You can read the full paper here: rdcu.be/emRoj

Thank you to the brilliant team who led this effort: Zacharie Saint-Georges, Julia MacDonald, Roya Al-Khalili, Rami Hamati, Marco Solmi, Matcheri Keshavan, and @laurituominen.bsky.social. 👏
#CRANILab #MolecularImagingLab @uqo.ca @uottawa.ca @harvardmed.bsky.social

These findings are particularly interesting because the cholinergic system is a new treatment target for cognitive and clinical symptoms in schizophrenia. 🌟

We found consistent alterations across multiple components of the cholinergic system, most notably reductions in muscarinic (M1/M4) and nicotinic receptor levels. Meta-analyses showed moderate to large effects in the striatum, hippocampus, and frontal cortex.

In this work, we examined over three decades of molecular imaging and post-mortem research, synthesizing evidence from 61 studies.