Nature Metabolism, Published online: 13 May 2025; doi:10.1038/s42255-025-01296-9In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

Hansen et al. show that the hepatic stellate cell-expressed plasmalemma vesicle-associated protein is required for the normal switch from carbohydrate to lipid utilization during fasting. This reveals...