Valeria Robleto, PhD
@valeriarobleto.bsky.social
PhD in Biochemistry 👩🏽🔬
Postdoct at University of Minnesota
MCW alum
Interested in GPCR signaling and trafficking
🇳🇮❤️
Postdoct at University of Minnesota
MCW alum
Interested in GPCR signaling and trafficking
🇳🇮❤️
Reposted by Valeria Robleto, PhD
Huge shout out to my co-first author Maddi Moore, my amazing PI @laurenslosky.bsky.social & our incredible postdoc @valeriarobleto.bsky.social! A big thanks to our collaborators as well as our entire team🎉
October 22, 2025 at 3:44 PM
Huge shout out to my co-first author Maddi Moore, my amazing PI @laurenslosky.bsky.social & our incredible postdoc @valeriarobleto.bsky.social! A big thanks to our collaborators as well as our entire team🎉
Thrilled to share our @nature.com paper is out! 🎉 Honored to be part of the first publication from the @laurenslosky.bsky.social Lab!
We used rational design of allosteric modulators for GPCRs!
Congrats Maddi , @kelseyperson.bsky.social & team!
www.nature.com/articles/s41...
We used rational design of allosteric modulators for GPCRs!
Congrats Maddi , @kelseyperson.bsky.social & team!
www.nature.com/articles/s41...
Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature
Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...
www.nature.com
October 22, 2025 at 3:34 PM
Thrilled to share our @nature.com paper is out! 🎉 Honored to be part of the first publication from the @laurenslosky.bsky.social Lab!
We used rational design of allosteric modulators for GPCRs!
Congrats Maddi , @kelseyperson.bsky.social & team!
www.nature.com/articles/s41...
We used rational design of allosteric modulators for GPCRs!
Congrats Maddi , @kelseyperson.bsky.social & team!
www.nature.com/articles/s41...
Reposted by Valeria Robleto, PhD
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
Design of allosteric modulators that change GPCR G protein subtype selectivity
G protein-coupled receptors (GPCRs), the largest family of drug targets, can signal through 16 subtypes of Gα proteins. Biased compounds that selectively activate therapy-relevant pathways promise to ...
doi.org
November 22, 2024 at 4:09 PM
Can we design allosteric modulators that change a GPCR's preferred G protein? Yes!💥
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
BAMs at the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.
The lab's 1st preprint! Check it out! 🧪💊🧠🟦https://doi.org/10.1101/2024.11.20.624209
🧵👇
New to Bluesky! Here to share my science and connect with other scientists! 🧬
November 22, 2024 at 12:45 AM
New to Bluesky! Here to share my science and connect with other scientists! 🧬