredicted functions for MORC2. You can read about it here: tinyurl.com/MORC2-DNA
December 31, 2024 at 3:23 PM
The short talk abstract deadline for the Keystone Interplay of Chromatin Architecture and Transcription Regulation meeting is coming up (Jan 9). The meeting is being held jointly with the Epigenetics in Development and Disease meeting. Join us in Banff for some awesome science. #KSChromatin25
November 21, 2024 at 5:06 PM