Vita Sukonthamarn
@vita-ps.bsky.social
PhD student in Human Genomics and Evolution @SVIMR. A Thai in Melbourne, interested in genetic variation influenced immune response in human and animals 🦠🧬
Reposted by Vita Sukonthamarn
Bird flu vaccine protects chickens and zoo birds
Prime-boost vaccination with RNA replicon particles protects multiple avian species, including 23 zoo bird species, from #H5N1 avian #influenza virus
#vaccines #flu
Prime-boost vaccination with RNA replicon particles protects multiple avian species, including 23 zoo bird species, from #H5N1 avian #influenza virus
#vaccines #flu
RNA replicon vaccination confers long-lasting protection against H5N1 avian influenza in 23 zoo bird species - Nature Communications
Highly pathogenic avian influenza H5N1 viruses cause mass mortality in birds and have infected over 50 mammalian species, including humans. Here, the authors report the use of a propagation-defective vesicular stomatitis virus replicon vaccine in captive birds, which provides protection against lethal H5N1 challenge.
bit.ly
November 17, 2025 at 3:28 PM
Bird flu vaccine protects chickens and zoo birds
Prime-boost vaccination with RNA replicon particles protects multiple avian species, including 23 zoo bird species, from #H5N1 avian #influenza virus
#vaccines #flu
Prime-boost vaccination with RNA replicon particles protects multiple avian species, including 23 zoo bird species, from #H5N1 avian #influenza virus
#vaccines #flu
Reposted by Vita Sukonthamarn
PhD student Kezia Gitareja is studying a new way to stop multiple myeloma, a type of blood cancer that affects the cells in our bone marrow.
Find out how Kezia is working to shut down cancer's protein factories: www.svi.edu.au/news-events/...
Find out how Kezia is working to shut down cancer's protein factories: www.svi.edu.au/news-events/...
November 18, 2025 at 3:02 AM
PhD student Kezia Gitareja is studying a new way to stop multiple myeloma, a type of blood cancer that affects the cells in our bone marrow.
Find out how Kezia is working to shut down cancer's protein factories: www.svi.edu.au/news-events/...
Find out how Kezia is working to shut down cancer's protein factories: www.svi.edu.au/news-events/...
Reposted by Vita Sukonthamarn
Seahorses have a unique sex role reversal with male pregnancy involving a brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellular basis and molecular mechanism of pouch development and diversity 🧪 www.nature.com/articles/s41...
Cellular and molecular mechanisms of seahorse male pregnancy - Nature Ecology & Evolution
Seahorses have a unique sex role reversal with male pregnancy involving the brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellu...
www.nature.com
November 17, 2025 at 8:52 AM
Seahorses have a unique sex role reversal with male pregnancy involving a brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellular basis and molecular mechanism of pouch development and diversity 🧪 www.nature.com/articles/s41...
Reposted by Vita Sukonthamarn
A Review in Nature Reviews Genetics examines the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention. 🔒
Clinical use of polygenic risk scores: current status, barriers and future directions - Nature Reviews Genetics
This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.
go.nature.com
November 14, 2025 at 11:39 PM
A Review in Nature Reviews Genetics examines the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention. 🔒
Reposted by Vita Sukonthamarn
Selection and transmission of the gut #microbiome alone, without changes in the host genome, can shift mammalian behaviour
(in mice)
@microbiome.bsky.social
(in mice)
@microbiome.bsky.social
Selection and transmission of the gut microbiome alone can shift mammalian behavior - Nature Communications
Here, the authors present evidence that the gut microbiome alone, without changes in the host genome, can shape how animals respond to selection, identifying a bacterium and its metabolite that independently reduce mouse locomotion.
bit.ly
November 14, 2025 at 4:02 PM
Selection and transmission of the gut #microbiome alone, without changes in the host genome, can shift mammalian behaviour
(in mice)
@microbiome.bsky.social
(in mice)
@microbiome.bsky.social
Reposted by Vita Sukonthamarn
Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social
Nature research paper: Convergent genome evolution shaped the emergence of terrestrial animals
go.nature.com/4i0i61w
go.nature.com/4i0i61w
Convergent genome evolution shaped the emergence of terrestrial animals - Nature
Comparisons of 154 genomes from 21 animal phyla and outgroups have been used to reconstruct ancestral adaptation to life on land across 11 distinct terrestrialization events, revealing strong evidence for convergent genomic evolution across the animal kingdom and recurring periods of terrestrial colonization.
go.nature.com
November 13, 2025 at 3:18 PM
Happy to share Jialin's first publication. She did a great job exploring the transition to land in animals. Co-supervised by the great Jordi Paps and me and in collaboration with Davide Pisani and @phil-donoghue.bsky.social
Reposted by Vita Sukonthamarn
Scientists studying the fat-tailed dunnart, a tiny Australian marsupial, have uncovered genetic clues that explain how different mammals develop their facial features.
Find out more: www.svi.edu.au/news-events/...
Find out more: www.svi.edu.au/news-events/...
November 13, 2025 at 5:08 AM
Scientists studying the fat-tailed dunnart, a tiny Australian marsupial, have uncovered genetic clues that explain how different mammals develop their facial features.
Find out more: www.svi.edu.au/news-events/...
Find out more: www.svi.edu.au/news-events/...
Reposted by Vita Sukonthamarn
this looks very interesting with numerous implications for nuclear biology and gene expression.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 9, 2025 at 5:07 PM
this looks very interesting with numerous implications for nuclear biology and gene expression.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Reposted by Vita Sukonthamarn
Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago.
Our new Focus Issue curates reviews and research in the field of Trained Immunity.
buff.ly/OoqVRjM
Our new Focus Issue curates reviews and research in the field of Trained Immunity.
buff.ly/OoqVRjM
November 9, 2025 at 9:21 AM
Innate immunity was long thought to be devoid of immunological memory until a landmark study a decade ago.
Our new Focus Issue curates reviews and research in the field of Trained Immunity.
buff.ly/OoqVRjM
Our new Focus Issue curates reviews and research in the field of Trained Immunity.
buff.ly/OoqVRjM
Reposted by Vita Sukonthamarn
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Reposted by Vita Sukonthamarn
🧵 Our latest preprint is available.
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
Multi-lineage natural gene therapy mediated by embryonic triploid mosaicism in the context of Fanconi anaemia
Fanconi anemia is a rare inherited bone marrow failure syndrome caused by inactivation of genes in the Fanconi anemia/BRCA DNA repair pathway. We report a patient with X-linked Fanconi anemia, and aty...
www.medrxiv.org
November 7, 2025 at 1:54 AM
🧵 Our latest preprint is available.
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
Reposted by Vita Sukonthamarn
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
November 4, 2025 at 2:10 AM
The remarkably long lifespan of bowhead whales could be due to an increased ability to repair DNA mutations, according to research in Nature. go.nature.com/4hzvDN7 🌏 🧪
Reposted by Vita Sukonthamarn
🧵🧵 MPOX
1/9
Three cases of Mpox Clade 1 confirmed in Los Angeles this month, none with recent foreign travel.
That suggests *local spread* is happening.
People here already have it and have transmitted it.
This is concerning - let’s delve in.
(Marathon post ahead!)
1/9
Three cases of Mpox Clade 1 confirmed in Los Angeles this month, none with recent foreign travel.
That suggests *local spread* is happening.
People here already have it and have transmitted it.
This is concerning - let’s delve in.
(Marathon post ahead!)
A potentially more severe strain of mpox may be spreading in L.A. County
It’s the first time this particular type of mpox, known as “Clade I,” has been found in the United States among people who had no history of traveling overseas to high-risk areas.
www.latimes.com
October 24, 2025 at 3:47 AM
🧵🧵 MPOX
1/9
Three cases of Mpox Clade 1 confirmed in Los Angeles this month, none with recent foreign travel.
That suggests *local spread* is happening.
People here already have it and have transmitted it.
This is concerning - let’s delve in.
(Marathon post ahead!)
1/9
Three cases of Mpox Clade 1 confirmed in Los Angeles this month, none with recent foreign travel.
That suggests *local spread* is happening.
People here already have it and have transmitted it.
This is concerning - let’s delve in.
(Marathon post ahead!)
Reposted by Vita Sukonthamarn
Fiji makes history!
In a landmark public health achievement, Fiji has been validated by WHO for eliminating trachoma as a public health problem.
✅ Trachoma — a neglected tropical disease (NTD) and the world’s leading infectious cause of blindness — is the first NTD to be eliminated in Fiji.
In a landmark public health achievement, Fiji has been validated by WHO for eliminating trachoma as a public health problem.
✅ Trachoma — a neglected tropical disease (NTD) and the world’s leading infectious cause of blindness — is the first NTD to be eliminated in Fiji.
October 20, 2025 at 5:53 AM
Fiji makes history!
In a landmark public health achievement, Fiji has been validated by WHO for eliminating trachoma as a public health problem.
✅ Trachoma — a neglected tropical disease (NTD) and the world’s leading infectious cause of blindness — is the first NTD to be eliminated in Fiji.
In a landmark public health achievement, Fiji has been validated by WHO for eliminating trachoma as a public health problem.
✅ Trachoma — a neglected tropical disease (NTD) and the world’s leading infectious cause of blindness — is the first NTD to be eliminated in Fiji.
Reposted by Vita Sukonthamarn
ICYMI: New online! Clinical use of polygenic risk scores: current status, barriers and future directions
Clinical use of polygenic risk scores: current status, barriers and future directions
Nature Reviews Genetics, Published online: 10 October 2025; doi:10.1038/s41576-025-00900-8This article reviews the current state of implementation of polygenic risk scores in the clinical setting, highlights key challenges and outlines future directions for the use of such scores to improve disease risk prediction and to enable personalized prevention.
www.nature.com
October 17, 2025 at 11:59 AM
ICYMI: New online! Clinical use of polygenic risk scores: current status, barriers and future directions
Reposted by Vita Sukonthamarn
🎉 New preprint out!
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
October 16, 2025 at 9:16 PM
🎉 New preprint out!
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
"Removing genetic effects on plasma proteins enhances their utility as disease biomarkers"
We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease
👉 doi.org/10.1101/2025...
Reposted by Vita Sukonthamarn
science is nice, huh.
Scientists Are Working on an Mrna Vaccine To Wipe Out Allergies
Researchers from the University of Pennsylvania may have developed a vaccine for seasonal allergies and food allergies.
www.vice.com
October 15, 2025 at 11:28 AM
science is nice, huh.
Reposted by Vita Sukonthamarn
My non-MPRA phd work! 😄
New, from @navya-shukla.bsky.social and me:
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
Lift&Add - rapid and robust addition of new species to alignments of conserved non-coding sequences https://www.biorxiv.org/content/10.1101/2025.10.14.682260v1
October 15, 2025 at 10:49 PM
My non-MPRA phd work! 😄
Reposted by Vita Sukonthamarn
Lift&Add - rapid and robust addition of new species to alignments of conserved non-coding sequences https://www.biorxiv.org/content/10.1101/2025.10.14.682260v1
October 15, 2025 at 6:33 PM
Lift&Add - rapid and robust addition of new species to alignments of conserved non-coding sequences https://www.biorxiv.org/content/10.1101/2025.10.14.682260v1
Reposted by Vita Sukonthamarn
New, from @navya-shukla.bsky.social and me:
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
Lift&Add - rapid and robust addition of new species to alignments of conserved non-coding sequences https://www.biorxiv.org/content/10.1101/2025.10.14.682260v1
October 15, 2025 at 9:43 PM
New, from @navya-shukla.bsky.social and me:
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
You have a new genome and want to test it for acceleration against other genomes:
Tired: add it to an existing WGA with much toil and tears
Wired: use our new approach to only add conserved regions!
🧬🧪🖥️
Reposted by Vita Sukonthamarn
Elephant endotheliotropic herpesvirus (EEHV) hemorrhagic disease is a significant cause of calf and juvenile mortality in Asian elephants. A paper in Nature Communications reports on a trial that evaluated the safety and immunogenicity of a vaccine against EEHV. go.nature.com/4omObTi 🧪
A safe, T cell-inducing heterologous vaccine against elephant endotheliotropic herpesvirus in a proof-of-concept study - Nature Communications
Elephant endotheliotropic herpesvirus (EEHV) haemorrhagic disease is a major threat for juvenile Asian elephants. This study reports a proof-of-concept trial that evaluates the safety and immunogenicity of a vaccine against EEHV.
go.nature.com
October 14, 2025 at 3:41 PM
Elephant endotheliotropic herpesvirus (EEHV) hemorrhagic disease is a significant cause of calf and juvenile mortality in Asian elephants. A paper in Nature Communications reports on a trial that evaluated the safety and immunogenicity of a vaccine against EEHV. go.nature.com/4omObTi 🧪
Reposted by Vita Sukonthamarn
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
October 13, 2025 at 12:55 PM
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
Reposted by Vita Sukonthamarn
Schall & @jeffreymkidd.bsky.social characterized structural variation in dogs using a combination of long- and short-read data and genome assemblies. Several SVs have frequency profiles across breeds consistent with selection.
🔗 doi.org/10.1093/gbe/evaf173
#genome #evolution #TEsky
🔗 doi.org/10.1093/gbe/evaf173
#genome #evolution #TEsky
October 2, 2025 at 8:34 AM
Schall & @jeffreymkidd.bsky.social characterized structural variation in dogs using a combination of long- and short-read data and genome assemblies. Several SVs have frequency profiles across breeds consistent with selection.
🔗 doi.org/10.1093/gbe/evaf173
#genome #evolution #TEsky
🔗 doi.org/10.1093/gbe/evaf173
#genome #evolution #TEsky
Reposted by Vita Sukonthamarn
Jane Goodall has died at the age of 91.
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
October 1, 2025 at 7:13 PM
Jane Goodall has died at the age of 91.
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
In 2020, Goodall spoke with Science Editor-in-Chief H. Holden Thorp for a #ScienceEditorial reflecting on the 60th anniversary of her arrival in Gombe to study wild chimpanzees. Read more: https://scim.ag/472Chb8
Reposted by Vita Sukonthamarn
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 24, 2025 at 3:12 PM
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
www.nature.com/articles/s41...