Happy to announce that our „newest old tool“ autoMLST2.0 is out and published. You need an accurate and easy to use tool to build #phylogenetictrees from #bacterialgenomes: academic.oup.com/nar/advance-...

Interested in engineering streptomycetes? Struggling with existing genome engineering tools? Then check out our newest paper on CASCADE-Cas3 based genome engineering in streptomycetes!

Some highlights below:

We are excited to see our review published! In it, we explore the diversity of enzymatic strategies for installing aromatic side chain cross-links in RiPPs. If you like interesting chemistry and new enzyme reactions, be sure to check it out!

~5y ago, Barbara, Serina, @marnixmedema.bsky.social & I teamed up to make a better NRPS A-domain specificity predictor. The Challis group & others joined along the way to add some very cool insights.

Very proud of this work. Check it out now on biorxiv!

doi.org/10.1101/2025...

Just in time for the holidays

Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin
www.biorxiv.org/content/10.1...

@amerrild.bsky.social @tizianasvenningsen.bsky.social @thomastorring.bsky.social

Interesting tool alert. The thing that makes this look promising is a way to "plasmidify" biosynthetic gene clusters in their native producers. Could simplify refactoring and expression in chassis strains. #secmet

www.science.org/doi/10.1126/...

A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social.
www.biorxiv.org/content/10.1...

Adam Rivers (USDA-ARS) and I are hiring a joint postdoc to on a microfluidics and sequencing based project to better understand synthetic and natural microbiome community dynamics and generate data to build AI/ML models to infer interspp. interactions. Hit me up if interested!

Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...

Early morning and on my way to Copenhagen for the 2024 Congress in the Danish Microbiological Society #DMS2024. Looking forward to seeing friends - old and new.

Hey Natural Products folks! Do you have a favourite ontology covering natural product bioactivities? I'm trying to make MIBiG a bit more systematic for the next release and would like to avoid creating a separate ontology if at all possible. #secmet #microsky

For teaching purposes, I am looking for culture collection strains that consistently produce a known antibiotic like vancomycin , erythromycin, daptomycin or similar. Any suggestions? I’d prefer NRRL or DSMZ

#secmet folks : a teach-in in honor of Chris Walsh. All students and post-docs encouraged to attend. This is an outstanding speaker list inspired a great scientist & teacher.

Now releasing into your podcast feeds: JGI's Natural Prodcast talks to Alison Narayan (UMich) about biocatalysis and candy corn! Notes and transcripts (and in-browser audio) at naturalprodcast.com
🧪🧬🖥️ #chemsky

A good book, a cup of coffee, and PJ Harvey. This morning is off to a start

Looking forward to reading this one

On the train to Copenhagen for the iimena symposium. Looking very much forward to two days of #naturalproducts

Come work with us!! Lecturer / Senior Lecturer in Antimicrobial Drug Discovery at Newcastle University @nubiosciences! Please RT

#AMR #DrugDiscovery #NaturalProducts #Metabolomics #Microbiology www.jobs.ac.uk/job/DCX827/l...