Valentino Ribecco
@valentino-ribecco.bsky.social
PhD in Molecular and Experimental Medicine. Postdoc on glioblastoma tumor microenvironment interactions and resistance mechanisms to treatments at Institut Curie
#ECM #GBM #therapyresistance
#ECM #GBM #therapyresistance
Reposted by Valentino Ribecco
There's not long left for you to submit your abstract for Signalling Circuits in Cancer!
If your research falls into any of these categories, don't miss your opportunity to be included in this new conference topic.
eacr.org/conference/s...
If your research falls into any of these categories, don't miss your opportunity to be included in this new conference topic.
eacr.org/conference/s...
November 17, 2025 at 9:01 AM
There's not long left for you to submit your abstract for Signalling Circuits in Cancer!
If your research falls into any of these categories, don't miss your opportunity to be included in this new conference topic.
eacr.org/conference/s...
If your research falls into any of these categories, don't miss your opportunity to be included in this new conference topic.
eacr.org/conference/s...
Exciting day at BraYn Conference 2025 🇮🇹! I presented our work on how surgery impacts tumors and how its consequences can reduce the effectiveness of standard therapy in glioblastoma. Grateful for the inspiring discussions and amazing Neuro-Oncology session! 🧠💪 #Research #GBM #brayn2025
October 31, 2025 at 1:04 AM
Exciting day at BraYn Conference 2025 🇮🇹! I presented our work on how surgery impacts tumors and how its consequences can reduce the effectiveness of standard therapy in glioblastoma. Grateful for the inspiring discussions and amazing Neuro-Oncology session! 🧠💪 #Research #GBM #brayn2025
Excited to be in Turin for the 8th BraYn Conference – Brainstorming Research Assembly for Young Neuroscientists! 🧠✨
Looking forward to sharing ideas, learning from inspiring colleagues, and exploring new perspectives in neuroscience.
#BraYn2025 #Neuroncology #Research #Torino #GBM #YoungScientists
Looking forward to sharing ideas, learning from inspiring colleagues, and exploring new perspectives in neuroscience.
#BraYn2025 #Neuroncology #Research #Torino #GBM #YoungScientists
October 29, 2025 at 11:22 AM
Excited to be in Turin for the 8th BraYn Conference – Brainstorming Research Assembly for Young Neuroscientists! 🧠✨
Looking forward to sharing ideas, learning from inspiring colleagues, and exploring new perspectives in neuroscience.
#BraYn2025 #Neuroncology #Research #Torino #GBM #YoungScientists
Looking forward to sharing ideas, learning from inspiring colleagues, and exploring new perspectives in neuroscience.
#BraYn2025 #Neuroncology #Research #Torino #GBM #YoungScientists
A great day at EANO2025 where I had the opportunity to present our study: "Postsurgical ischemia fosters tumour cell plasticity in residual GBM"
The need to study the impact of surgery on residual tumor cells is pivotal to understanding how residual tumor cells behave and how recurrence develops.
The need to study the impact of surgery on residual tumor cells is pivotal to understanding how residual tumor cells behave and how recurrence develops.
October 18, 2025 at 1:15 PM
A great day at EANO2025 where I had the opportunity to present our study: "Postsurgical ischemia fosters tumour cell plasticity in residual GBM"
The need to study the impact of surgery on residual tumor cells is pivotal to understanding how residual tumor cells behave and how recurrence develops.
The need to study the impact of surgery on residual tumor cells is pivotal to understanding how residual tumor cells behave and how recurrence develops.
I’m truly honoured to has been selected for the EANO Young Investigator Scholarship by the EANO Scientific Committee for the 20th Meeting of the European Association of Neuro-Oncology in Prague.
A heartfelt thank you to @eanoassociation.bsky.social, @giorgioseano.bsky.social , all my colleagues. 🙏
A heartfelt thank you to @eanoassociation.bsky.social, @giorgioseano.bsky.social , all my colleagues. 🙏
October 16, 2025 at 10:08 AM
I’m truly honoured to has been selected for the EANO Young Investigator Scholarship by the EANO Scientific Committee for the 20th Meeting of the European Association of Neuro-Oncology in Prague.
A heartfelt thank you to @eanoassociation.bsky.social, @giorgioseano.bsky.social , all my colleagues. 🙏
A heartfelt thank you to @eanoassociation.bsky.social, @giorgioseano.bsky.social , all my colleagues. 🙏
Reposted by Valentino Ribecco
It is a true honor to have this opportunity to share our results at such a prestigious meeting again. If you are around, please come to my talk (OS05.7.A), see @valentino-ribecco.bsky.social presentation (OS03.6.A), and stop by Juliette Reveilles (P02.09.B) and Adrien Thomas' (P04.12.A) posters.
October 16, 2025 at 7:45 AM
It is a true honor to have this opportunity to share our results at such a prestigious meeting again. If you are around, please come to my talk (OS05.7.A), see @valentino-ribecco.bsky.social presentation (OS03.6.A), and stop by Juliette Reveilles (P02.09.B) and Adrien Thomas' (P04.12.A) posters.
Reposted by Valentino Ribecco
Join us this November in Bergamo to help shape the future of early-onset cancer research!
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
March 12, 2025 at 2:49 PM
Join us this November in Bergamo to help shape the future of early-onset cancer research!
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients.
In partnership with @themarkfdn.bsky.social 💙
eacr.org/conference/m...
Reposted by Valentino Ribecco
How can patients help shape the future of cancer research?
Join us at our new virtual conference to explore how involving cancer patients in research leads to more meaningful, impactful outcomes.
Learn more and register: eacr.org/conference/p...
Join us at our new virtual conference to explore how involving cancer patients in research leads to more meaningful, impactful outcomes.
Learn more and register: eacr.org/conference/p...
July 30, 2025 at 1:44 PM
How can patients help shape the future of cancer research?
Join us at our new virtual conference to explore how involving cancer patients in research leads to more meaningful, impactful outcomes.
Learn more and register: eacr.org/conference/p...
Join us at our new virtual conference to explore how involving cancer patients in research leads to more meaningful, impactful outcomes.
Learn more and register: eacr.org/conference/p...
Reposted by Valentino Ribecco
You can dive into all the multi-omics data and findings in the full paper.
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Proneural-Mesenchymal hybrid glioblastoma cells are resistant to therapy and dependent on nuclear import
AbstractBackground. Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have ide
doi.org
July 17, 2025 at 9:08 AM
You can dive into all the multi-omics data and findings in the full paper.
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Read more: doi.org/10.1093/neuo....
🧵 (9/9)
Reposted by Valentino Ribecco
🙏 This research wouldn’t have been possible w/o the work of Oceane Anezo, Jeremy Raymond, Alberto Ballestín, Cathy Pichol-Thievend, Juliette Reveilles, Adrien Thomas, @valentino-ribecco.bsky.social, and the collaboration with Celine Vallot, @ggargiul.bsky.social , Vidhya M. Ravi, Kevin Joseph (7/9)
July 17, 2025 at 9:08 AM
🙏 This research wouldn’t have been possible w/o the work of Oceane Anezo, Jeremy Raymond, Alberto Ballestín, Cathy Pichol-Thievend, Juliette Reveilles, Adrien Thomas, @valentino-ribecco.bsky.social, and the collaboration with Celine Vallot, @ggargiul.bsky.social , Vidhya M. Ravi, Kevin Joseph (7/9)
Reposted by Valentino Ribecco
🎉 Huge congrats to Guillaume Bourmeau, leading author and my brilliant PhD student, for spearheading this work on GBM hybrid cells at @institutcurie.bsky.social! Your dedication made this breakthrough possible. (6/9)
#ProudPI,
#ProudPI,
July 17, 2025 at 9:08 AM
🎉 Huge congrats to Guillaume Bourmeau, leading author and my brilliant PhD student, for spearheading this work on GBM hybrid cells at @institutcurie.bsky.social! Your dedication made this breakthrough possible. (6/9)
#ProudPI,
#ProudPI,
Reposted by Valentino Ribecco
🚀 Here's the exciting part: we can target this vulnerability.
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
July 17, 2025 at 9:08 AM
🚀 Here's the exciting part: we can target this vulnerability.
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
We hit them with importazole (import blocker) and selinexor (export inhibitor).
🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)
Reposted by Valentino Ribecco
🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)
July 17, 2025 at 9:08 AM
🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)
Reposted by Valentino Ribecco
🤯 These hybrid cells don’t just look different, they proliferate like they’re on Red Bull and shrug off DNA damage after irradiation. Have they got superhuman repair skills? 🙄 (3/9)
a cartoon drawing of a person holding a pencil with a lightning bolt around it
ALT: a cartoon drawing of a person holding a pencil with a lightning bolt around it
media.tenor.com
July 17, 2025 at 9:08 AM
🤯 These hybrid cells don’t just look different, they proliferate like they’re on Red Bull and shrug off DNA damage after irradiation. Have they got superhuman repair skills? 🙄 (3/9)
Reposted by Valentino Ribecco
🔬 Using dual fluorescent reporters for proneural & mesenchymal states, we tracked live patient-derived glioblastoma lines and uncovered a hybrid population expressing both signatures... let's talk about an identity crisis! (2/9)
a man is peeking through a doorway and smiling .
ALT: a man is peeking through a doorway and smiling .
media.tenor.com
July 17, 2025 at 9:08 AM
🔬 Using dual fluorescent reporters for proneural & mesenchymal states, we tracked live patient-derived glioblastoma lines and uncovered a hybrid population expressing both signatures... let's talk about an identity crisis! (2/9)
Reposted by Valentino Ribecco
🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
July 17, 2025 at 9:08 AM
🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor
🚀 𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗴𝗿𝗼𝘂𝗻𝗱 𝗶𝗻 𝗴𝗹𝗶𝗼𝗯𝗹𝗮𝘀𝘁𝗼𝗺𝗮 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵! 🧠🔬
It’s a great pleasure to announce that my PhD work it’s finally out! After five years of dedicated effort, shared with two talented researchers Matteo Tamborini and Elisabetta Stanzani, this journey has been both challenging and rewarding. 1/5
It’s a great pleasure to announce that my PhD work it’s finally out! After five years of dedicated effort, shared with two talented researchers Matteo Tamborini and Elisabetta Stanzani, this journey has been both challenging and rewarding. 1/5
Extracellular Vesicles Released by Glioblastoma Cancer Cells Drive Tumor Invasiveness via Connexin-43 Gap Junctions
AbstractBackground. Although invasiveness is one of the major determinants of the poor glioblastoma (GBM) outcome, the mechanisms of GBM invasion are only
academic.oup.com
April 2, 2025 at 10:34 PM
🚀 𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗴𝗿𝗼𝘂𝗻𝗱 𝗶𝗻 𝗴𝗹𝗶𝗼𝗯𝗹𝗮𝘀𝘁𝗼𝗺𝗮 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵! 🧠🔬
It’s a great pleasure to announce that my PhD work it’s finally out! After five years of dedicated effort, shared with two talented researchers Matteo Tamborini and Elisabetta Stanzani, this journey has been both challenging and rewarding. 1/5
It’s a great pleasure to announce that my PhD work it’s finally out! After five years of dedicated effort, shared with two talented researchers Matteo Tamborini and Elisabetta Stanzani, this journey has been both challenging and rewarding. 1/5
Reposted by Valentino Ribecco
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research
https://go.nature.com/4gc0Bc5
https://go.nature.com/4gc0Bc5
‘Never seen anything like this’: Trump’s team halts NIH meetings and travel
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research.
go.nature.com
January 24, 2025 at 1:08 PM
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research
https://go.nature.com/4gc0Bc5
https://go.nature.com/4gc0Bc5