Toby Plowman
@tobiasplowman.bsky.social
PhD student in Retroviral Immunology at the Francis Crick Institute
London • https://www.crick.ac.uk/research/find-a-researcher/tobias-plowman
London • https://www.crick.ac.uk/research/find-a-researcher/tobias-plowman
Reposted by Toby Plowman
In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!
Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
Co-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.
www.science.org
July 4, 2025 at 11:17 PM
In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!
Reposted by Toby Plowman
Type 2 immunity is thought of as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective. Could it be harness to reimagine cancer immunotherapies?
🧪
@nature.com
@natureportfolio.bsky.social
www.nature.com/articles/s41...
🧪
@nature.com
@natureportfolio.bsky.social
www.nature.com/articles/s41...
Reinventing type 2 immunity in cancer - Nature
This Review addresses the roles of type 2 immunity in cancer and the potential for cancer immunotherapies targeting this pathway.
www.nature.com
January 9, 2025 at 7:53 AM
Type 2 immunity is thought of as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective. Could it be harness to reimagine cancer immunotherapies?
🧪
@nature.com
@natureportfolio.bsky.social
www.nature.com/articles/s41...
🧪
@nature.com
@natureportfolio.bsky.social
www.nature.com/articles/s41...
Reposted by Toby Plowman
Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different...
#Immunosky #Immunology
www.science.org/doi/epdf/10....
#Immunosky #Immunology
www.science.org/doi/epdf/10....
Architecture of the high-affinity immunoglobulin E receptor
Structural analysis reveals species-specific differences in how the antibody IgE binds to its receptor FcεRI.
www.science.org
December 16, 2024 at 10:46 AM
Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different...
#Immunosky #Immunology
www.science.org/doi/epdf/10....
#Immunosky #Immunology
www.science.org/doi/epdf/10....
Reposted by Toby Plowman
Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :)
December 12, 2024 at 6:14 AM
Association of polygenic scores for neuropsychiatric traits with self-reported professions based on analysis of 420k individuals from UK Biobank and Million Veteran Program. Look at the 'arts & design' category. Artistic talent comes at a cost--a piece of your mind :)
Reposted by Toby Plowman
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Toby Plowman
Reposted by Toby Plowman
A cell photographed through a microscope. DNA in the nucleus (cyan), the powerhouses/overlords of the cell, mitochondria (yellow), and actin filaments (magenta) are shown. #Science #Biology #CellBiology #microscopy
December 9, 2024 at 11:54 PM
A cell photographed through a microscope. DNA in the nucleus (cyan), the powerhouses/overlords of the cell, mitochondria (yellow), and actin filaments (magenta) are shown. #Science #Biology #CellBiology #microscopy
Reposted by Toby Plowman
Nice summary of the cool paper by @poholeklab.bsky.social's lab on IL-2 microniches in Th2 cell differentiation #ImmunoSky
It’s the little things in life: Lymph node microniches drive TH2 formation in allergic asthma
Lymph node IL-2 microniches guide development of TH2 cells through induction of Blimp-1 expression and an IL-10–positive feedback loop.
www.science.org
December 9, 2024 at 3:03 PM
Nice summary of the cool paper by @poholeklab.bsky.social's lab on IL-2 microniches in Th2 cell differentiation #ImmunoSky