Vikas Yadav
@vikasyadavsci.bsky.social
Molecular microbiologist studying fungal genome dynamics, cell biology, and pathogenicity using Cryptococcus.
Senior Research Associate at Duke. Alumnus of JNCASR, India.
https://scholars.duke.edu/person/vikas.yadav
Senior Research Associate at Duke. Alumnus of JNCASR, India.
https://scholars.duke.edu/person/vikas.yadav
A big thanks to your efforts for freezing those isolates and support for the past few months.
May 24, 2025 at 5:04 PM
A big thanks to your efforts for freezing those isolates and support for the past few months.
Finally, this marks a significant advancement and description of a protein complex that is essential for high-temperature growth in a critical human fungal pathogen.
February 21, 2025 at 4:58 PM
Finally, this marks a significant advancement and description of a protein complex that is essential for high-temperature growth in a critical human fungal pathogen.
Using genetics, we then found that they indeed are interdependent on each other, and alphafold modeling showed a nice complex formation as well.
February 21, 2025 at 4:12 PM
Using genetics, we then found that they indeed are interdependent on each other, and alphafold modeling showed a nice complex formation as well.
As we looked at these in more depth, things started to become clearer, and we found that they were all involved in cell division. A deep dive into the literature revealed they were all part of a single complex that regulates cytokinesis in Saccharomyces cerevisiae. Huge thanks for all this work!
February 21, 2025 at 4:12 PM
As we looked at these in more depth, things started to become clearer, and we found that they were all involved in cell division. A deep dive into the literature revealed they were all part of a single complex that regulates cytokinesis in Saccharomyces cerevisiae. Huge thanks for all this work!
I then obtained >50 additional isolates and sequenced all of them. Interestingly enough, We kept on finding dominant amino acid change mutations in three proteins that did not seem related to each other in any way at first glance.
February 21, 2025 at 4:12 PM
I then obtained >50 additional isolates and sequenced all of them. Interestingly enough, We kept on finding dominant amino acid change mutations in three proteins that did not seem related to each other in any way at first glance.
This story in some way started >30 years ago when Joe and Audrey Odom, an undergrad at that time in the lab, isolated some mutants that were resistant to calcineurin inhibitors. A dozen of these were frozen and forgotten until about a couple of years ago when I revived and sequenced them.
February 21, 2025 at 4:12 PM
This story in some way started >30 years ago when Joe and Audrey Odom, an undergrad at that time in the lab, isolated some mutants that were resistant to calcineurin inhibitors. A dozen of these were frozen and forgotten until about a couple of years ago when I revived and sequenced them.