Toby Baril
@tobybarilbio.bsky.social
Postdoc Fellow @ Uni Neuchâtel 🇨🇭 | Transposable Elements + SV, Evolution across scales | #openscience | #FirstGen | 🇬🇧🇫🇷 | Ski | Bike | Climb | Join TEsky: https://bsky.app/profile/did:plc:mw4y54k2y45j5dqxrbelwvmu/feed/aaad7mmgzkfuu
tobybaril.github.io
tobybaril.github.io
Pinned
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
www.nature.com
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen - Nature Communications
In this study, the authors analysed a large genomic dataset to trace how jumping genes shaped the global spread of a major wheat pathogen and reveal bursts of activity over decades that drove adaptati...
www.nature.com
November 12, 2025 at 1:17 PM
TEs aren’t just genomic parasites, they’re also engines of genomic novelty.
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Our new study with ~2,000 Z. tritici genomes shows repeated TE mobilization waves during global expansion.
With @danielcroll.bsky.social & @guidopuccetti.bsky.social
🧬 www.nature.com/articles/s41...
#TEworldwide
Reposted by Toby Baril
Excited to share our new preprint on BioRxiv!
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons
Background. Paramecia belong to the ciliate phylum of unicellular eukaryotes characterized by nuclear dimorphism. A diploid germline micronucleus (MIC) transmits genetic information across sexual gene...
www.biorxiv.org
November 10, 2025 at 9:21 AM
Excited to share our new preprint on BioRxiv!
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1...
1/5
Reposted by Toby Baril
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
A comparative analysis of transposable element diversity and evolution across 75 bee genomes - BMC Genomics
Transposable elements (TEs) are repetitive DNA sequences that can alter their position and abundance within genomes. While TEs are known to have various impacts on genome structure and function, our u...
doi.org
November 6, 2025 at 1:29 PM
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
High-Quality Genome Assembly of Diplocarpon coronariae Unveils LTR Retrotransposon-Driven Structural Dynamics in Fungi Evolution
doi.org/10.1111/1755...
#TEworldwide #TEsky
doi.org/10.1111/1755...
#TEworldwide #TEsky
High‐Quality Genome Assembly of Diplocarpon coronariae Unveils LTR Retrotransposon‐Driven Structural Dynamics in Fungi Evolution
Long terminal repeat retrotransposons (LTR-RTs) are recognised as a significant evolutionary force capable of shaping the structure and function of the genomes in eukaryotes, including animals, plant...
doi.org
November 6, 2025 at 8:27 AM
High-Quality Genome Assembly of Diplocarpon coronariae Unveils LTR Retrotransposon-Driven Structural Dynamics in Fungi Evolution
doi.org/10.1111/1755...
#TEworldwide #TEsky
doi.org/10.1111/1755...
#TEworldwide #TEsky
Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌
November 6, 2025 at 8:26 AM
Reposted by Toby Baril
Thrilled to be at @embl.org in Heidelberg for #EMBOMobileGenome workshop — an inspiring gathering of the transposable element community!
Find me at poster #54, exploring DNA methylation of L1 and Alu in individuals with varying benzene exposure.
#TEworldwide #TEsky
Find me at poster #54, exploring DNA methylation of L1 and Alu in individuals with varying benzene exposure.
#TEworldwide #TEsky
November 5, 2025 at 4:30 PM
Thrilled to be at @embl.org in Heidelberg for #EMBOMobileGenome workshop — an inspiring gathering of the transposable element community!
Find me at poster #54, exploring DNA methylation of L1 and Alu in individuals with varying benzene exposure.
#TEworldwide #TEsky
Find me at poster #54, exploring DNA methylation of L1 and Alu in individuals with varying benzene exposure.
#TEworldwide #TEsky
Reposted by Toby Baril
#TEsky Evolution of Mutator transposons in the genomes of worms doi.org/10.1016/j.ge...
Redirecting
doi.org
November 5, 2025 at 3:10 PM
#TEsky Evolution of Mutator transposons in the genomes of worms doi.org/10.1016/j.ge...
Reposted by Toby Baril
☕ Coffee break time at #EMBOMobileGenome!
Inspiring talks, lively discussions, and plenty of caffeine to keep the ideas flowing. The sun’s out, the conversations are buzzing, and tonight we’ll keep the networking going with rooftop lounge drinks 🍂🍁
Looking forward to an exciting week ahead! 🧬
Inspiring talks, lively discussions, and plenty of caffeine to keep the ideas flowing. The sun’s out, the conversations are buzzing, and tonight we’ll keep the networking going with rooftop lounge drinks 🍂🍁
Looking forward to an exciting week ahead! 🧬
November 4, 2025 at 4:32 PM
☕ Coffee break time at #EMBOMobileGenome!
Inspiring talks, lively discussions, and plenty of caffeine to keep the ideas flowing. The sun’s out, the conversations are buzzing, and tonight we’ll keep the networking going with rooftop lounge drinks 🍂🍁
Looking forward to an exciting week ahead! 🧬
Inspiring talks, lively discussions, and plenty of caffeine to keep the ideas flowing. The sun’s out, the conversations are buzzing, and tonight we’ll keep the networking going with rooftop lounge drinks 🍂🍁
Looking forward to an exciting week ahead! 🧬
At @embo.org #EMBOMobileGenome and want to connect with other TE researchers and follow the latest goings on?
Use #TEworldwide and #TEsky in your posts to be featured in the TEworldwide feed, which you can also find here:
bsky.app/profile/did:...
Use #TEworldwide and #TEsky in your posts to be featured in the TEworldwide feed, which you can also find here:
bsky.app/profile/did:...
November 5, 2025 at 5:14 AM
At @embo.org #EMBOMobileGenome and want to connect with other TE researchers and follow the latest goings on?
Use #TEworldwide and #TEsky in your posts to be featured in the TEworldwide feed, which you can also find here:
bsky.app/profile/did:...
Use #TEworldwide and #TEsky in your posts to be featured in the TEworldwide feed, which you can also find here:
bsky.app/profile/did:...
great to be at the #EMBOMobileGenome meeting in Heidelberg with a wonderful bunch of colleagues, speakers and attendees.
this meeting is a good reflection of the excitement and collegiality in the transposon field.
kindly sponsored by @embo.org
this meeting is a good reflection of the excitement and collegiality in the transposon field.
kindly sponsored by @embo.org
Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers:
🔹Déborah Bourc'his
🔹Josefa González
🔹Joseph Peters
#EMBOMobileGenome
November 4, 2025 at 8:42 PM
Time to kick off #EMBOMobileGenome for 2025! A great selection of speakers and posters on the agenda!
#TEWorldwide #TESky
#TEWorldwide #TESky
November 4, 2025 at 12:32 PM
Time to kick off #EMBOMobileGenome for 2025! A great selection of speakers and posters on the agenda!
#TEWorldwide #TESky
#TEWorldwide #TESky
Reposted by Toby Baril
Transposable elements (TEs) do more than regulate genes; they help shape and preserve 3D genome structure across species.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Co-opted transposons help perpetuate conserved higher-order chromosomal structures
Transposable elements (TEs) make up half of mammalian genomes and shape genome regulation by harboring binding sites for regulatory factors. These include binding sites for architectural proteins, such as CTCF, RAD21, and SMC3, that are involved in ...
pmc.ncbi.nlm.nih.gov
October 29, 2025 at 7:31 PM
Transposable elements (TEs) do more than regulate genes; they help shape and preserve 3D genome structure across species.
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Uncover the science behind it: pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Toby Baril
@tobybarilbio.bsky.social and I are very excited to release MycoMobilome! A very extensive effort to discover, QC and annotate TEs across the fungal kingdom.
👉 Ready-to-use for your own genome with a simple tutorial!
👉 Metadata about TEs discovered in your genome!
👉 Contribute and get recognition!
👉 Ready-to-use for your own genome with a simple tutorial!
👉 Metadata about TEs discovered in your genome!
👉 Contribute and get recognition!
1/ Ever needed to annotate TEs in a fungal genome, but didn't know where to start?
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
October 29, 2025 at 4:32 PM
@tobybarilbio.bsky.social and I are very excited to release MycoMobilome! A very extensive effort to discover, QC and annotate TEs across the fungal kingdom.
👉 Ready-to-use for your own genome with a simple tutorial!
👉 Metadata about TEs discovered in your genome!
👉 Contribute and get recognition!
👉 Ready-to-use for your own genome with a simple tutorial!
👉 Metadata about TEs discovered in your genome!
👉 Contribute and get recognition!
1/ Ever needed to annotate TEs in a fungal genome, but didn't know where to start?
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
October 29, 2025 at 9:02 AM
1/ Ever needed to annotate TEs in a fungal genome, but didn't know where to start?
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
Come and join our team! A 2-year postdoc position is available in our "Genome Evolution" department at Univ Paris Saclay. We want to play with phylogenetic models accounting for horizontal transfers of transposable elements. Application& details on the official portal: emploi.cnrs.fr/Offres/CDD/U...
October 10, 2025 at 6:54 PM
Reposted by Toby Baril
"(...) an extremely large transposon, Teratorn, containing a herpesvirus genome, was inserted into the hoxc12a 3' UTR. This insertion decreased hoxc12a expression & (...) also affected neighboring hox genes, resulting in variations in fin size and the presence or absence of dorsal fins."
The phenotypic variation of widefins medaka is due to the insertion of a giant transposon containing a viral genome within hoxca cluster
Abstract. Phenotypic variation in species arises from genetic differences and environmental influences on gene expression. Differences in epigenetic modifi
academic.oup.com
October 9, 2025 at 8:30 AM
"(...) an extremely large transposon, Teratorn, containing a herpesvirus genome, was inserted into the hoxc12a 3' UTR. This insertion decreased hoxc12a expression & (...) also affected neighboring hox genes, resulting in variations in fin size and the presence or absence of dorsal fins."
Reposted by Toby Baril
#TEsky RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
October 7, 2025 at 12:10 PM
#TEsky RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation doi.org/10.1073/pnas...
Reposted by Toby Baril
The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...
Technician III - Department of Microbiology
Position Summary This position will be in the lab of Dr. Joseph E. Peters in the Department of Microbiology. Research in the Peters’ lab broadly involves deciphering mechanisms in genome stability and...
cornell.wd1.myworkdayjobs.com
October 3, 2025 at 1:01 PM
The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...
Reposted by Toby Baril
Thrilled to share what we learned from re-annotating the mobilome of the brown algae model [Ectocarpus] 🌊🌿🏖️
genomebiology.biomedcentral.com/articles/10....
A wonderful collaboration with @ericadinatale.bsky.social, @cssmartinho.bsky.social, @rorycraig.bsky.social, and Susana Coelho! 🎉
genomebiology.biomedcentral.com/articles/10....
A wonderful collaboration with @ericadinatale.bsky.social, @cssmartinho.bsky.social, @rorycraig.bsky.social, and Susana Coelho! 🎉
October 2, 2025 at 9:06 AM
Thrilled to share what we learned from re-annotating the mobilome of the brown algae model [Ectocarpus] 🌊🌿🏖️
genomebiology.biomedcentral.com/articles/10....
A wonderful collaboration with @ericadinatale.bsky.social, @cssmartinho.bsky.social, @rorycraig.bsky.social, and Susana Coelho! 🎉
genomebiology.biomedcentral.com/articles/10....
A wonderful collaboration with @ericadinatale.bsky.social, @cssmartinho.bsky.social, @rorycraig.bsky.social, and Susana Coelho! 🎉
Reposted by Toby Baril
Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky
September 16, 2025 at 6:13 AM
Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky
Reposted by Toby Baril
💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 8, 2025 at 7:42 PM
💥 New preprint! 💥
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
We show that transposons are directly linked to a cell-type and region specific inflammatory state in Parkinson’s Disease 🧠🦠
What a team @jakobssonasap.bsky.social! Funded by @asapresearch.parkinsonsroadmap.org
#Parkinsons #Neuroinflammation #TEworldwide #singlecell #TEs
Reposted by Toby Baril
Red devil spiders from the Canary Islands have a genome half the size of mainland counterparts - Pisarenco, @jrozasub.bsky.social et al. show how purifying selection against slightly deleterious DNA and TE insertions is the primary mechanism.
🔗 doi.org/10.1093/molbev/msaf206
#evobio #molbio #TEsky
🔗 doi.org/10.1093/molbev/msaf206
#evobio #molbio #TEsky
How Did Evolution Halve Genome Size During an Oceanic Island Colonization?
Abstract. Red devil spiders of the genus Dysdera colonized the Canary Islands and underwent an extraordinary diversification. Notably, their genomes are ne
doi.org
September 5, 2025 at 2:52 PM
Red devil spiders from the Canary Islands have a genome half the size of mainland counterparts - Pisarenco, @jrozasub.bsky.social et al. show how purifying selection against slightly deleterious DNA and TE insertions is the primary mechanism.
🔗 doi.org/10.1093/molbev/msaf206
#evobio #molbio #TEsky
🔗 doi.org/10.1093/molbev/msaf206
#evobio #molbio #TEsky
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 10:20 AM
Reposted by Toby Baril
@robinaraya.bsky.social @naturalselection.bsky.social @kjetillsj.bsky.social et al. investigate TEs in four large inversions in Atlantic cod - TEs accumulate in breakpoints, suggesting they drive inversions through ectopic recombination.
🔗 doi.org/10.1093/gbe/evaf131
#genome #evolution #TEsky
🔗 doi.org/10.1093/gbe/evaf131
#genome #evolution #TEsky
Chromosomal Inversions Mediated by Tandem Insertions of Transposable Elements
Abstract. Chromosomal inversions play a crucial role in evolution by influencing phenotypes through the linkage of coadapted alleles. While inversions have
doi.org
August 22, 2025 at 11:14 AM
@robinaraya.bsky.social @naturalselection.bsky.social @kjetillsj.bsky.social et al. investigate TEs in four large inversions in Atlantic cod - TEs accumulate in breakpoints, suggesting they drive inversions through ectopic recombination.
🔗 doi.org/10.1093/gbe/evaf131
#genome #evolution #TEsky
🔗 doi.org/10.1093/gbe/evaf131
#genome #evolution #TEsky
I'm super bummed to be missing #ESEB2025 @eseb2025.bsky.social due to a cancelled flight! Here's a quick overview of my talk "Gene- and genome-focused perspectives on microbial pangenomes" slated to be part of The Evolution of Microbial Pangenomes -- which I recommend you attend tomorrow (Fri) !
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August 21, 2025 at 8:44 PM