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The Babak Lab
@thebabaklab.bsky.social
150 followers 93 following 85 posts
Research group of Prof. Maria (Masha) Babak at City University of Hong Kong

#anticancerdrugdiscovery #globalpublichealth #AI-assisteddrugdisovery

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📸 Image generated using Sora by OpenAI
Article link: www.nejm.org/doi/full/10....
Encorafenib, Cetuximab, and mFOLFOX6 in BRAF-Mutated Colorectal Cancer | NEJM
First-line treatment with encorafenib plus cetuximab (EC) with or without chemotherapy (oxaliplatin, leucovorin, and fluorouracil [mFOLFOX6]) for BRAF V600E–mutated metastatic colorectal cancer, an...
www.nejm.org
June 30, 2025 at 12:37 PM
thebabaklab.bsky.social
Check the preprint 👇
chemrxiv.org/engage/chemr...
Overcoming cisplatin resistance via deep learning-assisted de novo design of platinum complexes
Resistance to cisplatin poses a significant challenge in cancer treatment for patients globally. Despite the continuous efforts of both the pharmaceutical industry and academia, no new platinum drugs ...
chemrxiv.org
June 27, 2025 at 3:19 PM
thebabaklab.bsky.social
Article link: www.nature.com/articles/s41...
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A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists - Nature Chemistry
Large language models are increasingly used for diverse tasks, yet we have limited insight into their understanding of chemistry. Now ChemBench—a benchmarking framework containing more than 2,700 ques...
www.nature.com
June 25, 2025 at 11:29 AM
thebabaklab.bsky.social
📸 Image generated using Sora by OpenAI
Article link: www.nejm.org/doi/full/10....
Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer | NEJM
The benefit of the addition of perioperative pembrolizumab to standard care with surgery and adjuvant therapy for patients with locally advanced head and neck squamous-cell carcinoma (HNSCC) is unc...
www.nejm.org
June 23, 2025 at 9:49 AM
thebabaklab.bsky.social
Check the preprint 👇
chemrxiv.org/engage/chemr...
Overcoming cisplatin resistance via deep learning-assisted de novo design of platinum complexes
Resistance to cisplatin poses a significant challenge in cancer treatment for patients globally. Despite the continuous efforts of both the pharmaceutical industry and academia, no new platinum drugs ...
chemrxiv.org
June 21, 2025 at 1:50 PM
thebabaklab.bsky.social
Article link: nature.com/articles/s41...
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Iron at the crossroads of host–microbiome interactions in health and disease - Nature Microbiology
Choi and Bessman discuss the role of iron in host–microbiome interactions, including iron acquisition strategies by the host, commensals and pathogens, and implications for disease and therapeutics.
nature.com
June 18, 2025 at 11:18 AM
thebabaklab.bsky.social
Article link: nature.com/articles/s41...
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Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial - Nature Medicine
A single dose of the anti-sporozoite monoclonal antibody CIS43LS can achieve durable, sterile protection against Plasmodium falciparum infection.
nature.com
June 16, 2025 at 8:28 AM
thebabaklab.bsky.social
Image generated with Freepik AI (www.freepik.com)
Article link: www.nature.com/articles/s43...
Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology - Nature Cancer
Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across various clinical scenarios r...
www.nature.com
June 11, 2025 at 10:32 AM
thebabaklab.bsky.social
Article link: www.nejm.org/doi/full/10....
Tarlatamab in Small-Cell Lung Cancer after Platinum-Based Chemotherapy | NEJM
Tarlatamab, a bispecific delta-like ligand 3–directed T-cell engager immunotherapy, received accelerated approval for the treatment of patients with previously treated small-cell lung cancer. Wheth...
www.nejm.org
June 9, 2025 at 10:05 AM
thebabaklab.bsky.social
🔗 www.science.org/doi/10.1126/...
High-affinity PQQ import is widespread in Gram-negative bacteria
Diverse bacteria use the high-affinity membrane transport protein PqqU to scavenge the nutrient PQQ from the environment.
www.science.org
June 4, 2025 at 6:37 AM
thebabaklab.bsky.social
June 2, 2025 at 2:23 PM
thebabaklab.bsky.social
Pikting Izzy Cheung was chosen by an expert jury including:
🔹Mrs. Stefanie Seedig
🔹Ms. Melanie Spaethe
🔹Dr.Tiejun Meng
🔹Dr. Karlis Rokpelnis
🔹Dr. Violeta N. Ivanova-Rohling
🔹Prof. Ruiqin Zhang
🔹Dr. Yuanyuan Zhao
🔹Prof. Maria (Masha) Babak, PhD
June 2, 2025 at 2:23 PM