Stephen Lapinsky
@stephenlap.bsky.social
Critical Care
Obstetric Medicine
Pulmonary & Critical Care in pregnancy
Sinai Health System & University of Toronto
🇨🇦🇿🇦
Obstetric Medicine
Pulmonary & Critical Care in pregnancy
Sinai Health System & University of Toronto
🇨🇦🇿🇦
Mechanism of preeclampsia: fascinating talk @nasom-obmed.bsky.social 2025 by Dr. Surendra Sharma on the role of impaired autophagy related to tau protein aggregation, and treatable with trehalose
pubmed.ncbi.nlm.nih.gov/38760513/
pubmed.ncbi.nlm.nih.gov/38760513/
April 26, 2025 at 3:42 PM
Mechanism of preeclampsia: fascinating talk @nasom-obmed.bsky.social 2025 by Dr. Surendra Sharma on the role of impaired autophagy related to tau protein aggregation, and treatable with trehalose
pubmed.ncbi.nlm.nih.gov/38760513/
pubmed.ncbi.nlm.nih.gov/38760513/
Top 5 articles in OB Medicine in 2024 presented at @nasom-obmed.bsky.social 2025 meeting
April 26, 2025 at 3:39 PM
Top 5 articles in OB Medicine in 2024 presented at @nasom-obmed.bsky.social 2025 meeting
Jayson Potts opening the @nasom-obmed.bsky.social 2025 meeting in Newport, RI
April 25, 2025 at 8:16 PM
Jayson Potts opening the @nasom-obmed.bsky.social 2025 meeting in Newport, RI
New review on PlGF & sFlt1 in Obstetic care, by @sinaihealth.bsky.social leaders in the field.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
April 4, 2025 at 5:11 PM
New review on PlGF & sFlt1 in Obstetic care, by @sinaihealth.bsky.social leaders in the field.
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Time to register for NASOM 2025
April 25-26, Newport, Rhode Island
Or participate virtually!
Early bird rate ends March 31st
nasom.org/current-year...
April 25-26, Newport, Rhode Island
Or participate virtually!
Early bird rate ends March 31st
nasom.org/current-year...
March 17, 2025 at 12:23 PM
Time to register for NASOM 2025
April 25-26, Newport, Rhode Island
Or participate virtually!
Early bird rate ends March 31st
nasom.org/current-year...
April 25-26, Newport, Rhode Island
Or participate virtually!
Early bird rate ends March 31st
nasom.org/current-year...
Cystic fibrosis & pregnancy
New data from American Cystic Fibrosis Foundation Patient Registry.
Pregnancy assoc with:
- reduced hazard of death compared to never-pregnant
- no significant impact on lung function.
www.sciencedirect.com/science/arti...
New data from American Cystic Fibrosis Foundation Patient Registry.
Pregnancy assoc with:
- reduced hazard of death compared to never-pregnant
- no significant impact on lung function.
www.sciencedirect.com/science/arti...
February 24, 2025 at 4:09 PM
Cystic fibrosis & pregnancy
New data from American Cystic Fibrosis Foundation Patient Registry.
Pregnancy assoc with:
- reduced hazard of death compared to never-pregnant
- no significant impact on lung function.
www.sciencedirect.com/science/arti...
New data from American Cystic Fibrosis Foundation Patient Registry.
Pregnancy assoc with:
- reduced hazard of death compared to never-pregnant
- no significant impact on lung function.
www.sciencedirect.com/science/arti...
I never really thought much about where our fruit came from, but now that we buy non-American, these Italian & Israeli options are great! 🇨🇦
February 13, 2025 at 8:38 PM
I never really thought much about where our fruit came from, but now that we buy non-American, these Italian & Israeli options are great! 🇨🇦
External aortic compression in OB hemorrhage by Alvaro Nieto-Calvache. A simple maneuver to control bleeding and buy time
www.ajog.org/article/S000...
And video:
www.ajog.org/cms/10.1016/...
January 25, 2025 at 3:18 AM
External aortic compression in OB hemorrhage by Alvaro Nieto-Calvache. A simple maneuver to control bleeding and buy time
www.ajog.org/article/S000...
And video:
www.ajog.org/cms/10.1016/...
Early warning scores in maternal sepsis
Detailed evaluation of several EWS in a large WHO database of OB sepsis:
- OB & sepsis specific scores performed better
- none accurate enough for clinical use
- incomplete data is a problem
www.thelancet.com/journals/ecl...
Detailed evaluation of several EWS in a large WHO database of OB sepsis:
- OB & sepsis specific scores performed better
- none accurate enough for clinical use
- incomplete data is a problem
www.thelancet.com/journals/ecl...
January 17, 2025 at 6:01 PM
Early warning scores in maternal sepsis
Detailed evaluation of several EWS in a large WHO database of OB sepsis:
- OB & sepsis specific scores performed better
- none accurate enough for clinical use
- incomplete data is a problem
www.thelancet.com/journals/ecl...
Detailed evaluation of several EWS in a large WHO database of OB sepsis:
- OB & sepsis specific scores performed better
- none accurate enough for clinical use
- incomplete data is a problem
www.thelancet.com/journals/ecl...
Valuable new paper - rare but very difficult when you see it:
“Position statement on the diagnosis and management of acute leukaemia and aggressive lymphomas in pregnancy”
by an 🇦🇺 group including @slobsmedsyd.bsky.social
www.thelancet.com/journals/lan...
“Position statement on the diagnosis and management of acute leukaemia and aggressive lymphomas in pregnancy”
by an 🇦🇺 group including @slobsmedsyd.bsky.social
www.thelancet.com/journals/lan...
January 14, 2025 at 1:02 PM
Valuable new paper - rare but very difficult when you see it:
“Position statement on the diagnosis and management of acute leukaemia and aggressive lymphomas in pregnancy”
by an 🇦🇺 group including @slobsmedsyd.bsky.social
www.thelancet.com/journals/lan...
“Position statement on the diagnosis and management of acute leukaemia and aggressive lymphomas in pregnancy”
by an 🇦🇺 group including @slobsmedsyd.bsky.social
www.thelancet.com/journals/lan...
OB Medicine Conference abstracts now online in the journal
𝘖𝘣𝘴𝘵𝘦𝘵𝘳𝘪𝘤 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 (open access)!
MOMS 2024 (UK meeting):
journals.sagepub.com/doi/abs/10.1...
ISOM/SOMANZ 2024:
journals.sagepub.com/doi/full/10....
𝘖𝘣𝘴𝘵𝘦𝘵𝘳𝘪𝘤 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 (open access)!
MOMS 2024 (UK meeting):
journals.sagepub.com/doi/abs/10.1...
ISOM/SOMANZ 2024:
journals.sagepub.com/doi/full/10....
December 18, 2024 at 12:20 AM
OB Medicine Conference abstracts now online in the journal
𝘖𝘣𝘴𝘵𝘦𝘵𝘳𝘪𝘤 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 (open access)!
MOMS 2024 (UK meeting):
journals.sagepub.com/doi/abs/10.1...
ISOM/SOMANZ 2024:
journals.sagepub.com/doi/full/10....
𝘖𝘣𝘴𝘵𝘦𝘵𝘳𝘪𝘤 𝘔𝘦𝘥𝘪𝘤𝘪𝘯𝘦 (open access)!
MOMS 2024 (UK meeting):
journals.sagepub.com/doi/abs/10.1...
ISOM/SOMANZ 2024:
journals.sagepub.com/doi/full/10....
My first (1995?)
December 10, 2024 at 11:51 PM
My first (1995?)
Toronto traffic sunrise
December 7, 2024 at 3:20 PM
Toronto traffic sunrise
OK, I had to do one also (outside at 0 C)…
December 1, 2024 at 7:21 PM
OK, I had to do one also (outside at 0 C)…
Is this respiratory acidosis the same?
Limited data!
The acidosis may:
- right shift the fetal Hgb O₂ dissociation curve
- may adversely affect maternal & fetal hemodynamics
Limited data!
The acidosis may:
- right shift the fetal Hgb O₂ dissociation curve
- may adversely affect maternal & fetal hemodynamics
November 26, 2024 at 6:55 PM
Is this respiratory acidosis the same?
Limited data!
The acidosis may:
- right shift the fetal Hgb O₂ dissociation curve
- may adversely affect maternal & fetal hemodynamics
Limited data!
The acidosis may:
- right shift the fetal Hgb O₂ dissociation curve
- may adversely affect maternal & fetal hemodynamics
Animal studies are not conclusive, and also not applicable to the human situation, given the marked anatomical and physiological differences between human and animal placentas
November 24, 2024 at 3:10 PM
Animal studies are not conclusive, and also not applicable to the human situation, given the marked anatomical and physiological differences between human and animal placentas
Also, excess supplemental oxygen may reduce cardiac output (by increasing peripheral resistance) and result in a net decrease in oxygen delivery
November 24, 2024 at 3:07 PM
Also, excess supplemental oxygen may reduce cardiac output (by increasing peripheral resistance) and result in a net decrease in oxygen delivery
The fetus manages with very low PaO₂ levels as the fetal hemoglobin is left-shifted
November 24, 2024 at 3:05 PM
The fetus manages with very low PaO₂ levels as the fetal hemoglobin is left-shifted
Oxygen delivery to the fetus depends on (as for any organ):
- oxygen saturation
- hemoglobin
- blood flow
SaO₂ has the narrowest range of variation, much bigger changes occur in blood flow.
Blood flow likely much more important than small changes in SaO₂
- oxygen saturation
- hemoglobin
- blood flow
SaO₂ has the narrowest range of variation, much bigger changes occur in blood flow.
Blood flow likely much more important than small changes in SaO₂
November 24, 2024 at 3:03 PM
Oxygen delivery to the fetus depends on (as for any organ):
- oxygen saturation
- hemoglobin
- blood flow
SaO₂ has the narrowest range of variation, much bigger changes occur in blood flow.
Blood flow likely much more important than small changes in SaO₂
- oxygen saturation
- hemoglobin
- blood flow
SaO₂ has the narrowest range of variation, much bigger changes occur in blood flow.
Blood flow likely much more important than small changes in SaO₂
We often read and hear that oxygen saturation needs to be kept higher than the non-pregnant patient - is this true?
November 24, 2024 at 3:00 PM
We often read and hear that oxygen saturation needs to be kept higher than the non-pregnant patient - is this true?
Carolyn Calfee on subtypes/phenotypes in sepsis
November 17, 2024 at 7:08 PM
Carolyn Calfee on subtypes/phenotypes in sepsis
Critical Care Canada Forum 2024
(criticalcarecanada.com)
Fellows Day - currently Sepsis session, Manu Shankar-Hari speaking, to be followed by Carolyn Calfee
(criticalcarecanada.com)
Fellows Day - currently Sepsis session, Manu Shankar-Hari speaking, to be followed by Carolyn Calfee
November 17, 2024 at 6:51 PM
Critical Care Canada Forum 2024
(criticalcarecanada.com)
Fellows Day - currently Sepsis session, Manu Shankar-Hari speaking, to be followed by Carolyn Calfee
(criticalcarecanada.com)
Fellows Day - currently Sepsis session, Manu Shankar-Hari speaking, to be followed by Carolyn Calfee
Valuable messages from the 2024 MBRRACE report on maternal deaths in UK.
- causes of maternal mortality: PE, COVID, cardiac, mental health
- inequality plays a major role
- role for a national risk assessment tool
- causes of maternal mortality: PE, COVID, cardiac, mental health
- inequality plays a major role
- role for a national risk assessment tool
November 13, 2024 at 3:46 AM
Valuable messages from the 2024 MBRRACE report on maternal deaths in UK.
- causes of maternal mortality: PE, COVID, cardiac, mental health
- inequality plays a major role
- role for a national risk assessment tool
- causes of maternal mortality: PE, COVID, cardiac, mental health
- inequality plays a major role
- role for a national risk assessment tool
