Sudheer Peneti Ph.D
@sudheerpeneti.bsky.social
Postdoctoral researcher| Pasteur Institute, Paris. Exploring how cells move and adapt in complex environments.
PhD|Institute Jacques Monod, Paris. Passionate about ECM mechanics, Intermediate filaments, and cell migration.
PhD|Institute Jacques Monod, Paris. Passionate about ECM mechanics, Intermediate filaments, and cell migration.
Reposted by Sudheer Peneti Ph.D
Interesting work here…
☕Vanni et al. show a role for #microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and degradation, leading to YAP/TAZ activation. #mechanobiology #cytoskeleton
bit.ly/4oS2Ju3
bit.ly/4oS2Ju3
Microtubule architecture connects AMOT stability to YAP/TAZ mechanotransduction and Hippo signalling - Nature Cell Biology
Vanni et al. show a role for microtubules in YAP/TAZ mechanosignalling. Mechanoresponsive microtubule reorganization into centrosomal arrays allows for AMOT delivery to pericentrosomal proteasomes and...
bit.ly
November 4, 2025 at 10:52 PM
Interesting work here…
Reposted by Sudheer Peneti Ph.D
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions | Science Advances www.science.org/doi/10.1126/...
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions
Excess area of the nuclear lamina, observed as wrinkles in a round nucleus, enables cell migration through constricting channels.
www.science.org
October 24, 2025 at 9:09 AM
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions | Science Advances www.science.org/doi/10.1126/...
Reposted by Sudheer Peneti Ph.D
How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv!
www.biorxiv.org/content/10.1...
See the thread 🧵 below for more information.
www.biorxiv.org/content/10.1...
See the thread 🧵 below for more information.
Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells can dynamic...
www.biorxiv.org
October 5, 2025 at 3:11 PM
How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv!
www.biorxiv.org/content/10.1...
See the thread 🧵 below for more information.
www.biorxiv.org/content/10.1...
See the thread 🧵 below for more information.
Reposted by Sudheer Peneti Ph.D
Perspective @jcb.org by Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
October 15, 2025 at 4:00 PM
Perspective @jcb.org by Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Reposted by Sudheer Peneti Ph.D
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
www.rockefeller.edu/news/38446-h...
How cells move and change shape—and why it matters for our health - News
Inside each of your cells, there’s a microscopic scaffolding that helps determine what the cell looks like, how it moves, and how it responds to its surroundings. This internal structure, called the c...
www.rockefeller.edu
October 9, 2025 at 11:54 AM
How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding.
www.rockefeller.edu/news/38446-h...
www.rockefeller.edu/news/38446-h...
Reposted by Sudheer Peneti Ph.D
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...
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doi.org/10.1101/2025...
October 8, 2025 at 1:05 PM
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...
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doi.org/10.1101/2025...
Reposted by Sudheer Peneti Ph.D
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids
Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.
journals.biologists.com
October 3, 2025 at 9:54 AM
Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids
journals.biologists.com/dev/article/...
Reposted by Sudheer Peneti Ph.D
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 1, 2025 at 6:08 PM
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Sudheer Peneti Ph.D
📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
September 19, 2025 at 6:25 PM
📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...
Reposted by Sudheer Peneti Ph.D
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Regulation of epithelial tissue homeostasis by active trans-epithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
www.biorxiv.org
September 17, 2025 at 2:46 PM
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Reposted by Sudheer Peneti Ph.D
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
September 15, 2025 at 2:12 AM
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
Reposted by Sudheer Peneti Ph.D
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
September 9, 2025 at 8:01 PM
1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
Reposted by Sudheer Peneti Ph.D
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
September 9, 2025 at 4:05 PM
Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.
doi.org/10.1101/2025...
Reposted by Sudheer Peneti Ph.D
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology
How epithelial junctions mature: Study shows conformational transition in key protein
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...
www.uni-muenster.de
September 8, 2025 at 1:24 PM
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology
Reposted by Sudheer Peneti Ph.D
Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The complex microscopic dynamics of cells in high-density epithelial tissues
Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...
www.biorxiv.org
September 10, 2025 at 10:14 AM
Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sudheer Peneti Ph.D
For #zebrafish people - we have a joint @ZDMSociety @InfoIzfs webinar focused on single-cell tech coming up on February 20th. Featuring Yinan Wan, Jialin Liu and Loic Royer. Register here: www.izfs.org/education/we...
February 10, 2025 at 10:20 AM
For #zebrafish people - we have a joint @ZDMSociety @InfoIzfs webinar focused on single-cell tech coming up on February 20th. Featuring Yinan Wan, Jialin Liu and Loic Royer. Register here: www.izfs.org/education/we...
Reposted by Sudheer Peneti Ph.D
Epithelial tension controls intestinal cell extrusion | Science www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
September 4, 2025 at 8:03 PM
Epithelial tension controls intestinal cell extrusion | Science www.science.org/doi/10.1126/...
Reposted by Sudheer Peneti Ph.D
Beautiful story that combined mechanobiology, evolution, and the power of fly (opto)genetics to make sense of the cephalic furrow. It was a pleasure writing the News & Views. No doubt this is still just the beginning for the field of mechano-evo-devo! Hats off to all involved
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 8:48 AM
Beautiful story that combined mechanobiology, evolution, and the power of fly (opto)genetics to make sense of the cephalic furrow. It was a pleasure writing the News & Views. No doubt this is still just the beginning for the field of mechano-evo-devo! Hats off to all involved
Reposted by Sudheer Peneti Ph.D
Tsai, T. Y. C., Garner, R. M., & Megason, S. G. (2022). Adhesion-based self-organization in tissue patterning. Annual review of cell and developmental biology, #EpithelialMechanicsReview www.annualreviews.org/content/jour...
August 28, 2025 at 12:01 PM
Tsai, T. Y. C., Garner, R. M., & Megason, S. G. (2022). Adhesion-based self-organization in tissue patterning. Annual review of cell and developmental biology, #EpithelialMechanicsReview www.annualreviews.org/content/jour...
Reposted by Sudheer Peneti Ph.D
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
August 28, 2025 at 4:18 AM
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Sudheer Peneti Ph.D
Always nice to see the field moving forward! Paper out from the White lab in @nature.com today! www.nature.com/articles/s41.... #Microtubules conferring #mechanical resistance to compression in melanoma cells > similar to our findings in @natcellbio.nature.com doi.org/10.1038/s415... ☝️
August 28, 2025 at 12:00 AM
Always nice to see the field moving forward! Paper out from the White lab in @nature.com today! www.nature.com/articles/s41.... #Microtubules conferring #mechanical resistance to compression in melanoma cells > similar to our findings in @natcellbio.nature.com doi.org/10.1038/s415... ☝️
Reposted by Sudheer Peneti Ph.D
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr
For more information, please contact: marie-helene.verlhac@college-de-france.fr
August 28, 2025 at 8:23 AM
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: marie-helene.verlhac@college-de-france.fr
For more information, please contact: marie-helene.verlhac@college-de-france.fr
Reposted by Sudheer Peneti Ph.D
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
March 31, 2025 at 1:11 PM
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
Reposted by Sudheer Peneti Ph.D
Luciano, M., Tomba, C., Roux, A., & Gabriele, S. (2024). How multiscale curvature couples forces to cellular functions. Nature Reviews Physics, #EpithelialMechanicsReview www.nature.com/articles/s42...
August 22, 2025 at 7:01 AM
Luciano, M., Tomba, C., Roux, A., & Gabriele, S. (2024). How multiscale curvature couples forces to cellular functions. Nature Reviews Physics, #EpithelialMechanicsReview www.nature.com/articles/s42...
Reposted by Sudheer Peneti Ph.D
Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳
Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻
Enjoy the reading www.nature.com/articles/s41...
Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻
Enjoy the reading www.nature.com/articles/s41...
The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics
Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...
www.nature.com
August 25, 2025 at 9:59 AM
Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳
Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻
Enjoy the reading www.nature.com/articles/s41...
Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻
Enjoy the reading www.nature.com/articles/s41...