Timothy En Haw Chan
@timothykoala.bsky.social
👨🔬 PhD IMPRS-IEM @UniFreiburg @mpi_ie
focus on #epigenetics #cancer #TXPN #synbio.
social network = online archive for interesting discoveries.
focus on #epigenetics #cancer #TXPN #synbio.
social network = online archive for interesting discoveries.
Molecular determinants for recognition of serotonylated chromatin
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Molecular determinants for recognition of serotonylated chromatin
Abstract. Post-translational modifications of histone tails constitute a key epigenetic mechanism controlling chromatin environment and gene transcription.
academic.oup.com
October 13, 2025 at 12:12 PM
Molecular determinants for recognition of serotonylated chromatin
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Contrasting roles of MLL3 and MLL4 histone methyltransferases in breast cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Contrasting roles of KMT2C and KMT2D in breast cancer - Scientific Reports
Scientific Reports - Contrasting roles of KMT2C and KMT2D in breast cancer
www.nature.com
October 13, 2025 at 11:41 AM
Contrasting roles of MLL3 and MLL4 histone methyltransferases in breast cancer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Requirements for establishment and epigenetic stability of mammalian heterochromatin.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Requirements for establishment and epigenetic stability of mammalian heterochromatin
Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian
cells. Using a synthetic heterochromatin assembly system and genetic screens, they
uncover requirements for init...
www.cell.com
September 21, 2025 at 10:44 PM
Requirements for establishment and epigenetic stability of mammalian heterochromatin.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Timothy En Haw Chan
Online Now: Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Taghbalout et al. apply collections of advanced multi-omics analyses to substantiate ecDNA’s mobile enhancer model in diverse types of cancer models, reveal the MED1-ecDNA condensates and establish their causal links to the modulation of oncogenic expression and cell proliferation. This study offers a chromatin-based mechanism of ecDNA function in cancer.
dlvr.it
September 19, 2025 at 11:52 AM
Online Now: Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Reposted by Timothy En Haw Chan
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle stem cells and imparts an epigenetic response that enhances their capacity for repair after injury and transplantation.
dlvr.it
July 4, 2025 at 2:10 PM
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Reposted by Timothy En Haw Chan
With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF
Pan-viral ORFs discovery using massively parallel ribosome profiling
Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...
scim.ag
June 20, 2025 at 6:20 PM
With the help of a technique called Massively Parallel Ribosome Profiling, researchers in Science have identified more than 4000 open reading frames—stretches of genetic material that can encode proteins—across 679 human-associated viral genomes. scim.ag/43RoAdF
Research about host-microbiome co-evolution on fungal infection in indigenous Malaysians, done by University of Malaya and NIH, on Cell.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians
Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment,
and transmission routes of the skin disorder tinea imbricata. Analyses of the associated
Trichophyton concen...
www.cell.com
June 19, 2025 at 11:37 AM
Research about host-microbiome co-evolution on fungal infection in indigenous Malaysians, done by University of Malaya and NIH, on Cell.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Timothy En Haw Chan
Now online! Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.
dlvr.it
May 21, 2025 at 3:00 PM
Now online! Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis
Reposted by Timothy En Haw Chan
👀Preview for Lane et al: Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy by Anjana Rao @AnjanaRaoLab, Erik Ehinger @erik_ehinger at
February 16, 2024 at 5:31 PM
👀Preview for Lane et al: Cellular reprogramming by protein degradation: The next frontier in cancer immunotherapy by Anjana Rao @AnjanaRaoLab, Erik Ehinger @erik_ehinger at
Reposted by Timothy En Haw Chan
The new issue is out! 👉 cell.com/cell/current
In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey.
📷 Credit: Currumbin Wildlife Sanctuary
In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey.
📷 Credit: Currumbin Wildlife Sanctuary
April 17, 2025 at 3:50 PM
The new issue is out! 👉 cell.com/cell/current
In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey.
📷 Credit: Currumbin Wildlife Sanctuary
In this issue of Cell, Yu et al. capture evolution of KoRV-A transcriptional silencing as the virus transitions from a pathogen to a stable endogenous retrovirus. The cover features an adult koala with a joey.
📷 Credit: Currumbin Wildlife Sanctuary
Reposted by Timothy En Haw Chan
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.
dlvr.it
April 14, 2025 at 10:38 PM
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Reposted by Timothy En Haw Chan
Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg!
📅 April 24, 2025, 14:00-19:00 PM
📌 Max Planck Institute, Freiburg (only on-site!)
🛠️ Organized by: @iovino-lab.bsky.social
Register & join free of charge.
📅 April 24, 2025, 14:00-19:00 PM
📌 Max Planck Institute, Freiburg (only on-site!)
🛠️ Organized by: @iovino-lab.bsky.social
Register & join free of charge.
Symposium: Epigenetics of early mouse development
We are delighted to invite you to to the second symposium, “Epigenetics of Early Mouse Development”, taking place on April 24, 2025, at the Max Planck Institute of Immunobiology and Epigenetics in Fre...
www.ie-freiburg.mpg.de
April 15, 2025 at 7:37 AM
Interested in the latest advancements of #epigenetics of #mammalian early embryogenesis? Then join our upcoming mini-symposium in Freiburg!
📅 April 24, 2025, 14:00-19:00 PM
📌 Max Planck Institute, Freiburg (only on-site!)
🛠️ Organized by: @iovino-lab.bsky.social
Register & join free of charge.
📅 April 24, 2025, 14:00-19:00 PM
📌 Max Planck Institute, Freiburg (only on-site!)
🛠️ Organized by: @iovino-lab.bsky.social
Register & join free of charge.
🧑🔬 Summer Research Internship opportunity focus on multi-omics technologies and AI in Precision Medicine.
🧬💻🤖💊
Molecular Medicine Research Center (MMRC) at Chang Gung University, Taiwan will offer 8 internship positions for international students.
teep.studyintaiwan.org/program/1178
🧬💻🤖💊
Molecular Medicine Research Center (MMRC) at Chang Gung University, Taiwan will offer 8 internship positions for international students.
teep.studyintaiwan.org/program/1178
TAIWAN EXPERIENCE EDUCATION PROGRAM
teep.studyintaiwan.org
April 1, 2025 at 9:26 PM
🧑🔬 Summer Research Internship opportunity focus on multi-omics technologies and AI in Precision Medicine.
🧬💻🤖💊
Molecular Medicine Research Center (MMRC) at Chang Gung University, Taiwan will offer 8 internship positions for international students.
teep.studyintaiwan.org/program/1178
🧬💻🤖💊
Molecular Medicine Research Center (MMRC) at Chang Gung University, Taiwan will offer 8 internship positions for international students.
teep.studyintaiwan.org/program/1178
Aspirin slow cancer metastasis by decrease platelet TXA2 and releasing T cells from suppression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
www.nature.com
March 6, 2025 at 7:42 PM
Aspirin slow cancer metastasis by decrease platelet TXA2 and releasing T cells from suppression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Timothy En Haw Chan
The guide I wish I had 12 years ago: a step-by-step guide to replicate a genomics paper figure divingintogeneticsandgenomics.kit.com/32726a816b
The guide I wish I had 12 years ago
divingintogeneticsandgenomics.kit.com
February 23, 2025 at 12:53 PM
The guide I wish I had 12 years ago: a step-by-step guide to replicate a genomics paper figure divingintogeneticsandgenomics.kit.com/32726a816b
Reposted by Timothy En Haw Chan
Nature research paper: Tumour-wide RNA splicing aberrations generate actionable public neoantigens
https://go.nature.com/4hTQ0UW
https://go.nature.com/4hTQ0UW
Tumour-wide RNA splicing aberrations generate actionable public neoantigens - Nature
A study identifies public neoantigens generated by tumor-wide aberrant mRNA splicing activity across distinct cancer types.
go.nature.com
February 24, 2025 at 11:06 AM
Nature research paper: Tumour-wide RNA splicing aberrations generate actionable public neoantigens
https://go.nature.com/4hTQ0UW
https://go.nature.com/4hTQ0UW
Reposted by Timothy En Haw Chan
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Rare genetic disorder treated in womb for the first time
The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.
go.nature.com
February 20, 2025 at 11:17 AM
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.
https://go.nature.com/41a7Zzj
https://go.nature.com/41a7Zzj
Reposted by Timothy En Haw Chan
In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis
Transcriptional Dosage of Oncogenic KRAS Drives Lung Adenocarcinoma Cell States, Progression and Metastasis
Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor cell state evolution. However, the molecular mechanisms underlying metastasis remain elusive...
www.biorxiv.org
December 31, 2024 at 1:12 PM
In www.biorxiv.org/content/10.1... we propose that #KRAS #dosage integrates signaling & transcription to regulate cell states, driving #heterogeneity, progression & #metastasis
Reposted by Timothy En Haw Chan
If you want to learn single-cell analysis from scratch with an user friendly, hands on, approach I very strongly recommend the series of FREE workshops offered by the SAIL team at @mskcancercenter.bsky.social , lead by @ronanchaligne.bsky.social .
sail.mskcc.org/computationa...
sail.mskcc.org/computationa...
Single-cell Data Analysis Workshop – Single-cell Analytics Innovation LabChaligne Lab Website
sail.mskcc.org
February 19, 2025 at 4:10 PM
If you want to learn single-cell analysis from scratch with an user friendly, hands on, approach I very strongly recommend the series of FREE workshops offered by the SAIL team at @mskcancercenter.bsky.social , lead by @ronanchaligne.bsky.social .
sail.mskcc.org/computationa...
sail.mskcc.org/computationa...
Reposted by Timothy En Haw Chan
Our 🔥 brand-new PhD program IMPRS-EBM at the intersection of #Epigenetics, #Biophysics & #Metabolism is open for applications📢. Looking for a fully-funded #PhDposition at Max Planck? Here is your chance: www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
January 21, 2025 at 11:23 AM
Our 🔥 brand-new PhD program IMPRS-EBM at the intersection of #Epigenetics, #Biophysics & #Metabolism is open for applications📢. Looking for a fully-funded #PhDposition at Max Planck? Here is your chance: www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
Reposted by Timothy En Haw Chan
Want to apply to our next Call for Application in collaboration with Daiichi Sankyo? Join our Infosession on 14th February 2025, at 6:00 PM CET (12:00 PM EST | 9:00 AM PST) to learn everything you need to know
us02web.zoom.us/webinar/regi...
us02web.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: Info Session: New Strategies for Proximity Induction between Novel Target Combinations in Solid Tumors. After registering, you will receive a confirmation e...
Join this info session to learn more about the open Call for Application from Daiichi Sankyo and BioMed X! Available position is Group Leader on "New Strategies for Proximity Induction between Novel T...
us02web.zoom.us
January 28, 2025 at 10:34 PM
Want to apply to our next Call for Application in collaboration with Daiichi Sankyo? Join our Infosession on 14th February 2025, at 6:00 PM CET (12:00 PM EST | 9:00 AM PST) to learn everything you need to know
us02web.zoom.us/webinar/regi...
us02web.zoom.us/webinar/regi...
Reposted by Timothy En Haw Chan
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 22, 2025 at 1:56 PM
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
Reposted by Timothy En Haw Chan
The role of the maternal X chromosome in brain aging
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
X chromosome passed from mother to daughter influences brain ageing
X-chromosome inactivation affects age-related decline in spatial memory.
www.nature.com
January 22, 2025 at 4:17 PM
The role of the maternal X chromosome in brain aging
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
Reposted by Timothy En Haw Chan
🧪Wonderful study and visualization from @lucas.farnunglab.com and @jonmarkert.bsky.social, uncovering how SETD2 - an important but challenging cancer drug target - interacts with chromatin to catalyze H3K36me3. Congratulations to all involved!
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social!
tinyurl.com/setd2
tinyurl.com/setd2
December 13, 2024 at 2:44 PM
🧪Wonderful study and visualization from @lucas.farnunglab.com and @jonmarkert.bsky.social, uncovering how SETD2 - an important but challenging cancer drug target - interacts with chromatin to catalyze H3K36me3. Congratulations to all involved!
Reposted by Timothy En Haw Chan
How can we track age-related changes of the ovary, testes and reproductive system? A new review @natureaging.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...
December 13, 2024 at 4:20 PM
How can we track age-related changes of the ovary, testes and reproductive system? A new review @natureaging.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43...