Without BMP signalling, LME doesn’t converge to the dorsal side, the last part of the LME migration. Is BMP also needed to onset the tumbling motion? Yes! When we depleted BMP from the animal ectoderm, the ectoderm became cohesive, and LME migration no longer stopped.

We tested that by changing the animal's or lateral ectoderm's tissue cohesiveness before transplantation. We increased in the animal ectoderm and decreased in the lateral one, which was sufficient to inverse the effect on LME migration. What does modulate the cohesiveness of the ectoderm?

We noticed that the animal ectoderm thins faster than the lateral one, suggesting that the tissue properties differ. Specifically, we found that the animal ectoderm is loosened and less cohesive. Does the difference in cohesiveness regulate LME animal migration?

I hypothesized that the substrate could tell the LME when and where to stop the animal migration. We first found that the LME migrates on the ectoderm, which the epiboly causes to move passively in the opposite direction. Does the ectoderm cause the LME to start tumbling?

Without BMP signalling, LME doesn’t converge to the dorsal side, the last part of the LME migration. Is BMP also needed to the onset the tumbling motion? Yes! When we depleted BMP from the animal ectoderm, the ectoderm became cohesive, and LME migration no longer stopped.

We tested that by changing the animal's or lateral ectoderm's tissue cohesiveness before transplantation. We increased in the animal ectoderm and decreased in the lateral one, which was sufficient to inverse the effect on LME migration. What does modulate the cohesiveness of the ectoderm?

We noticed that the animal ectoderm thins faster than the lateral one, suggesting that the tissue properties differ. Specifically, we found that the animal ectoderm is loosened and less cohesive. Does the difference in cohesiveness regulate LME animal migration?

I hypothesized that the substrate could tell the LME when and where to stop the animal migration. We first found that the LME migrates on the ectoderm, which the epiboly causes to move passively in the opposite direction. Does the ectoderm cause the LME to start tumbling?