Timothy P. Jenkins
@tpjenkins.bsky.social
I am an Associate Professor at DTU and leading the Digital Biotechnology Lab. I am passionate about harnessing the power of modern technology such as AI Protein Design to innovate the biotechnological landscape and develop real world solutions.
We believe this approach can accelerate the development of safer, more effective immunotherapies for patients.
And a special thank you to the talented @mfernandezquintero.bsky.social & Johannes Loeffler for the stunning graphic! 🎨
#CancerResearch #Immunotherapy #AI
And a special thank you to the talented @mfernandezquintero.bsky.social & Johannes Loeffler for the stunning graphic! 🎨
#CancerResearch #Immunotherapy #AI
July 24, 2025 at 6:27 PM
We believe this approach can accelerate the development of safer, more effective immunotherapies for patients.
And a special thank you to the talented @mfernandezquintero.bsky.social & Johannes Loeffler for the stunning graphic! 🎨
#CancerResearch #Immunotherapy #AI
And a special thank you to the talented @mfernandezquintero.bsky.social & Johannes Loeffler for the stunning graphic! 🎨
#CancerResearch #Immunotherapy #AI
This was a monumental team effort bringing together immunology, computational biology, and structural biology.
A huge congratulations to the incredible teams at DTU HealthTech, DTU Bioengineering, & @scripps.edu and to all my brilliant co-authors, especially @Kristoffer Haurum Johansen.
A huge congratulations to the incredible teams at DTU HealthTech, DTU Bioengineering, & @scripps.edu and to all my brilliant co-authors, especially @Kristoffer Haurum Johansen.
July 24, 2025 at 6:27 PM
This was a monumental team effort bringing together immunology, computational biology, and structural biology.
A huge congratulations to the incredible teams at DTU HealthTech, DTU Bioengineering, & @scripps.edu and to all my brilliant co-authors, especially @Kristoffer Haurum Johansen.
A huge congratulations to the incredible teams at DTU HealthTech, DTU Bioengineering, & @scripps.edu and to all my brilliant co-authors, especially @Kristoffer Haurum Johansen.
Our platform's key achievements include:
⚡️ Speed: A rapid 4-6 week pipeline from computer design to validated lab result.
🎯 Precision: An AI-driven process to screen for specificity & reduce off-target risks.
🤝 Personalization: It works even for a patient's unique tumor mutation.
⚡️ Speed: A rapid 4-6 week pipeline from computer design to validated lab result.
🎯 Precision: An AI-driven process to screen for specificity & reduce off-target risks.
🤝 Personalization: It works even for a patient's unique tumor mutation.
July 24, 2025 at 6:27 PM
Our platform's key achievements include:
⚡️ Speed: A rapid 4-6 week pipeline from computer design to validated lab result.
🎯 Precision: An AI-driven process to screen for specificity & reduce off-target risks.
🤝 Personalization: It works even for a patient's unique tumor mutation.
⚡️ Speed: A rapid 4-6 week pipeline from computer design to validated lab result.
🎯 Precision: An AI-driven process to screen for specificity & reduce off-target risks.
🤝 Personalization: It works even for a patient's unique tumor mutation.
In this work, we designed completely novel proteins, or ‘minibinders,’ from scratch. 🤖
These act as a high-precision guidance system, leading a patient's own T-cells (black) to recognize and destroy cancer cells (red) with remarkable accuracy.
#ProteinDesign #GenerativeAI
These act as a high-precision guidance system, leading a patient's own T-cells (black) to recognize and destroy cancer cells (red) with remarkable accuracy.
#ProteinDesign #GenerativeAI
July 24, 2025 at 6:27 PM
In this work, we designed completely novel proteins, or ‘minibinders,’ from scratch. 🤖
These act as a high-precision guidance system, leading a patient's own T-cells (black) to recognize and destroy cancer cells (red) with remarkable accuracy.
#ProteinDesign #GenerativeAI
These act as a high-precision guidance system, leading a patient's own T-cells (black) to recognize and destroy cancer cells (red) with remarkable accuracy.
#ProteinDesign #GenerativeAI
Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org!
We used generative AI to build a 'GPS' for immune cells to hunt cancer.
Read it here: doi.org/10.1126/scie...
We used generative AI to build a 'GPS' for immune cells to hunt cancer.
Read it here: doi.org/10.1126/scie...
July 24, 2025 at 6:27 PM
Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org!
We used generative AI to build a 'GPS' for immune cells to hunt cancer.
Read it here: doi.org/10.1126/scie...
We used generative AI to build a 'GPS' for immune cells to hunt cancer.
Read it here: doi.org/10.1126/scie...
💡 Curious about:
– How generative AI is transforming protein research?
– Why mass spec is such a rich (but messy) playground for AI?
– What it takes to go from spectrum to sequence to structure?
Give it a listen 🎧
– How generative AI is transforming protein research?
– Why mass spec is such a rich (but messy) playground for AI?
– What it takes to go from spectrum to sequence to structure?
Give it a listen 🎧
May 30, 2025 at 8:35 AM
💡 Curious about:
– How generative AI is transforming protein research?
– Why mass spec is such a rich (but messy) playground for AI?
– What it takes to go from spectrum to sequence to structure?
Give it a listen 🎧
– How generative AI is transforming protein research?
– Why mass spec is such a rich (but messy) playground for AI?
– What it takes to go from spectrum to sequence to structure?
Give it a listen 🎧
🚨 We’re hiring a PhD student! 🚨
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
May 14, 2025 at 9:33 PM
🚨 We’re hiring a PhD student! 🚨
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
🚨 Big news! We’ve received a NovoNordisk Foundation Tandem Grant for #MIGRAINE — designing #AI-powered #GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud and Hakan Ashina, as well as Esperanza Rivera de Torre!
🧠 + 💊 + 🧬 = new hope.
🧠 + 💊 + 🧬 = new hope.
May 12, 2025 at 11:39 AM
🚨 Big news! We’ve received a NovoNordisk Foundation Tandem Grant for #MIGRAINE — designing #AI-powered #GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud and Hakan Ashina, as well as Esperanza Rivera de Torre!
🧠 + 💊 + 🧬 = new hope.
🧠 + 💊 + 🧬 = new hope.
We’re already supporting:
– Proteins that are hard to purify
– Assays that demand specificity
– Targets that need quantitative detection
Please reach out if you want to hear more.
#StartupLaunch #Founder #AffinityAI
– Proteins that are hard to purify
– Assays that demand specificity
– Targets that need quantitative detection
Please reach out if you want to hear more.
#StartupLaunch #Founder #AffinityAI
May 8, 2025 at 12:44 PM
We’re already supporting:
– Proteins that are hard to purify
– Assays that demand specificity
– Targets that need quantitative detection
Please reach out if you want to hear more.
#StartupLaunch #Founder #AffinityAI
– Proteins that are hard to purify
– Assays that demand specificity
– Targets that need quantitative detection
Please reach out if you want to hear more.
#StartupLaunch #Founder #AffinityAI
What we offer:
– Designerbodies™ with pM–nM affinity
– ARCANE™ designs for affinity, stability, and expression
– RAVEN™ screens candidates at scale
Built for diagnostics, therapeutics, and biotech pipelines.
#AIinBiotech #SyntheticBiology
– Designerbodies™ with pM–nM affinity
– ARCANE™ designs for affinity, stability, and expression
– RAVEN™ screens candidates at scale
Built for diagnostics, therapeutics, and biotech pipelines.
#AIinBiotech #SyntheticBiology
May 8, 2025 at 12:44 PM
What we offer:
– Designerbodies™ with pM–nM affinity
– ARCANE™ designs for affinity, stability, and expression
– RAVEN™ screens candidates at scale
Built for diagnostics, therapeutics, and biotech pipelines.
#AIinBiotech #SyntheticBiology
– Designerbodies™ with pM–nM affinity
– ARCANE™ designs for affinity, stability, and expression
– RAVEN™ screens candidates at scale
Built for diagnostics, therapeutics, and biotech pipelines.
#AIinBiotech #SyntheticBiology
🚀 Big news: AffinityAI is live
We’ve built a platform for custom protein binders, AI-designed, in vitro validated, and entirely animal-free.
I'm proud to lead this as CEO.
🔗 affinityai.org
#AffinityAI #Biotech #ProteinEngineering
We’ve built a platform for custom protein binders, AI-designed, in vitro validated, and entirely animal-free.
I'm proud to lead this as CEO.
🔗 affinityai.org
#AffinityAI #Biotech #ProteinEngineering
May 8, 2025 at 12:44 PM
🚀 Big news: AffinityAI is live
We’ve built a platform for custom protein binders, AI-designed, in vitro validated, and entirely animal-free.
I'm proud to lead this as CEO.
🔗 affinityai.org
#AffinityAI #Biotech #ProteinEngineering
We’ve built a platform for custom protein binders, AI-designed, in vitro validated, and entirely animal-free.
I'm proud to lead this as CEO.
🔗 affinityai.org
#AffinityAI #Biotech #ProteinEngineering
Thanks to our funders:
💙 Novo Nordisk Foundation
💡 ERC
🔬 Wellcome Trust
🧪 PRO-MS
🏛️ Villum Fonden
#AI #Proteomics #DeNovoSequencing #MassSpec #InstaNovo #NatureMachineIntelligence
💙 Novo Nordisk Foundation
💡 ERC
🔬 Wellcome Trust
🧪 PRO-MS
🏛️ Villum Fonden
#AI #Proteomics #DeNovoSequencing #MassSpec #InstaNovo #NatureMachineIntelligence
April 1, 2025 at 7:30 AM
Thanks to our funders:
💙 Novo Nordisk Foundation
💡 ERC
🔬 Wellcome Trust
🧪 PRO-MS
🏛️ Villum Fonden
#AI #Proteomics #DeNovoSequencing #MassSpec #InstaNovo #NatureMachineIntelligence
💙 Novo Nordisk Foundation
💡 ERC
🔬 Wellcome Trust
🧪 PRO-MS
🏛️ Villum Fonden
#AI #Proteomics #DeNovoSequencing #MassSpec #InstaNovo #NatureMachineIntelligence
These models boost peptide discovery by 50%+ 📈 over prior tools.
Applications include:
🧬 Personalised cancer immunotherapy
⚗️ Direct protein sequencing
🦠 Pathogen discovery in complex samples
Applications include:
🧬 Personalised cancer immunotherapy
⚗️ Direct protein sequencing
🦠 Pathogen discovery in complex samples
April 1, 2025 at 7:30 AM
These models boost peptide discovery by 50%+ 📈 over prior tools.
Applications include:
🧬 Personalised cancer immunotherapy
⚗️ Direct protein sequencing
🦠 Pathogen discovery in complex samples
Applications include:
🧬 Personalised cancer immunotherapy
⚗️ Direct protein sequencing
🦠 Pathogen discovery in complex samples
We developed InstaNovo & InstaNovo+, combining transformers 🧠 with diffusion models 🔁 to solve one of proteomics' hardest problems:
🚫 No genome? No problem.
✅ De novo sequencing from raw spectra — fast & accurate.
🚫 No genome? No problem.
✅ De novo sequencing from raw spectra — fast & accurate.
April 1, 2025 at 7:30 AM
We developed InstaNovo & InstaNovo+, combining transformers 🧠 with diffusion models 🔁 to solve one of proteomics' hardest problems:
🚫 No genome? No problem.
✅ De novo sequencing from raw spectra — fast & accurate.
🚫 No genome? No problem.
✅ De novo sequencing from raw spectra — fast & accurate.
🚀 Tackling one of life science’s biggest challenges: AI-driven biologics design!
Excited to lead #DTU’s collaboration with #NovoNordisk to build a closed-loop #AI platform for binder design & optimization.
Even better? We’re hiring! 📢 6 open positions! 🎉
(1/5)
Excited to lead #DTU’s collaboration with #NovoNordisk to build a closed-loop #AI platform for binder design & optimization.
Even better? We’re hiring! 📢 6 open positions! 🎉
(1/5)
February 18, 2025 at 12:05 PM
🚀 Tackling one of life science’s biggest challenges: AI-driven biologics design!
Excited to lead #DTU’s collaboration with #NovoNordisk to build a closed-loop #AI platform for binder design & optimization.
Even better? We’re hiring! 📢 6 open positions! 🎉
(1/5)
Excited to lead #DTU’s collaboration with #NovoNordisk to build a closed-loop #AI platform for binder design & optimization.
Even better? We’re hiring! 📢 6 open positions! 🎉
(1/5)
🔬 Using #AI-powered protein design, our antitoxins showed 80–100% survival in mice.
These AI proteins are
✅ #Accessible: Microbe-manufactured, bypassing animal immunisation
✅ #Precise: Target only the most harmful venom components
✅ Fast: Dramatically reduced discovery times
These AI proteins are
✅ #Accessible: Microbe-manufactured, bypassing animal immunisation
✅ #Precise: Target only the most harmful venom components
✅ Fast: Dramatically reduced discovery times
January 15, 2025 at 8:16 PM
🔬 Using #AI-powered protein design, our antitoxins showed 80–100% survival in mice.
These AI proteins are
✅ #Accessible: Microbe-manufactured, bypassing animal immunisation
✅ #Precise: Target only the most harmful venom components
✅ Fast: Dramatically reduced discovery times
These AI proteins are
✅ #Accessible: Microbe-manufactured, bypassing animal immunisation
✅ #Precise: Target only the most harmful venom components
✅ Fast: Dramatically reduced discovery times
🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍
I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.
I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.
January 15, 2025 at 8:16 PM
🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍
I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.
I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.
🎉Looking for an exciting opportunity in proteomics and data science?🎉
Join DTU Bioengineering as a #Data #Science Specialist in #Proteomics! Based at our state-of-the-art DTU Proteomics Core.
You'll also collaborate with me and the DTU Bioengineering Data Science Hub.
lnkd.in/d2zHaMys
Join DTU Bioengineering as a #Data #Science Specialist in #Proteomics! Based at our state-of-the-art DTU Proteomics Core.
You'll also collaborate with me and the DTU Bioengineering Data Science Hub.
lnkd.in/d2zHaMys
January 13, 2025 at 7:43 PM
🎉Looking for an exciting opportunity in proteomics and data science?🎉
Join DTU Bioengineering as a #Data #Science Specialist in #Proteomics! Based at our state-of-the-art DTU Proteomics Core.
You'll also collaborate with me and the DTU Bioengineering Data Science Hub.
lnkd.in/d2zHaMys
Join DTU Bioengineering as a #Data #Science Specialist in #Proteomics! Based at our state-of-the-art DTU Proteomics Core.
You'll also collaborate with me and the DTU Bioengineering Data Science Hub.
lnkd.in/d2zHaMys
🌟 Thrilled to announce that our project, Deep Immune Receptor Modeling (#DIRM), has been awarded funding under the (@novo-nordisk.bsky.social) Nordisk Foundation Data Science Collaborative Research Programme! 🎉
December 19, 2024 at 4:04 PM
🌟 Thrilled to announce that our project, Deep Immune Receptor Modeling (#DIRM), has been awarded funding under the (@novo-nordisk.bsky.social) Nordisk Foundation Data Science Collaborative Research Programme! 🎉
Last week, David Baker, alongside John Jumper and Demis Hassabis, received the #Nobel Prize in #Chemistry🏆. It was incredibly special to see our group's and collaborators' work highlighted in the Nobel speech, along with the vital issue of #snakebite #envenoming🎉.
December 16, 2024 at 9:34 PM
Last week, David Baker, alongside John Jumper and Demis Hassabis, received the #Nobel Prize in #Chemistry🏆. It was incredibly special to see our group's and collaborators' work highlighted in the Nobel speech, along with the vital issue of #snakebite #envenoming🎉.