TRAIL4Life
@trail4l.bsky.social
Developing novel diagnostic and therapeutic tools targeting the TRIL/DR death-signalling pathway. Co-funded by the European Union ('CHIRON', #101130240).
As part of the Teaching & Training Presentation Series in cooperation with Izmir Biomedicine and Genome Center and RareBoost, we invite you to join us for the lecture "Introduction to Immunology" by Dr. Gerhard Wingender.
November 12, 2025 at 3:45 PM
As part of the Teaching & Training Presentation Series in cooperation with Izmir Biomedicine and Genome Center and RareBoost, we invite you to join us for the lecture "Introduction to Immunology" by Dr. Gerhard Wingender.
✨It was great to see #CHIRONProject partner Dr. Philippe Krebs presenting at the Biomedical Research Foundation, Academy of Athens!
The talk, titled "𝗞𝗲𝗲𝗽 𝗖𝗮𝗹𝗺: 𝗧𝗵𝗲 𝗠𝘂𝗰𝗼𝘀𝗮𝗹 𝗕𝗮𝗿𝗿𝗶𝗲𝗿 𝗮𝘁 𝘁𝗵𝗲 𝗜𝗻𝘁𝗲𝗿𝗳𝗮𝗰𝗲 𝗼𝗳 𝗣𝗲𝗮𝗰𝗲 𝗮𝗻𝗱 𝗪𝗮𝗿", explored how the mucosal barrier balances homeostasis and inflammation.
The talk, titled "𝗞𝗲𝗲𝗽 𝗖𝗮𝗹𝗺: 𝗧𝗵𝗲 𝗠𝘂𝗰𝗼𝘀𝗮𝗹 𝗕𝗮𝗿𝗿𝗶𝗲𝗿 𝗮𝘁 𝘁𝗵𝗲 𝗜𝗻𝘁𝗲𝗿𝗳𝗮𝗰𝗲 𝗼𝗳 𝗣𝗲𝗮𝗰𝗲 𝗮𝗻𝗱 𝗪𝗮𝗿", explored how the mucosal barrier balances homeostasis and inflammation.
November 3, 2025 at 6:35 AM
✨It was great to see #CHIRONProject partner Dr. Philippe Krebs presenting at the Biomedical Research Foundation, Academy of Athens!
The talk, titled "𝗞𝗲𝗲𝗽 𝗖𝗮𝗹𝗺: 𝗧𝗵𝗲 𝗠𝘂𝗰𝗼𝘀𝗮𝗹 𝗕𝗮𝗿𝗿𝗶𝗲𝗿 𝗮𝘁 𝘁𝗵𝗲 𝗜𝗻𝘁𝗲𝗿𝗳𝗮𝗰𝗲 𝗼𝗳 𝗣𝗲𝗮𝗰𝗲 𝗮𝗻𝗱 𝗪𝗮𝗿", explored how the mucosal barrier balances homeostasis and inflammation.
The talk, titled "𝗞𝗲𝗲𝗽 𝗖𝗮𝗹𝗺: 𝗧𝗵𝗲 𝗠𝘂𝗰𝗼𝘀𝗮𝗹 𝗕𝗮𝗿𝗿𝗶𝗲𝗿 𝗮𝘁 𝘁𝗵𝗲 𝗜𝗻𝘁𝗲𝗿𝗳𝗮𝗰𝗲 𝗼𝗳 𝗣𝗲𝗮𝗰𝗲 𝗮𝗻𝗱 𝗪𝗮𝗿", explored how the mucosal barrier balances homeostasis and inflammation.
As #CHIRONProject, we successfully completed an inspiring session with Prof. Fahri Saatçıoğlu from the University of Oslo, as part of the Teaching & Training Series in cooperation with IBG & RareBoost.
October 24, 2025 at 10:06 AM
As #CHIRONProject, we successfully completed an inspiring session with Prof. Fahri Saatçıoğlu from the University of Oslo, as part of the Teaching & Training Series in cooperation with IBG & RareBoost.
✨We’re delighted to welcome Maria Despoina Liassa (from e-NIOS) to the Wingender Lab at IBG as part of her secondment within the #CHIRONProject!
It’s a pleasure to have her join the team and share her expertise and enthusiasm.
It’s a pleasure to have her join the team and share her expertise and enthusiasm.
October 23, 2025 at 8:35 AM
✨We’re delighted to welcome Maria Despoina Liassa (from e-NIOS) to the Wingender Lab at IBG as part of her secondment within the #CHIRONProject!
It’s a pleasure to have her join the team and share her expertise and enthusiasm.
It’s a pleasure to have her join the team and share her expertise and enthusiasm.
During his visit to our partner Dr. Micheau (INSERM, Dijon, France), Dr. Wingender (IBG, Izmir, Turkey) had the opportunity to introduce our #CHIRONProject and IBG's contribution to it at CTM's annual scientific meeting (3.10.25) of the Center for Translational and Molecular Medicine (CTM, Dijon).
October 20, 2025 at 8:47 AM
During his visit to our partner Dr. Micheau (INSERM, Dijon, France), Dr. Wingender (IBG, Izmir, Turkey) had the opportunity to introduce our #CHIRONProject and IBG's contribution to it at CTM's annual scientific meeting (3.10.25) of the Center for Translational and Molecular Medicine (CTM, Dijon).
As part of the Teaching & Training Series in cooperation with IBG & RareBoost, join Prof. Fahri Saatçıoğlu (University of Oslo) for The Science of Breath – Practical Knowledge for Health and Wellness, exploring breathing techniques to boost health and wellbeing.
October 15, 2025 at 10:03 AM
As part of the Teaching & Training Series in cooperation with IBG & RareBoost, join Prof. Fahri Saatçıoğlu (University of Oslo) for The Science of Breath – Practical Knowledge for Health and Wellness, exploring breathing techniques to boost health and wellbeing.
A glimpse from our project partners in Athens💫
Discussing the circuitry of immune cell subtypes in cancer on a rainy Athenian day. Fantastic to see this collaboration in motion!
#CHIRONProject #ResearchCollaboration #Science #ScientificPartnership
Discussing the circuitry of immune cell subtypes in cancer on a rainy Athenian day. Fantastic to see this collaboration in motion!
#CHIRONProject #ResearchCollaboration #Science #ScientificPartnership
October 14, 2025 at 8:19 AM
A glimpse from our project partners in Athens💫
Discussing the circuitry of immune cell subtypes in cancer on a rainy Athenian day. Fantastic to see this collaboration in motion!
#CHIRONProject #ResearchCollaboration #Science #ScientificPartnership
Discussing the circuitry of immune cell subtypes in cancer on a rainy Athenian day. Fantastic to see this collaboration in motion!
#CHIRONProject #ResearchCollaboration #Science #ScientificPartnership
The experience of our secondee János Máté Orosz (BME):
"Over the course of my one-month secondment at the University of Galway, Ireland, I had the opportunity to gain valuable knowledge in cell biology (cell culture and in vitro cytotoxicity measurements) under the supervision of Eva Szegezdi.
"Over the course of my one-month secondment at the University of Galway, Ireland, I had the opportunity to gain valuable knowledge in cell biology (cell culture and in vitro cytotoxicity measurements) under the supervision of Eva Szegezdi.
October 7, 2025 at 7:41 AM
The experience of our secondee János Máté Orosz (BME):
"Over the course of my one-month secondment at the University of Galway, Ireland, I had the opportunity to gain valuable knowledge in cell biology (cell culture and in vitro cytotoxicity measurements) under the supervision of Eva Szegezdi.
"Over the course of my one-month secondment at the University of Galway, Ireland, I had the opportunity to gain valuable knowledge in cell biology (cell culture and in vitro cytotoxicity measurements) under the supervision of Eva Szegezdi.
After a long day of insightful discussions on bioinformatic approaches to deciphering the role of TRAIL/DRs in the tumour microenvironment with #CHIRONProject partner Dr. Eleftherios Pilalis (eNIOS, Greece), the #IBG team rounded off the evening with a delightful dinner by the Izmir bay.
October 1, 2025 at 6:00 AM
After a long day of insightful discussions on bioinformatic approaches to deciphering the role of TRAIL/DRs in the tumour microenvironment with #CHIRONProject partner Dr. Eleftherios Pilalis (eNIOS, Greece), the #IBG team rounded off the evening with a delightful dinner by the Izmir bay.
Our partner, Dr. Philippe Krebs from the University of Bern (Switzerland), arrived at e-NIOS (Athens, Greece) to advance #CHIRONProject's collaboration with our partners, Dr. Aristotelis Chatziioannou and Dr. Eleftherios Pilalis, and the rest of the team.
We are excited about the progress ahead🌟
We are excited about the progress ahead🌟
September 24, 2025 at 8:46 AM
Our partner, Dr. Philippe Krebs from the University of Bern (Switzerland), arrived at e-NIOS (Athens, Greece) to advance #CHIRONProject's collaboration with our partners, Dr. Aristotelis Chatziioannou and Dr. Eleftherios Pilalis, and the rest of the team.
We are excited about the progress ahead🌟
We are excited about the progress ahead🌟
✨We are glad to see #CHIRONProject secondees Javid and Wanshan from #Galway starting their two-month secondment at #INSERM Dijon, where they will work under the supervision of Olivier Micheau.
September 3, 2025 at 11:55 AM
✨We are glad to see #CHIRONProject secondees Javid and Wanshan from #Galway starting their two-month secondment at #INSERM Dijon, where they will work under the supervision of Olivier Micheau.
🚨New study alert
Rapidly dividing tumours need lots of energy; therefore, restricting access to sugar, e.g. via the diet, can curb the growth of primary tumours. Surprisingly, however, a new study noted that this can increase the frequency of lung metastases.
www.cell.com/cell/abstrac...
Rapidly dividing tumours need lots of energy; therefore, restricting access to sugar, e.g. via the diet, can curb the growth of primary tumours. Surprisingly, however, a new study noted that this can increase the frequency of lung metastases.
www.cell.com/cell/abstrac...
Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL
While targeting glucose metabolism shows potential in cancer therapy, its clinical
implications remain unclear. This study finds that low-carbohydrate diets or impaired
glucose metabolism in cancer ce...
www.cell.com
July 31, 2025 at 8:18 AM
🚨New study alert
Rapidly dividing tumours need lots of energy; therefore, restricting access to sugar, e.g. via the diet, can curb the growth of primary tumours. Surprisingly, however, a new study noted that this can increase the frequency of lung metastases.
www.cell.com/cell/abstrac...
Rapidly dividing tumours need lots of energy; therefore, restricting access to sugar, e.g. via the diet, can curb the growth of primary tumours. Surprisingly, however, a new study noted that this can increase the frequency of lung metastases.
www.cell.com/cell/abstrac...
Dr. Tutku Yaraş's presentation “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures” is now available on our YouTube channel.
www.youtube.com/watch?v=3ZTj...
#seminar #research #science #bioinformatics
www.youtube.com/watch?v=3ZTj...
#seminar #research #science #bioinformatics
Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures
YouTube video by TRAIL4Life
www.youtube.com
July 30, 2025 at 7:18 AM
Dr. Tutku Yaraş's presentation “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures” is now available on our YouTube channel.
www.youtube.com/watch?v=3ZTj...
#seminar #research #science #bioinformatics
www.youtube.com/watch?v=3ZTj...
#seminar #research #science #bioinformatics
Many colorectal cancer cells express high levels of the death receptor DR5, which the researchers here leveraged as a therapeutic target. They tested a drug called Oba01, which is a conjugate of a DR5-specific antibody with a potent toxin.
pubmed.ncbi.nlm.nih.gov/40449480/
pubmed.ncbi.nlm.nih.gov/40449480/
Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer - PubMed
Targeted therapies for advanced microsatellite stable (MSS) subtype colorectal cancer (MSS-CRC) remain a clinical challenge. Here, we show that death receptor 5 (DR5) is elevated in both MSS and micro...
pubmed.ncbi.nlm.nih.gov
July 22, 2025 at 7:20 AM
Many colorectal cancer cells express high levels of the death receptor DR5, which the researchers here leveraged as a therapeutic target. They tested a drug called Oba01, which is a conjugate of a DR5-specific antibody with a potent toxin.
pubmed.ncbi.nlm.nih.gov/40449480/
pubmed.ncbi.nlm.nih.gov/40449480/
#CHIRONProject partner Dr. Eva Szegezdi (University of Galway) gave a talk titled “TRAIL engineered NK cells for the treatment of lymphoma” at the Biseach Meeting-the annual collaborative meeting between the Harper Cancer Research Institute, the University of Notre Dame and the University of Galway.
July 16, 2025 at 8:19 AM
#CHIRONProject partner Dr. Eva Szegezdi (University of Galway) gave a talk titled “TRAIL engineered NK cells for the treatment of lymphoma” at the Biseach Meeting-the annual collaborative meeting between the Harper Cancer Research Institute, the University of Notre Dame and the University of Galway.
We completed our seminar “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures”.
We thank Dr. Tutku Yaraş for her insightful presentation and appreciate all participants for joining us.✨
We thank Dr. Tutku Yaraş for her insightful presentation and appreciate all participants for joining us.✨
July 10, 2025 at 10:22 AM
We completed our seminar “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures”.
We thank Dr. Tutku Yaraş for her insightful presentation and appreciate all participants for joining us.✨
We thank Dr. Tutku Yaraş for her insightful presentation and appreciate all participants for joining us.✨
🔔Reminder
Join us tomorrow for our session:
“Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures”
Register for online participation: lu.ma/7qac6h24
Don’t miss this opportunity to sharpen your data visualization skills!
#Bioinformatics #DataVisualization
Join us tomorrow for our session:
“Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures”
Register for online participation: lu.ma/7qac6h24
Don’t miss this opportunity to sharpen your data visualization skills!
#Bioinformatics #DataVisualization
July 9, 2025 at 6:51 AM
🔔Reminder
Join us tomorrow for our session:
“Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures”
Register for online participation: lu.ma/7qac6h24
Don’t miss this opportunity to sharpen your data visualization skills!
#Bioinformatics #DataVisualization
Join us tomorrow for our session:
“Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures”
Register for online participation: lu.ma/7qac6h24
Don’t miss this opportunity to sharpen your data visualization skills!
#Bioinformatics #DataVisualization
As part of the Teaching & Training Presentation Series in cooperation with Izmir Biomedicine and Genome Center and
RareBoost, we will hold a session titled “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures” presented by Dr. Tutku Yaraş.
RareBoost, we will hold a session titled “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures” presented by Dr. Tutku Yaraş.
June 30, 2025 at 7:09 AM
As part of the Teaching & Training Presentation Series in cooperation with Izmir Biomedicine and Genome Center and
RareBoost, we will hold a session titled “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures” presented by Dr. Tutku Yaraş.
RareBoost, we will hold a session titled “Decoding Bioinformatics Visualizations: A practical guide to understand common scientific figures” presented by Dr. Tutku Yaraş.
Dr. Wingender, immunologist, Group Leader at the Izmir Biomedicine and Genome Center, and the coordinator of #CHIRONProject, presented a great seminar for PhD students with the title of 'The immune system and the role of iNKT cells' at the Faculty of Chemical Technology and Biotechnology at the BME✨
June 16, 2025 at 7:04 AM
Dr. Wingender, immunologist, Group Leader at the Izmir Biomedicine and Genome Center, and the coordinator of #CHIRONProject, presented a great seminar for PhD students with the title of 'The immune system and the role of iNKT cells' at the Faculty of Chemical Technology and Biotechnology at the BME✨
✨New study published by #CHIRONProject partner Olivier Micheau, Université Bourgogne Europe, CTM Dijon INSERM, DesCarTes team, ICB, ICMUB – Institute of Molecular Chemistry of Université Bourgogne Europe, and Université de Franche-Comté👏
Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation
Pro-apoptotic receptor activators (PARAs), including second-generation agonist antibodies and ligands targeting the TNF receptor superfamily such as T…
www.sciencedirect.com
June 10, 2025 at 9:03 AM
✨New study published by #CHIRONProject partner Olivier Micheau, Université Bourgogne Europe, CTM Dijon INSERM, DesCarTes team, ICB, ICMUB – Institute of Molecular Chemistry of Université Bourgogne Europe, and Université de Franche-Comté👏
The experience of our secondee Bettina Rávai (BME):
"During my secondment at INSERM in Dijon, I had the opportunity to gain my first experiences in cell and molecular biology through different labworks with human cancer cell cultures and cytotoxicity assays.
"During my secondment at INSERM in Dijon, I had the opportunity to gain my first experiences in cell and molecular biology through different labworks with human cancer cell cultures and cytotoxicity assays.
June 3, 2025 at 11:47 AM
The experience of our secondee Bettina Rávai (BME):
"During my secondment at INSERM in Dijon, I had the opportunity to gain my first experiences in cell and molecular biology through different labworks with human cancer cell cultures and cytotoxicity assays.
"During my secondment at INSERM in Dijon, I had the opportunity to gain my first experiences in cell and molecular biology through different labworks with human cancer cell cultures and cytotoxicity assays.
For #CHIRONProject's second annual meeting, team members gathered in beautiful Budapest (Hungary). In this productive and engaging week, we had the opportunity to discuss the project's results, coordinate the next steps, and have a scientific and personal exchange.
May 28, 2025 at 8:32 AM
For #CHIRONProject's second annual meeting, team members gathered in beautiful Budapest (Hungary). In this productive and engaging week, we had the opportunity to discuss the project's results, coordinate the next steps, and have a scientific and personal exchange.
Assist. Prof. Ezgi Karaca's presentation 'The AI Revolution in Structural Biology: 2024 Chemistry Nobel Prize' is now available on our YouTube channel.
www.youtube.com/watch?v=ZbcJ...
#research #science #seminar
www.youtube.com/watch?v=ZbcJ...
#research #science #seminar
The AI Revolution in Structural Biology: 2024 Chemistry Nobel Prize
YouTube video by TRAIL4Life
www.youtube.com
May 13, 2025 at 2:34 PM
Assist. Prof. Ezgi Karaca's presentation 'The AI Revolution in Structural Biology: 2024 Chemistry Nobel Prize' is now available on our YouTube channel.
www.youtube.com/watch?v=ZbcJ...
#research #science #seminar
www.youtube.com/watch?v=ZbcJ...
#research #science #seminar
#CHIRONProject partner Dr. Wingender (IBG) introduced the immune system and its role in diseases like cancer during the ACUGEN student congress in Istanbul, Acıbadem University (19-20.4.2025)✨
#Acugen #AcıbademUniversity #congress #lifesciences #immunology
#Acugen #AcıbademUniversity #congress #lifesciences #immunology
May 1, 2025 at 10:14 AM
#CHIRONProject partner Dr. Wingender (IBG) introduced the immune system and its role in diseases like cancer during the ACUGEN student congress in Istanbul, Acıbadem University (19-20.4.2025)✨
#Acugen #AcıbademUniversity #congress #lifesciences #immunology
#Acugen #AcıbademUniversity #congress #lifesciences #immunology