Sarah Vergult
@svergult.bsky.social
PI of the Functional Genomics lab (https://fungenlab-ugent.be/) at Ghent University.
Elucidating the genetics of neurodevelopmental disorders.
Special interest in the role of the non-coding genome during neurodevelopment.
Elucidating the genetics of neurodevelopmental disorders.
Special interest in the role of the non-coding genome during neurodevelopment.
Last Friday, I had the privilege to present the latest FunGen Lab work at the Symposium of the Marguerite Marie Delacroix Foundation.
This symposium brings together researchers working on neurodevelopmental disorders, creating an inspiring environment.
Grateful to be part of this community 🌟.
This symposium brings together researchers working on neurodevelopmental disorders, creating an inspiring environment.
Grateful to be part of this community 🌟.
November 24, 2025 at 8:58 PM
Last Friday, I had the privilege to present the latest FunGen Lab work at the Symposium of the Marguerite Marie Delacroix Foundation.
This symposium brings together researchers working on neurodevelopmental disorders, creating an inspiring environment.
Grateful to be part of this community 🌟.
This symposium brings together researchers working on neurodevelopmental disorders, creating an inspiring environment.
Grateful to be part of this community 🌟.
Reposted by Sarah Vergult
👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs
📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...
Postdoctoral fellow
www.ugent.be
July 31, 2025 at 9:46 AM
👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs
📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...
Postdoctoral fellow
www.ugent.be
July 31, 2025 at 8:52 AM
📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...
📣 In our recent study, we present a minimally invasive RNA-seq protocol using short-term cultured peripheral blood mononuclear cells (PBMCs), with and without cycloheximide treatment. A big shout-out to Laurenz and Erika who were instrumental in carrying out the study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cracking rare disorders: a new minimally invasive RNA-seq protocol - npj Genomic Medicine
npj Genomic Medicine - Cracking rare disorders: a new minimally invasive RNA-seq protocol
www.nature.com
June 3, 2025 at 4:40 PM
📣 In our recent study, we present a minimally invasive RNA-seq protocol using short-term cultured peripheral blood mononuclear cells (PBMCs), with and without cycloheximide treatment. A big shout-out to Laurenz and Erika who were instrumental in carrying out the study!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excellent talk by my colleague @elfridedebaere.bsky.social on cis regulatory elements in eye diseases at #eshg25. If you did not attend her session, I highly recommend to watch it on the virtual platform. Enhanceropathies research at Ghent University is on 🔥
May 25, 2025 at 4:42 PM
Excellent talk by my colleague @elfridedebaere.bsky.social on cis regulatory elements in eye diseases at #eshg25. If you did not attend her session, I highly recommend to watch it on the virtual platform. Enhanceropathies research at Ghent University is on 🔥
Excellent flash talk by #FunGen PhD student @lisahamerlinck.bsky.social ! If you missed it, you still have the chance to check out her poster P10.003 tomorrow between 16:00-17:00. #eshg25
@lisahamerlinck.bsky.social kicking ass at #eshg2025
Sharing work on non-coding regulatory disruptions of FOXG1.
#FunGen @svergult.bsky.social @eedhaene.bsky.social
Sharing work on non-coding regulatory disruptions of FOXG1.
#FunGen @svergult.bsky.social @eedhaene.bsky.social
May 25, 2025 at 12:37 PM
Excellent flash talk by #FunGen PhD student @lisahamerlinck.bsky.social ! If you missed it, you still have the chance to check out her poster P10.003 tomorrow between 16:00-17:00. #eshg25
If you are interested in a postdoc position on neural organoids in the lovely city of Ghent, Belgium, and happen to be at #eshg25, feel free to come and have a chat with me. Or, if you know other interested people, feel free to share with them.
📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline: June 23
Link: www.ugent.be/en/work/scie...
Link: www.ugent.be/en/work/scie...
Postdoctoral fellow
www.ugent.be
May 25, 2025 at 9:02 AM
If you are interested in a postdoc position on neural organoids in the lovely city of Ghent, Belgium, and happen to be at #eshg25, feel free to come and have a chat with me. Or, if you know other interested people, feel free to share with them.
Reposted by Sarah Vergult
🗣️ Quote of #ESHG2025 (so far)
"Who licks bone !?!" 🦴
- Johannes Krause
Anyone have that on your bingo card?
Well apparently archeologists do, to distinguish bone from stones and it causes problems in DNA sequencing. 🤔
"Who licks bone !?!" 🦴
- Johannes Krause
Anyone have that on your bingo card?
Well apparently archeologists do, to distinguish bone from stones and it causes problems in DNA sequencing. 🤔
May 24, 2025 at 1:46 PM
🗣️ Quote of #ESHG2025 (so far)
"Who licks bone !?!" 🦴
- Johannes Krause
Anyone have that on your bingo card?
Well apparently archeologists do, to distinguish bone from stones and it causes problems in DNA sequencing. 🤔
"Who licks bone !?!" 🦴
- Johannes Krause
Anyone have that on your bingo card?
Well apparently archeologists do, to distinguish bone from stones and it causes problems in DNA sequencing. 🤔
Reposted by Sarah Vergult
@ahoischen.bsky.social insisting junior researchers get the mic at #ESHG2025 🎤👩🔬👨🔬
May 24, 2025 at 12:19 PM
@ahoischen.bsky.social insisting junior researchers get the mic at #ESHG2025 🎤👩🔬👨🔬
On my way to #eshg25!
If you are interested in the work we do at the FunGen lab, check out the flash talk on Sunday and poster on Monday by @lisahamerlinck.bsky.social or come and have a coffee with team members @michael-b-vaughan.bsky.social, @eedhaene.bsky.social or me. Hope to see you there!
If you are interested in the work we do at the FunGen lab, check out the flash talk on Sunday and poster on Monday by @lisahamerlinck.bsky.social or come and have a coffee with team members @michael-b-vaughan.bsky.social, @eedhaene.bsky.social or me. Hope to see you there!
May 24, 2025 at 8:34 AM
On my way to #eshg25!
If you are interested in the work we do at the FunGen lab, check out the flash talk on Sunday and poster on Monday by @lisahamerlinck.bsky.social or come and have a coffee with team members @michael-b-vaughan.bsky.social, @eedhaene.bsky.social or me. Hope to see you there!
If you are interested in the work we do at the FunGen lab, check out the flash talk on Sunday and poster on Monday by @lisahamerlinck.bsky.social or come and have a coffee with team members @michael-b-vaughan.bsky.social, @eedhaene.bsky.social or me. Hope to see you there!
📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline: June 23
Link: www.ugent.be/en/work/scie...
Link: www.ugent.be/en/work/scie...
Postdoctoral fellow
www.ugent.be
May 22, 2025 at 7:26 PM
📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline: June 23
Link: www.ugent.be/en/work/scie...
Link: www.ugent.be/en/work/scie...
Reposted by Sarah Vergult
Really enjoying Neurogenomics25 @humantechnopole.bsky.social Excellent space, excellent talks, excellent coffee!
I'll be sharing some of our research ( @svergult.bsky.social ) on the ability of Clinically Accessible Tissues to accurately reflect neuronal gene regulation ( poster #66) #neurogen25
I'll be sharing some of our research ( @svergult.bsky.social ) on the ability of Clinically Accessible Tissues to accurately reflect neuronal gene regulation ( poster #66) #neurogen25
May 19, 2025 at 1:50 PM
Really enjoying Neurogenomics25 @humantechnopole.bsky.social Excellent space, excellent talks, excellent coffee!
I'll be sharing some of our research ( @svergult.bsky.social ) on the ability of Clinically Accessible Tissues to accurately reflect neuronal gene regulation ( poster #66) #neurogen25
I'll be sharing some of our research ( @svergult.bsky.social ) on the ability of Clinically Accessible Tissues to accurately reflect neuronal gene regulation ( poster #66) #neurogen25
If you are at the Neurogenomics conference in Milan, go and check out the posters of @eedhaene.bsky.social and @michael-b-vaughan.bsky.social. #neurogen25
Looking forward to exciting science and to connect with colleagues in Milan at the Neurogenomics conference @humantechnopole.bsky.social Presenting our research ( @svergult.bsky.social @lisahamerlinck.bsky.social ) on noncoding variants in the FOXG1 locus during the poster session (#88) #neurogen25
May 19, 2025 at 10:46 AM
If you are at the Neurogenomics conference in Milan, go and check out the posters of @eedhaene.bsky.social and @michael-b-vaughan.bsky.social. #neurogen25
Paper Alert!! Last year we reported on ZFHX3 loss of function (LoF), today we report that also ZFHX4 LoF is associated with an NDD. Great collaboration the ZFHX4 consortium, excellently led by María del Rocío Perez Baca and María Palomares. As always great collab with co-supervisor Bert Callewaert.
📣New from @svergult.bsky.social & co
📄Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder
📄Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder
Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder
We associate ZFHX4 loss of function with syndromic intellectual disability. While
ZFHX4 deletions showed a mild methylation profile, protein-truncating variants did
not. Multi-omics data implicate ZFH...
www.cell.com
May 13, 2025 at 7:11 PM
Paper Alert!! Last year we reported on ZFHX3 loss of function (LoF), today we report that also ZFHX4 LoF is associated with an NDD. Great collaboration the ZFHX4 consortium, excellently led by María del Rocío Perez Baca and María Palomares. As always great collab with co-supervisor Bert Callewaert.
Reposted by Sarah Vergult
Final talk of this year's #GRD25 conference, also selected from submitted abstracts, is Eva D'haene from Ghent University talking about "Non-coding structural variants disrupt a critical regulatory region steering FOXG1 transcription during early neurodevelopment"
April 11, 2025 at 11:52 AM
Final talk of this year's #GRD25 conference, also selected from submitted abstracts, is Eva D'haene from Ghent University talking about "Non-coding structural variants disrupt a critical regulatory region steering FOXG1 transcription during early neurodevelopment"
📣 New preprint from the FunGen lab, see below 👇👇👇! This research was led by two incredible ladies in my lab, postdoctoral researcher @eedhaene.bsky.social and PhD student Lisa Hamerlinck. Nice to see how a team effort of years finally came together. If you want to know more, read Eva's 🧵 below.
📢 New preprint from the FunGen lab @svergult.bsky.social on how non-coding structural variants disrupt FOXG1 regulation during early neurodevelopment. Great teamwork from Lisa Hamerlinck and everyone in the lab! Thread below👇
www.medrxiv.org/content/10.1...
#GeneRegulation #RareDisease #Epigenomics
www.medrxiv.org/content/10.1...
#GeneRegulation #RareDisease #Epigenomics
March 13, 2025 at 5:27 PM
📣 New preprint from the FunGen lab, see below 👇👇👇! This research was led by two incredible ladies in my lab, postdoctoral researcher @eedhaene.bsky.social and PhD student Lisa Hamerlinck. Nice to see how a team effort of years finally came together. If you want to know more, read Eva's 🧵 below.
Today is #rarediseaseday2025
Rare diseases are rare, but there are many people living with a rare disease.
By brighten up our workplace with shades of pink, blue, green, and purple 🩷💙💚💜 we, the FunGen team, want to help raising visibility for rare diseases.
#ShareYourColours
Rare diseases are rare, but there are many people living with a rare disease.
By brighten up our workplace with shades of pink, blue, green, and purple 🩷💙💚💜 we, the FunGen team, want to help raising visibility for rare diseases.
#ShareYourColours
February 28, 2025 at 8:51 PM
Today is #rarediseaseday2025
Rare diseases are rare, but there are many people living with a rare disease.
By brighten up our workplace with shades of pink, blue, green, and purple 🩷💙💚💜 we, the FunGen team, want to help raising visibility for rare diseases.
#ShareYourColours
Rare diseases are rare, but there are many people living with a rare disease.
By brighten up our workplace with shades of pink, blue, green, and purple 🩷💙💚💜 we, the FunGen team, want to help raising visibility for rare diseases.
#ShareYourColours
To all great women in science: Happy #WomenInScienceDay! Glad to have met many great female scientists and hope to meet many more 🥰!
Marie Sklodowska Curie was the first woman to receive a #NobelPrize and the first person to receive the honor twice.
In 2017, #ScienceBooks explored the dynamics that established Curie as “the most iconic of all female scientists.” #WomenInScienceDay
In 2017, #ScienceBooks explored the dynamics that established Curie as “the most iconic of all female scientists.” #WomenInScienceDay
The making and remaking of Marie Curie
The famous physicist's legacy looms large 150 years after her birth
scim.ag
February 11, 2025 at 8:48 PM
To all great women in science: Happy #WomenInScienceDay! Glad to have met many great female scientists and hope to meet many more 🥰!
Reposted by Sarah Vergult
Prof Joe Marsh and I have a PhD project as part of the 2025 Edinburgh Doctoral College Scholarship: "Integrating AI, Biophysical Modelling and Experimental Validation for Enhancer Variant Interpretation". Closing date for applications is 25 April 2025. Please get in touch if you are interested! 🧬🧠
Edinburgh Doctoral College Scholarship
Applications now open for 2025 intake
institute-genetics-cancer.ed.ac.uk
February 9, 2025 at 11:13 AM
Prof Joe Marsh and I have a PhD project as part of the 2025 Edinburgh Doctoral College Scholarship: "Integrating AI, Biophysical Modelling and Experimental Validation for Enhancer Variant Interpretation". Closing date for applications is 25 April 2025. Please get in touch if you are interested! 🧬🧠
Reposted by Sarah Vergult
Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...
www.science.org
January 31, 2025 at 7:41 PM
Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
As always, great meeting!! 👇🏻👇🏻
Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21).
Book the dates and register soon!!!
meetings.embo.org/event/25-enh...
Book the dates and register soon!!!
meetings.embo.org/event/25-enh...
Enhancer Mechanics and Enhanceropathies
Join us for the highly anticipated third EMBO workshop on Enhancer Mechanics and Enhanceropathies! Building on the success of our previous meetings in Santander (2021) and Marseilles (2023), this eve…
meetings.embo.org
January 31, 2025 at 9:19 PM
As always, great meeting!! 👇🏻👇🏻
Reposted by Sarah Vergult
I want to provide an overview and perspective of rare disease genomic testing, which is a real success story of science impacting health - a science which goes back over 100 years and yet is still striding forward and much more to come.
December 19, 2024 at 12:56 PM
I want to provide an overview and perspective of rare disease genomic testing, which is a real success story of science impacting health - a science which goes back over 100 years and yet is still striding forward and much more to come.
Christmas lunch @FunGenLab 👉🏻 Combining what we love the most: Great food 🍜 and discussing great science 🧠! A big shout out to our master students for their excellent presentations 👏🏻, well done!
December 18, 2024 at 9:03 PM
Christmas lunch @FunGenLab 👉🏻 Combining what we love the most: Great food 🍜 and discussing great science 🧠! A big shout out to our master students for their excellent presentations 👏🏻, well done!