Susan Lee
@susanleeo.bsky.social
Reader, not big commentor. Politics junkie. My likes are my bookmarks.
Reposted by Susan Lee
🌱 From Frontiers in Horticulture: Basil grown in aquaponics performed well with moderate walnut or pistachio shell substrates, showing these local by-products can replace part of coconut coir in sustainable media. (Alharith Alghaithy, Irwin R. Donis-Gonzalez)
▶️ www.frontiersin.org/journals/hor...
▶️ www.frontiersin.org/journals/hor...
Frontiers | Suitability of walnut and pistachio shells as soilless substrates for producing Genovese basil in aquaponic systems
IntroductionThe use of agricultural by-products, such as walnut and pistachio shells, is emerging as a sustainable substrate alternative to conventional subs...
www.frontiersin.org
November 19, 2025 at 5:23 PM
🌱 From Frontiers in Horticulture: Basil grown in aquaponics performed well with moderate walnut or pistachio shell substrates, showing these local by-products can replace part of coconut coir in sustainable media. (Alharith Alghaithy, Irwin R. Donis-Gonzalez)
▶️ www.frontiersin.org/journals/hor...
▶️ www.frontiersin.org/journals/hor...
Reposted by Susan Lee
Reposted by Susan Lee
Trastuzumab deruxtecan slashes mortality in HER2-low metastatic breast cancer, establishing it as the new standard post-chemotherapy.
by Modi S, Jacot W (...) Cameron D et 22 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
by Modi S, Jacot W (...) Cameron D et 22 al. in Nat Med #MedSky
👉 get more here
📖 read the article:
Trastuzumab deruxtecan in HER2-low metastatic breast cancer: long-term survival analysis of the randomized, phase 3 DESTINY-Breast04 trial - Nature Medicine
This prespecified updated survival and exploratory subgroup efficacy analysis of the phase 3 DESTINY-Breast04 trial shows that trastuzumab deruxtecan treatment in patients with HER2-low metastatic breast cancer leads to continuous survival benefit irrespective of estrogen receptor or hormone receptor status.
www.nature.com
October 17, 2025 at 12:57 PM
Reposted by Susan Lee
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
September 25, 2025 at 8:13 PM
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
Reposted by Susan Lee
The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
September 24, 2025 at 10:38 PM
The projected rise in global cancer deaths
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
1990 —5.9 million
2023—10.4 million
2050—18.8 million
is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
Reposted by Susan Lee
The path to preventing rheumatoid arthritis
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.
www.science.org
September 24, 2025 at 6:47 PM
The path to preventing rheumatoid arthritis
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
Reposted by Susan Lee
Reposted by Susan Lee
A simple way to help reduce obesity and stroke?
Stop the shifts in our clocks twice a year
www.pnas.org/doi/abs/10.1...
Stop the shifts in our clocks twice a year
www.pnas.org/doi/abs/10.1...
Circadian-informed modeling predicts regional variation in obesity and stroke outcomes under different permanent US time policies | PNAS
Seasonal changes in time policy, such as switching between Standard Time (SDT) and
Daylight Saving Time (DST), have been adopted by many countries,...
www.pnas.org
September 15, 2025 at 8:32 PM
A simple way to help reduce obesity and stroke?
Stop the shifts in our clocks twice a year
www.pnas.org/doi/abs/10.1...
Stop the shifts in our clocks twice a year
www.pnas.org/doi/abs/10.1...
Reposted by Susan Lee
Ikmen book 27 The Wooden Library published in paperback on 11th September. I’m giving away 2 copies to celebrate. RT and follow to enter. Winners announced Wednesday 10 September.
September 3, 2025 at 11:36 AM
Ikmen book 27 The Wooden Library published in paperback on 11th September. I’m giving away 2 copies to celebrate. RT and follow to enter. Winners announced Wednesday 10 September.
Reposted by Susan Lee
One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth
nature.com/articles/s43...
nature.com/articles/s43...
Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic - Nature Cancer
Cancer-associated fibroblasts represent a functionally diverse and heterogeneous entity within the solid tumor microenvironment. Mitochondrial transfer from cancer cells to fibroblasts is now shown to...
nature.com
August 28, 2025 at 4:10 PM
One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth
nature.com/articles/s43...
nature.com/articles/s43...
Reposted by Susan Lee
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
nature.com/articles/s41...
Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial - Nature Medicine
In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and...
nature.com
August 27, 2025 at 3:06 PM
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Susan Lee
How does Epstein- Barr virus induce multiple sclerosis?
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
www.nature.com
August 6, 2025 at 3:24 PM
How does Epstein- Barr virus induce multiple sclerosis?
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
Reposted by Susan Lee
New @nature.com
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.
nature.com
August 6, 2025 at 3:16 PM
New @nature.com
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
Reposted by Susan Lee
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 4, 2025 at 11:38 PM
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Reposted by Susan Lee
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
August 4, 2025 at 9:09 PM
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
erictopol.substack.com/p/our-braini...
Reposted by Susan Lee
Reposted by Susan Lee
Dendritic copolymer-drug conjugates dramatically improved triple-negative breast cancer treatment, achieving 95% tumor suppression with reduced side effects.
by Liu G, Wang B (...) Luo K et 4 al. in Acta Biomater #MedSky
👉 get more here
📖 read the article:
by Liu G, Wang B (...) Luo K et 4 al. in Acta Biomater #MedSky
👉 get more here
📖 read the article:
Redox-responsive dendritic copolymer-drug conjugates enhance therapeutic mitophagy through coordinated microtubule destabilization for synergistic triple-negative breast cancer therapy
Application of microtubule-targeting agents (MTAs) for triple-negative breast cancer (TNBC) is hampered by their limited efficacy and strong systemic …
www.sciencedirect.com
July 1, 2025 at 2:34 AM
Reposted by Susan Lee
A single CD137 antibody-drug conjugate dose effectively prevents acute GVHD in primates, paving the way for new transplant therapies.
by Gerdemann U, Kimler K (...) Tkachev V et 22 al. in Blood #MedSky
👉 get more here
📖 read the article:
by Gerdemann U, Kimler K (...) Tkachev V et 22 al. in Blood #MedSky
👉 get more here
📖 read the article:
A single dose of a CD137 antibody-drug conjugate protects nonhuman primate allogeneic HCT recipients against acute GVHD
Key Points. In NHPs, a single CD137-ADC dose post-HCT eliminates PD-1+ effector T-cells, enabling reconstitution of non-pathogenic T-cell subsets.The CD137
ashpublications.org
June 21, 2025 at 2:17 AM
Reposted by Susan Lee
How microplastics can induce a leaky gut
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 10, 2025 at 3:52 PM
How microplastics can induce a leaky gut
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Susan Lee
Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease
www.nature.com/articles/s43...
www.nature.com/articles/s43...
June 2, 2025 at 1:05 PM
Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Wow. I read anecdotes in early Jan that suggested if we wanted this vaccine we should get it ASAP. I did. Novavax. I cannot believe this terrible idea is hatched.
BREAKING: FDA says covid boosters now only for those over 65 or with preconditions. www.statnews.com/2025/05/20/f...
FDA will limit Covid vaccines to people over 65 or at high risk of serious illness, leaders say
The FDA announced it will limit access to Covid-19 vaccines going forward to people 65 and older and others at high risk of serious illness
www.statnews.com
May 20, 2025 at 10:39 PM
Wow. I read anecdotes in early Jan that suggested if we wanted this vaccine we should get it ASAP. I did. Novavax. I cannot believe this terrible idea is hatched.
Reposted by Susan Lee
BioPharmCatalyst Weekly #Watchlist
Key Catalysts Due Near Term
$KROS $PYPD $VERA $NKTR $LYRA $BHVN $TOVX $MLYS $ASND $ACTU $PBM
www.biopharmcatalyst.com/news/2025/ke...
Key Catalysts Due Near Term
$KROS $PYPD $VERA $NKTR $LYRA $BHVN $TOVX $MLYS $ASND $ACTU $PBM
www.biopharmcatalyst.com/news/2025/ke...
April 25, 2025 at 9:06 PM
BioPharmCatalyst Weekly #Watchlist
Key Catalysts Due Near Term
$KROS $PYPD $VERA $NKTR $LYRA $BHVN $TOVX $MLYS $ASND $ACTU $PBM
www.biopharmcatalyst.com/news/2025/ke...
Key Catalysts Due Near Term
$KROS $PYPD $VERA $NKTR $LYRA $BHVN $TOVX $MLYS $ASND $ACTU $PBM
www.biopharmcatalyst.com/news/2025/ke...
Reposted by Susan Lee
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
www.nejm.org
April 23, 2025 at 10:22 PM
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Susan Lee
GLP-1RA and SGLT2i Medications may have protective effects against the development of Alzheimer’s disease and related dementias in patients with Type 2 diabetes.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
GLP-1RAs and SGLT2is for Type 2 Diabetes and Alzheimer Disease
This population-based cohort study examines the association of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors with the risk of Alzheimer disease and related de...
jamanetwork.com
April 17, 2025 at 1:14 AM
GLP-1RA and SGLT2i Medications may have protective effects against the development of Alzheimer’s disease and related dementias in patients with Type 2 diabetes.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...