Nice! retail therapy unlocked :D

(a) strong contender, but consider the competition still open!
(b) please tell me how to get hold of that bird thermos?

Congratulations Kristin Alf Andre & all! this is a huge one :D
#fluorescencefriday #chembio

Please folks save the date for 2nd half of September 2027 - hopefully our "Quo Vadis Photoswitches" critical meeting in Frankfurt will get the greenlight & it seems you'd belong! #molswitch #photopharma

Preaching to the choir...

Dirty uses of clean compounds are just as bad as the outright PAINS.

Why is it still not mandatory for all (bio, med, pharm) chemists to get educated on (a) bringing in robust control compounds; (b) cosolvents & the kinetics of solubility; (c) high-quality probes?

The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!

Congrats to the CHalo Crew - Philipp Mauker, Carmen, Lucas, Luciano, @joycemeiri.bsky.social , @redoxlab.bsky.social , and many more;

and thanks to the many generous supporters who made it possible with reagents @kjohnsson.bsky.social , protein @lipid.bsky.social @beliulab.bsky.social , and more!

For chemists, sure: to misquote Jimmy, "it hurts how that structure just could not be any simpler."

But that's not a bug, it's a feature...

& nobody had bothered to make 4-(4-aminobutyl)-N-(3-chloropropyl)aniline until now.

What's your experience of "the simplest molecules nobody made before"?

So... @chemkritzer.bsky.social do you want to team up for the Cage1:CHalo-----------Cage2:CBz-1 heterodimeriser?

I bet a conditional Bz works similarly. Perhaps just amide => amine => carbamate?

(@PM for background info: pubs.rsc.org/en/content/a... and facultyprofiles.tufts.edu/joshua-kritz...)

Job Opp: Do you want to be the driver of those next steps as a PhD student?

If you have a strong background in synthetic chemistry & chemical biology, we want to hear from you - hiring for 2026!

tu-dresden.de/mn/chemie/oc...

I think your speaker lineup missed… no, actually, yup everyone is there 🤗🤗 Looks great, I wish I could go!!

🧵9/9
Now I am looking forward to next-gen works photocontrolling membrane permeation of diverse other species & in live: from highly polar cargos hidden in known carriers, to macromolecules, to #thiol-mediated uptake (?!) - who knows?

#lipids & #photoswitch membranes: a match made in HEaVℕ

🧵8/n
& hats off to the lipid #photoswitch academics (@dirktrauner.bsky.social, Klaus Groschner, James Frank, Oleksandra Tiapko, @dbkonrad.bsky.social, @fuchtermatt.bsky.social, & more) for the chemistry that means you can now just buy photo #lipids from €€ndustry (Avanti etc) to try this at home :)

🧵7/n
So: hats off to the Linz/Graz crew of Jürgen Pfeffermann, Rohit Yadav, Toma Glasnov, and Peter Pohl, who did all the hard work, and the very hard thinking that was needed in the beginning to understand what on earth was going on! It's been a pleasure to join for the ride and see it take shape.

🧵6/n
And, it opens the perspective to photocontrol membrane transit of basically any ion for which you can buy a decent ionophore, across model membranes or even cell membranes from any biological background:

all without genetic engineering. #optogenetics #chembio

🧵5/n
Leveraging the ion recognition power of small molecule chemistry should also allow rather higher ion specificity of photocurrents than #optogenetics approaches, as well as the higher currents overall.

#ephys #chembio