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vgijndsuao.bsky.social
@vgijndsuao.bsky.social
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Reposted
veeninglab.com
Really cool paper from @vincentdebakker.bsky.social @jonbakerlab.bsky.social now published @natcomms.nature.com #MicroSky www.nature.com/articles/s41...
Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae - Nature Communications
The pathogen Streptococcus pneumoniae can adapt to diverse microenvironments in the human body. Here, De Bakker et al. study these adaptation responses, showing unusual sugar utilization and identifyi...
www.nature.com
November 25, 2025 at 1:44 PM
Reposted
natcellbio.nature.com
☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events.
bit.ly/4oHxUZp
A continuous totipotent-like cell-based embryo model recapitulates mouse embryogenesis from zygotic genome activation to gastrulation - Nature Cell Biology
The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...
bit.ly
November 15, 2025 at 8:17 PM
Reposted
scverse.bsky.social
scCellFie is a computational framework that infers metabolic activities from both single-cell and spatial transcriptomic data, enabling large-scale, interpretable analyses across cell atlases.
November 10, 2025 at 3:16 PM
Reposted
labliston.bsky.social
Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...
A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation
Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...
www.medrxiv.org
June 21, 2025 at 11:29 AM
Reposted
lisago.bsky.social
Notes on a compelling discussion with @tsanglab.bsky.social

Genome = blueprint.
Immunome = real-time sensor.
The "curse of dimensionality" (millions of data points per sample!) meets AI compression.

Result? We can finally map the human immune system at scale.

@humanimmunomeproject 🚀
October 14, 2025 at 11:14 PM
Reposted
labwaggoner.bsky.social
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
November 6, 2025 at 2:48 AM
Reposted
immunoboys.bsky.social
Tracking antigen-specific CD8 T cells in the 🐭 intestine during LCMV infection over time: Trm precursors are found more in the base of villi, while mature Trm cells are found at the top of the villi, driven by TFGb.
@reinacampos.bsky.social &al 2025 in Nature
www.nature.com/articles/s41...
April 2, 2025 at 7:11 PM
Reposted
nathumbehav.nature.com
Qi et al. reveal that the brain encodes complex movement sequences as series of temporal states, each corresponding to a small movement fragment, with motor cortex neurons dynamically altering their encoding across states.
https://www.nature.c...
April 2, 2025 at 9:57 PM
Reposted
cyrilpedia.bsky.social
'Unexpectedly, we found the pronounced enrichment for RBPJ as a novel negative regulator of iTreg differentiation and FOXP3 expression with minimal effects in nTreg cells, highlighting the dependence on contextual cues and diverse avenues of #FOXP3 gene regulation'
#Immunology #Treg #Immunosky
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3 - Nature
The RBPJ–NCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T cells.
www.nature.com
April 2, 2025 at 10:02 PM
Reposted
erictopol.bsky.social
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @nature.com
www.nature.com/articles/d41...
nature.com/articles/s41...
A natural experiment on the effect of herpes zoster vaccination on dementia - Nature
Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...
nature.com
April 2, 2025 at 3:29 PM
Reposted
labwaggoner.bsky.social
Reconstitution of CXCR3+ CCR6+ Th17.1-Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1002/...
April 2, 2025 at 2:37 AM
Reposted
erictopol.bsky.social
How can B cells rapidly proliferate and have mutations suppressed? A longstanding mystery solved involving transient mutation suppression capability of germinal centers
nature.com/articles/s41...
www.nature.com/articles/s41...
Regulated somatic hypermutation enhances antibody affinity maturation - Nature
Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.
nature.com
March 19, 2025 at 7:56 PM
Reposted
jonykipnis.bsky.social
Beautiful paper in how meningeal immunity affects brain funciton via IFNg and inhibitory neurons… Yes, I LOVE when our findings are reproduced in completely independent settings 🤩 || www.cell.com/neuron/fullt...
Meningeal neutrophil immune signaling influences behavioral adaptation following threat
Wu et al. demonstrate how neutrophils, located within the protective layers of the brain, respond to social threats and modulate psychological processes. This process is governed by testosterone in a ...
www.cell.com
November 18, 2024 at 10:38 PM
Reposted
nature.com
A Microsoft researcher today presented results behind the company’s controversial claim last month to have created the first ‘topological’ qubits — a long-sought goal of quantum computing.

https://go.nature.com/4hjqUh8
Microsoft quantum computing claim still lacks evidence: physicists are dubious
Some attendees of a packed presentation were curious about the prospect of the first ‘topological’ qubits, but left with questions unanswered.
go.nature.com
March 18, 2025 at 10:43 PM
Reposted
elimereu.bsky.social
🚀 New Preprint Alert! 🚀 With the Standards and Technology Working Group of the @humancellatlas.org, we present a new preprint guiding multimodal #singlecell data integration and human organ atlas generation! 📄
Read the preprint: www.biorxiv.org/content/10.1...
Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.
The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...
www.biorxiv.org
March 7, 2025 at 9:54 AM
Reposted
elimereu.bsky.social
✅ Introducing #scOMM, a new interpretable machine learning tool for multimodal cell-type classification & benchmarking.

github.com/mereulab/scOMM
GitHub - mereulab/scOMM: Source code for scOMM
Source code for scOMM. Contribute to mereulab/scOMM development by creating an account on GitHub.
github.com
March 7, 2025 at 9:54 AM
Reposted
erictopol.bsky.social
Just published @science.org
A basis—lung inflammation—for #LongCovid (PASC) in the experimental model, and a potential therapy
[driven by alveolar macrophages and loss of their peroxisomes (Figure)]
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
graphic depicts that lung alveolar macrophages loss of peroxisome drives the process
March 6, 2025 at 7:00 PM
Reposted
teorth.bsky.social
I am happy to announce that the Kakeya set conjecture, one of the most sought after open problems in geometric measure theory, has now been proven (in three dimensions) by Hong Wang and Joshua Zahl! arxiv.org/abs/2502.17655 I discuss some ideas of the proof at terrytao.wordpress.com/2025/02/25/t...
Volume estimates for unions of convex sets, and the Kakeya set conjecture in three dimensions
We study sets of $δ$ tubes in $\mathbb{R}^3$, with the property that not too many tubes can be contained inside a common convex set $V$. We show that the union of tubes from such a set must have almos...
arxiv.org
February 26, 2025 at 4:49 AM
Reposted
vitaliikl.bsky.social
Cell2fate learns which genes have co-regulated transcription rates => spatially mapping velocity modules & improved robustness. Bayesian modelling => easier to add biological realism.

Exciting collab with Alexander Aivasidis in Bayraktar & @steglelab.bsky.social

www.nature.com/articles/s41...
Fig 4.
March 4, 2025 at 11:34 PM
Reposted
natureportfolio.nature.com
Aspirin may enhance the immune response against cancer metastasis in mice, according to research published in Nature. The authors suggest that the findings could aid the development of effective anti-metastatic immunotherapies. https://go.nature.com/3F3GWOB 🧪
This is figure 5, which shows that aspirin promotes anti-metastatic immunity by releasing T cells from ARHGEF1-dependent suppression by TXA2.
March 5, 2025 at 11:32 PM
Reposted
erictopol.bsky.social
Single-cell RNA sequencing of immune cells for over 1,000 people age 18-97 years. A clock of our immune system aging. Tells us about an individual's response to infection, vaccination, Long Covid. Towards an immunome.
www.nature.com/articles/s43...
March 5, 2025 at 2:53 PM
Reposted
aliciao.bsky.social
Pleased to present our CITE-seq paper analysing 45 BAL samples from (un)treated children with CF and controls. BAL is a tricky tissue, 44 celltypes dominated by macrophages. Trailblazing analysis led by @jovmaksimovic.bsky.social @melanieneeland.bsky.social @shivanthans.bsky.social and collaborators
medrxivpreprint.bsky.social medRxivpreprint @medrxivpreprint.bsky.social · Feb 27
Single-cell atlas of BAL from preschool cystic fibrosis reveals key inflammatory pathways modified by the CFTR modulator ivacaftor in the early life lung. https://www.medrxiv.org/content/10.1101/2025.02.24.25322508v1
March 1, 2025 at 3:40 AM
Reposted
biorxiv-immuno.bsky.social
Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis https://www.biorxiv.org/content/10.1101/2025.02.25.640192v1
March 1, 2025 at 8:15 PM
Reposted
natbiotech.nature.com
mRNA with engineered poly(A) tails produces prolonged higher levels of protein go.nature.com/3PzhhzM
rdcu.be/ebqSg
Branched chemically modified poly(A) tails enhance the translation capacity of mRNA - Nature Biotechnology
mRNA with engineered poly(A) tails produces prolonged higher levels of protein.
go.nature.com
February 27, 2025 at 3:05 AM
Reposted
natureportfolio.nature.com
A study in Nature Metabolism shows that short-term overeating with calorie-rich snacks disrupts insulin action in the brain of men, which outlasted the time-frame of overeating. https://go.nature.com/41fgHvT #NutSky 🧪
This is figure 2, which shows disrupted brain insulin action after short-term overeating with calorie-rich snacks.
February 25, 2025 at 2:47 PM