We demonstrate TOAST on tasks of intra-, intersample, and temporal alignment in:
🧠 Human cortical layers (Visium)
🧫 Axolotl regeneration (Stereo-seq)
🐭 Locallization in mouse embryo development (seqFISH)
🎯 Various cancer types (IMC)
... with state-of-the-art efficiency and performance.

Alignment is an important step for data integration and transfer of information that can help gain insights into mechanisms, progression and structural changes in disease. When the spatial context is available it *has to* complement molecular similarity to yield more biologically plausible mappings.

🚨 New preprint: Topography Aware Optimal Transport for Alignment of Spatial Omics Data

We present our new alignment framework TOAST www.biorxiv.org/content/10.1...