In the JAKPPPOT 🎰 trial lead by David Gleason, historical placebo data from the APRICOT trial will be used as an external control arm to explore a signal of effect size. The protocol for this mixed-methods feasibility trial is now available #BMJOpen
bmjopen.bmj.com/content/15/8...

Are estimands being correctly used?
A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here:
trialsjournal.biomedcentral.com/articles/10.... #Trials

How can we implement reference-based multiple imputation to handle #MissingData in #ClinicalTrials for longitudinal binary outcomes?
We explored 2 different approaches. Find out which performed best here: onlinelibrary.wiley.com/doi/10.1002/...

Do mince pies or carrots improve reindeer performance?🥕🥧How can #Estimands help to ensure #Trials answers the question of interest -despite reindeer shenanigans 🦌? Estimands explained this #Christmas in trialsjournal.biomedcentral.com/articles/10....
#AcademicSky #StatsSky #EpiSky #MedSky #SciComm

🥕🥧 Carrots or Mince pie: what fuels Santa's reindeer best? Find out & understand the importance of #estimands to clearly specify trial research questions in ✨All I want for Christmas…is a precisely defined research question✨🎅
shorturl.at/qMB6Y #Trials
#AcademicSky #StatsSky #EpiSky #MedSky #SciComm

📅SAVE THE DATE(s) & spread the word about the ***2nd Contemporary Clinical Trials Methodology Meeting*** from ICTU & NIHR RSS Imperial and partners hub, 2nd & 3rd April 2025. Register interest here: bit.ly/3Zg7yUn More details with booking link coming soon!