Tabea Schoeler
@tabeasch.bsky.social
Researcher at University of Lausanne | interested in genetic epidemiology, mental health & behaviour
Pinned
Tabea Schoeler
@tabeasch.bsky.social
· Jul 8
Design and model choices shape inference of age-varying genetic effects on complex traits
Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...
shorturl.at
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Reposted by Tabea Schoeler
How many preregistered studies end up in the file drawer? 🗂️
Join us to find out from Eline Ensinck at the next ReproducibiliTea!
📅Nov 25, 3pm GMT
www.eventbrite.co.uk/e/are-prereg...
@tabeasch.bsky.social @reproducibilitea.org @uclopenscience.bsky.social @ukrepro.bsky.social @lakens.bsky.social
Join us to find out from Eline Ensinck at the next ReproducibiliTea!
📅Nov 25, 3pm GMT
www.eventbrite.co.uk/e/are-prereg...
@tabeasch.bsky.social @reproducibilitea.org @uclopenscience.bsky.social @ukrepro.bsky.social @lakens.bsky.social
Are Preregistered Studies Publicly Shared? With Eline Ensinck
Eline Ensinck will present research on the number of preregistered studies which are never published and the reasons behind this
www.eventbrite.co.uk
November 11, 2025 at 1:02 PM
How many preregistered studies end up in the file drawer? 🗂️
Join us to find out from Eline Ensinck at the next ReproducibiliTea!
📅Nov 25, 3pm GMT
www.eventbrite.co.uk/e/are-prereg...
@tabeasch.bsky.social @reproducibilitea.org @uclopenscience.bsky.social @ukrepro.bsky.social @lakens.bsky.social
Join us to find out from Eline Ensinck at the next ReproducibiliTea!
📅Nov 25, 3pm GMT
www.eventbrite.co.uk/e/are-prereg...
@tabeasch.bsky.social @reproducibilitea.org @uclopenscience.bsky.social @ukrepro.bsky.social @lakens.bsky.social
Reposted by Tabea Schoeler
Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social
October 14, 2025 at 11:18 AM
Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social
Reposted by Tabea Schoeler
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health.
3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!
🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!
🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
Research Fellow in Mental Health at UCL
Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
www.jobs.ac.uk
October 10, 2025 at 9:41 AM
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health.
3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!
🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science!
🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
Reposted by Tabea Schoeler
When is it appropriate to deviate from a pre-registration, and how should this be done? 🧐
Join us to find out from Daniël Lakens @lakens.bsky.social at the next ReproducibiliTea!
October 28, 1pm GMT.
Sign up: www.eventbrite.co.uk/e/when-and-h...
@tabeasch.bsky.social @reproducibilitea.org
Join us to find out from Daniël Lakens @lakens.bsky.social at the next ReproducibiliTea!
October 28, 1pm GMT.
Sign up: www.eventbrite.co.uk/e/when-and-h...
@tabeasch.bsky.social @reproducibilitea.org
When and How to Deviate From a Preregistration, with Prof Daniël Lakens
Prof Daniël Lakens will share guidance on appropriate circumstances and methods for deviating from a pre-registration
www.eventbrite.co.uk
October 13, 2025 at 10:41 AM
When is it appropriate to deviate from a pre-registration, and how should this be done? 🧐
Join us to find out from Daniël Lakens @lakens.bsky.social at the next ReproducibiliTea!
October 28, 1pm GMT.
Sign up: www.eventbrite.co.uk/e/when-and-h...
@tabeasch.bsky.social @reproducibilitea.org
Join us to find out from Daniël Lakens @lakens.bsky.social at the next ReproducibiliTea!
October 28, 1pm GMT.
Sign up: www.eventbrite.co.uk/e/when-and-h...
@tabeasch.bsky.social @reproducibilitea.org
Reposted by Tabea Schoeler
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
September 26, 2025 at 5:10 PM
🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...
Reposted by Tabea Schoeler
Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!
New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling - Nature Genetics
Multivariate genome-wide association analyses of the latent genetic architecture of frailty identify one general factor of genetic overlap across all frailty deficits and six factors indexing a shared...
www.nature.com
August 6, 2025 at 4:16 PM
Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!
Reposted by Tabea Schoeler
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Design and model choices shape inference of age-varying genetic effects on complex traits
Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...
shorturl.at
July 8, 2025 at 12:47 PM
🚨New preprint is out!
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
shorturl.at/17snd
A thread 🧵👇
Reposted by Tabea Schoeler
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
July 4, 2025 at 8:52 AM
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
Reposted by Tabea Schoeler
READING RECOMMENDATION 📖 Genes, environment, and aging: What determines cognitive and physical decline?
Using newly available longitudinal aging data from the UK Biobank, @tabeasch.bsky.social and colleagues uncovered genetic and environmental factors influencing cognitive and physical decline.
Using newly available longitudinal aging data from the UK Biobank, @tabeasch.bsky.social and colleagues uncovered genetic and environmental factors influencing cognitive and physical decline.
Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications
The genetics of human aging remains poorly understood due to limited longitudinal data. Here, the authors show distinct genetic architectures for baseline function and decline in cognitive and physica...
www.nature.com
June 24, 2025 at 1:53 PM
READING RECOMMENDATION 📖 Genes, environment, and aging: What determines cognitive and physical decline?
Using newly available longitudinal aging data from the UK Biobank, @tabeasch.bsky.social and colleagues uncovered genetic and environmental factors influencing cognitive and physical decline.
Using newly available longitudinal aging data from the UK Biobank, @tabeasch.bsky.social and colleagues uncovered genetic and environmental factors influencing cognitive and physical decline.
Reposted by Tabea Schoeler
🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource.
Spread the good news!
osf.io/preprints/os...
Spread the good news!
osf.io/preprints/os...
OSF
osf.io
June 13, 2025 at 5:51 PM
🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource.
Spread the good news!
osf.io/preprints/os...
Spread the good news!
osf.io/preprints/os...
Reposted by Tabea Schoeler
🧠🧬🧑🤝🧑 New CoDE Lab study: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning. Link to preprint: www.medrxiv.org/content/10.1... Led by the brilliant Wangjingyi Liao 🌟
A short thread summarising the study👇
A short thread summarising the study👇
June 10, 2025 at 9:51 AM
🧠🧬🧑🤝🧑 New CoDE Lab study: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning. Link to preprint: www.medrxiv.org/content/10.1... Led by the brilliant Wangjingyi Liao 🌟
A short thread summarising the study👇
A short thread summarising the study👇
Reposted by Tabea Schoeler
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
May 20, 2025 at 10:14 AM
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
Reposted by Tabea Schoeler
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1
May 20, 2025 at 10:18 AM
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants!
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications
Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Bioban...
shorturl.at
May 19, 2025 at 12:29 PM
Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants!
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline
(1/)🧵🧵
shorturl.at/99gqL
Reposted by Tabea Schoeler
On June 6th, I'll be giving a keynote talk at the Swiss Federal Office for Public Health!
It's part of a one day workshop on the benefits and challenges in communicating long-term data in public health 📈📊📉
Join if you can! ☺️
It's part of a one day workshop on the benefits and challenges in communicating long-term data in public health 📈📊📉
Join if you can! ☺️
May 8, 2025 at 4:13 PM
On June 6th, I'll be giving a keynote talk at the Swiss Federal Office for Public Health!
It's part of a one day workshop on the benefits and challenges in communicating long-term data in public health 📈📊📉
Join if you can! ☺️
It's part of a one day workshop on the benefits and challenges in communicating long-term data in public health 📈📊📉
Join if you can! ☺️
Reposted by Tabea Schoeler
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
www.nature.com
May 7, 2025 at 4:30 PM
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
Reposted by Tabea Schoeler
Very excited to give a virtual talk as part of the
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
April 29, 2025 at 4:06 PM
Very excited to give a virtual talk as part of the
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
@eshg.bsky.social
webinar series tomorrow at 4pm (CEST). If you want to listen in, register here: wma.eventsair.com/eshg-webinar... I will talk about all the exciting things we can learn from GWAS summary statistics...
Reposted by Tabea Schoeler
Come work with us! We're looking of postdoc(s) with experience in bacterial genomics and interest in mathematical modelling to work on bacterial ecology and evolution in the context of public health. tinyurl.com/n34vzszu
Opportunités de carrière : Postdoctoral researcher in bacterial genomics (22209)
tinyurl.com
April 28, 2025 at 5:54 PM
Come work with us! We're looking of postdoc(s) with experience in bacterial genomics and interest in mathematical modelling to work on bacterial ecology and evolution in the context of public health. tinyurl.com/n34vzszu
Reposted by Tabea Schoeler
The recording of the second episode of our #ESHG Webinar Series is now on YouTube.
🔜 Episode 3 – April 30, 16:00 CEST
📌 "Making sense of genetic associations"
🎙️ Zoltan Kutalik
Join for free on Zoom! Register here: buff.ly/l6d0fai
🔜 Episode 3 – April 30, 16:00 CEST
📌 "Making sense of genetic associations"
🎙️ Zoltan Kutalik
Join for free on Zoom! Register here: buff.ly/l6d0fai
April 3, 2025 at 1:26 PM
The recording of the second episode of our #ESHG Webinar Series is now on YouTube.
🔜 Episode 3 – April 30, 16:00 CEST
📌 "Making sense of genetic associations"
🎙️ Zoltan Kutalik
Join for free on Zoom! Register here: buff.ly/l6d0fai
🔜 Episode 3 – April 30, 16:00 CEST
📌 "Making sense of genetic associations"
🎙️ Zoltan Kutalik
Join for free on Zoom! Register here: buff.ly/l6d0fai
Reposted by Tabea Schoeler
We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
April 1, 2025 at 8:12 PM
We study the genetics of drug efficacy using longitudinal biomarker and medication prescription data from #EHRs. 🧬💊
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
Have a look at the 🧵 on i) modelling drug response and biomarker progression, ii) using #PRS to predict efficacy and iii) the challenges with #EHRs.
www.nature.com/articles/s41...
Reposted by Tabea Schoeler
Our work on intergenerational transmission of psychiatric risk is now out!! www.nature.com/articles/s41... @naturecomms.bsky.social with thanks to my super coauthors @leofrach.bsky.social @jessiebaldwin.bsky.social and several others who made this possible
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood - Nature Communications
Parental neuropsychiatric traits relate to children’s emotions and behaviours beyond genetic transmission alone. Here the author's findings suggest potential environmental risk factors that can act on...
www.nature.com
March 20, 2025 at 3:44 PM
Our work on intergenerational transmission of psychiatric risk is now out!! www.nature.com/articles/s41... @naturecomms.bsky.social with thanks to my super coauthors @leofrach.bsky.social @jessiebaldwin.bsky.social and several others who made this possible
Reposted by Tabea Schoeler
Join us in Lausanne for a newly launched Computational Biology Symposium with a stellar lineup of speakers! Registration and abstract submission open: share your original research work in a friendly atmosphere!
March 19, 2025 at 1:23 PM
Join us in Lausanne for a newly launched Computational Biology Symposium with a stellar lineup of speakers! Registration and abstract submission open: share your original research work in a friendly atmosphere!
Reposted by Tabea Schoeler
🏆 Research integrity consultant and image forensics expert @elisabethbik.bsky.social has uncovered fraudulent data in over 7,600 scientific papers and exposed the practices of ‘paper mills’ that produce counterfeit scientific articles. She is honoured with the €200K Individual Award. Congrats!
March 14, 2025 at 10:14 PM
🏆 Research integrity consultant and image forensics expert @elisabethbik.bsky.social has uncovered fraudulent data in over 7,600 scientific papers and exposed the practices of ‘paper mills’ that produce counterfeit scientific articles. She is honoured with the €200K Individual Award. Congrats!
Reposted by Tabea Schoeler
The London Genetics Network has arrived on Bluesky! Follow us here if you'd like @ldngenenet.bsky.social
March 11, 2025 at 12:07 PM
The London Genetics Network has arrived on Bluesky! Follow us here if you'd like @ldngenenet.bsky.social