@teamline1.bsky.social
Reposted
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment
Methylation of CpG dinucleotides is essential for silencing genomic repeats such as LINE-1 retrotransposons (L1s) in the germline and soma. Evolutionarily-young L1s are transcribed in human pluripoten...
www.biorxiv.org
July 1, 2025 at 12:55 PM
Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social
www.biorxiv.org/content/10.1...
Brief thread below (do people still do that?) 1/X
Reposted
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted
#TEsky LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis doi.org/10.1126/scia...
LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis
ORF1p forms condensates that bind to chromosomes during cell division, allowing L1 elements to insert themselves into the genome.
doi.org
May 3, 2025 at 1:36 PM
#TEsky LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis doi.org/10.1126/scia...
Reposted
Always a treat to hear Kathy Burns - keynote speaker at #TECSHA and her groundbreaking work linking L1 retrotransposon activity to cancer. L1 ORF1p expression is a hallmark and a circulating biomarker of many cancers.
April 7, 2025 at 11:26 AM
Always a treat to hear Kathy Burns - keynote speaker at #TECSHA and her groundbreaking work linking L1 retrotransposon activity to cancer. L1 ORF1p expression is a hallmark and a circulating biomarker of many cancers.
Reposted
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
April 6, 2025 at 4:24 PM
Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social
Reposted
We are very proud that we can already present some of the publications resulting from Gevol. Check out the recent paper by Gevol member @Katja Nowick: Regulatory networks of KRAB zinc finger genes and TE changed during human brain evolution and disease. elifesciences.org/reviewed-pre...
Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease
elifesciences.org
March 31, 2025 at 9:53 AM
We are very proud that we can already present some of the publications resulting from Gevol. Check out the recent paper by Gevol member @Katja Nowick: Regulatory networks of KRAB zinc finger genes and TE changed during human brain evolution and disease. elifesciences.org/reviewed-pre...
Reposted
Check out our preprint "De-repression of Transposable Elements by Histone Hyperacetylation Leads to Sterile Inflammation in Preeclampsia" www.researchsquare.com/article/rs-6...
March 26, 2025 at 10:08 AM
Check out our preprint "De-repression of Transposable Elements by Histone Hyperacetylation Leads to Sterile Inflammation in Preeclampsia" www.researchsquare.com/article/rs-6...
Reposted
Does the smell and flavor of strawberries depend on variations in gene-associated transposons? It seems so! Check out our new preprint! www.biorxiv.org/content/10.1...
Naturally occurring variation in gene-associated transposable elements impacts gene expression and phenotypic diversity in woodland strawberry
Transposable elements (TEs) constitute a major portion of plant genomes and play key roles in shaping genome architecture, regulating gene expression, and driving genome evolution. In this study, we g...
www.biorxiv.org
March 21, 2025 at 12:57 PM
Does the smell and flavor of strawberries depend on variations in gene-associated transposons? It seems so! Check out our new preprint! www.biorxiv.org/content/10.1...
Reposted
Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
March 24, 2025 at 9:01 PM
Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky
Reposted
#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...
The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition
DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.
doi.org
March 21, 2025 at 3:14 PM
#TEsky The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition doi.org/10.7554/eLif...
Reposted
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted
In the ‘90s, Pelisson et al. found that gypsy retrotransposons in flies can go viral—literally—thanks to an envelope gene. Now, @mayavoichek.bsky.social uncovers a wild new path to retrotransposon infectivity. A fascinating story—see Maya's thread
www.biorxiv.org/content/10.1101/2025.03.14.642691v2
www.biorxiv.org/content/10.1101/2025.03.14.642691v2
March 17, 2025 at 8:28 PM
In the ‘90s, Pelisson et al. found that gypsy retrotransposons in flies can go viral—literally—thanks to an envelope gene. Now, @mayavoichek.bsky.social uncovers a wild new path to retrotransposon infectivity. A fascinating story—see Maya's thread
www.biorxiv.org/content/10.1101/2025.03.14.642691v2
www.biorxiv.org/content/10.1101/2025.03.14.642691v2
Reposted
Today's @usatoday.com front page
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
February 27, 2025 at 2:09 PM
Today's @usatoday.com front page
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
First US death from measles in 10 years
First child to die from measles in 22 years in the US
All of this fully preventable
Reposted
It's been a while because I've felt distracted lately with...*gestures at everything* but, I've gone and updated TE Hub @tehub.bsky.social with new tools, databases and TE lineages tehub.org #TEsky
TE Hub
tehub.org
February 23, 2025 at 7:28 PM
It's been a while because I've felt distracted lately with...*gestures at everything* but, I've gone and updated TE Hub @tehub.bsky.social with new tools, databases and TE lineages tehub.org #TEsky
Reposted
It was amazing to have interacted with Jeff Boeke, from NYU and also witnessed his phenomenal talk at @mdc-bimsb.bsky.social
He has now put all human chromosomes in yeast, One by one. Also, they made parrots have conversation in five languages English, French, German, Swedish and Spanish 😂
He has now put all human chromosomes in yeast, One by one. Also, they made parrots have conversation in five languages English, French, German, Swedish and Spanish 😂
February 13, 2025 at 11:30 AM
It was amazing to have interacted with Jeff Boeke, from NYU and also witnessed his phenomenal talk at @mdc-bimsb.bsky.social
He has now put all human chromosomes in yeast, One by one. Also, they made parrots have conversation in five languages English, French, German, Swedish and Spanish 😂
He has now put all human chromosomes in yeast, One by one. Also, they made parrots have conversation in five languages English, French, German, Swedish and Spanish 😂
Reposted
#TEsky LTR element insertions in MIEL1 gene in walnut genus as possible cause of red rather than yellow stigma tissue doi.org/10.1093/molb...
Genetic mechanisms and adaptive benefits of anthocyanin-red stigmas in a wind-pollinated tree
Abstract. Anthocyanin accumulation in leaves or flowers mitigates photooxidation damage from Reactive Oxygen Species (ROS) and functions in plant/animal in
doi.org
February 11, 2025 at 4:12 PM
#TEsky LTR element insertions in MIEL1 gene in walnut genus as possible cause of red rather than yellow stigma tissue doi.org/10.1093/molb...
Reposted
Don't miss the first edition of the CSH-Asia meeting on "The Repetitive and Mobile Genome" taking place in Suzhou, China.
📅 Abstract submission deadline extended: Feb 21, 2025
👉 www.csh-asia.org?content/2544
#transposon #mobileDNA #TEsky
📅 Abstract submission deadline extended: Feb 21, 2025
👉 www.csh-asia.org?content/2544
#transposon #mobileDNA #TEsky
February 7, 2025 at 4:43 PM
Don't miss the first edition of the CSH-Asia meeting on "The Repetitive and Mobile Genome" taking place in Suzhou, China.
📅 Abstract submission deadline extended: Feb 21, 2025
👉 www.csh-asia.org?content/2544
#transposon #mobileDNA #TEsky
📅 Abstract submission deadline extended: Feb 21, 2025
👉 www.csh-asia.org?content/2544
#transposon #mobileDNA #TEsky
Reposted
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:18 AM
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
Reposted
#TEsky A CACTA-like transposon in the Anthocyanidin synthase 1 (Ans-1) gene is responsible for apricot fruit colour in the raspberry (Rubus idaeus) cultivar ‘Varnes’ doi.org/10.1371/jour...
A CACTA-like transposon in the Anthocyanidin synthase 1 (Ans-1) gene is responsible for apricot fruit colour in the raspberry (Rubus idaeus) cultivar ‘Varnes’
Cultivated raspberries (Rubus idaeus L.) most commonly bear small, red, highly aromatic fruits. Their colour is derived predominantly from anthocyanins, water soluble polyphenolic pigments, but as wel...
doi.org
February 4, 2025 at 2:18 PM
#TEsky A CACTA-like transposon in the Anthocyanidin synthase 1 (Ans-1) gene is responsible for apricot fruit colour in the raspberry (Rubus idaeus) cultivar ‘Varnes’ doi.org/10.1371/jour...
Reposted
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
The mobile genome: genetic and physiological impacts of transposable elements
www.embl.org
January 27, 2025 at 7:58 AM
Dear all, registrations are open for the Mobile Genome @EMBO workshop. Many slots for posters, short talks but also long talks for last minute groundbreaking results! Let’s meet again on Nov 4-7, 2025 in Heidelberg. www.embl.org/about/info/c...
Reposted
Still looking for good locus-specific TE expression packages (TElocal)? Or single-cell/nuc RNA-seq analysis packages (TEsingle)? We've made those available prior to publication with lots of annotation files for your favorite genome build
GitHub links are at our website: www.mghlab.org/software
GitHub links are at our website: www.mghlab.org/software
Software — MGH Lab
www.mghlab.org
November 18, 2024 at 11:41 PM
Still looking for good locus-specific TE expression packages (TElocal)? Or single-cell/nuc RNA-seq analysis packages (TEsingle)? We've made those available prior to publication with lots of annotation files for your favorite genome build
GitHub links are at our website: www.mghlab.org/software
GitHub links are at our website: www.mghlab.org/software
Reposted
TEsmall has also been out for a while: www.frontiersin.org/journals/gen...
TEsmall lets you look at all the different types of small RNAs in your data: microRNAs as well as the wild world of other small RNA products including tRNA fragments, piRNAs, and TE-derived siRNAs - with nice QC graphs
TEsmall lets you look at all the different types of small RNAs in your data: microRNAs as well as the wild world of other small RNA products including tRNA fragments, piRNAs, and TE-derived siRNAs - with nice QC graphs
Frontiers | TEsmall Identifies Small RNAs Associated With Targeted Inhibitor Resistance in Melanoma
MicroRNAs (miRNAs) are small 21–22 nt RNAs that act to regulate the expression of mRNA target genes through direct binding to mRNA targets. While miRNAs typi...
www.frontiersin.org
November 18, 2024 at 11:39 PM
TEsmall has also been out for a while: www.frontiersin.org/journals/gen...
TEsmall lets you look at all the different types of small RNAs in your data: microRNAs as well as the wild world of other small RNA products including tRNA fragments, piRNAs, and TE-derived siRNAs - with nice QC graphs
TEsmall lets you look at all the different types of small RNAs in your data: microRNAs as well as the wild world of other small RNA products including tRNA fragments, piRNAs, and TE-derived siRNAs - with nice QC graphs
Reposted
TEtranscripts was published a while ago: academic.oup.com/bioinformati...
TEtranscripts is a great all-purpose gene and TE RNA expression package that produces joint gene & TE count tables. Working with genes & TEs simultaneously helps distinguish real TE expression from overlapping gene reads
TEtranscripts is a great all-purpose gene and TE RNA expression package that produces joint gene & TE count tables. Working with genes & TEs simultaneously helps distinguish real TE expression from overlapping gene reads
TEtranscripts: a package for including transposable elements in differential expression analysis of RNA-seq datasets
Abstract. Motivation: Most RNA-seq data analysis software packages are not designed to handle the complexities involved in properly apportioning short sequ
academic.oup.com
November 18, 2024 at 11:34 PM
TEtranscripts was published a while ago: academic.oup.com/bioinformati...
TEtranscripts is a great all-purpose gene and TE RNA expression package that produces joint gene & TE count tables. Working with genes & TEs simultaneously helps distinguish real TE expression from overlapping gene reads
TEtranscripts is a great all-purpose gene and TE RNA expression package that produces joint gene & TE count tables. Working with genes & TEs simultaneously helps distinguish real TE expression from overlapping gene reads
Reposted
Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out!
www.mghlab.org/software
www.mghlab.org/software
November 18, 2024 at 11:14 PM
Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out!
www.mghlab.org/software
www.mghlab.org/software