Steffen Brünle
@steffenbruenle.bsky.social
Assistant Professor at Leiden University (NL) - GPCR Structural Biology / Drug Discovery - Single Particle Cryo-EM - Serial/Time-resolved X-ray Crystallography @ Synchrotrons/XFELs
Reposted by Steffen Brünle
🚀 Hey #GPCR community on #bluesky!
🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬
📅 Nov 12–14, 2025
This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR!
#GPCRforum #ScienceTogether
🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬
📅 Nov 12–14, 2025
This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR!
#GPCRforum #ScienceTogether
October 6, 2025 at 12:45 PM
🚀 Hey #GPCR community on #bluesky!
🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬
📅 Nov 12–14, 2025
This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR!
#GPCRforum #ScienceTogether
🌍 The 2nd GPCR Forum Virtual Conference is taking place!🧬
📅 Nov 12–14, 2025
This 3-day virtual event will bring together scientists and researchers from around the world to explore the latest breakthroughs in GPCR!
#GPCRforum #ScienceTogether
Reposted by Steffen Brünle
AlphaFold DB v6 is here! 🚀
Heads up on key updates:
🔹 Website now only serves v6
🔹 New URL format!!
🔹 Dual API active for 9 months (retirement: 25-06-2026)
Use the AlphaFold API for reliable access. Time to update those bookmarks & scripts!
Heads up on key updates:
🔹 Website now only serves v6
🔹 New URL format!!
🔹 Dual API active for 9 months (retirement: 25-06-2026)
Use the AlphaFold API for reliable access. Time to update those bookmarks & scripts!
📣Important update for #AlphaFold API users! New API fields launched on October 7th, 2025. We’ll maintain BOTH fields until June 25, 2026! Check the docs! 🔗
For more information, read the news item: www.ebi.ac.uk/pdbe/news/br...
For more information, read the news item: www.ebi.ac.uk/pdbe/news/br...
October 22, 2025 at 5:39 PM
AlphaFold DB v6 is here! 🚀
Heads up on key updates:
🔹 Website now only serves v6
🔹 New URL format!!
🔹 Dual API active for 9 months (retirement: 25-06-2026)
Use the AlphaFold API for reliable access. Time to update those bookmarks & scripts!
Heads up on key updates:
🔹 Website now only serves v6
🔹 New URL format!!
🔹 Dual API active for 9 months (retirement: 25-06-2026)
Use the AlphaFold API for reliable access. Time to update those bookmarks & scripts!
Reposted by Steffen Brünle
🚀 Introducing fully automated data processing for repeat-target #cryoEM.
Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.
Preprint: www.biorxiv.org/content/10.1...
Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.
Preprint: www.biorxiv.org/content/10.1...
October 20, 2025 at 2:32 PM
🚀 Introducing fully automated data processing for repeat-target #cryoEM.
Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.
Preprint: www.biorxiv.org/content/10.1...
Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.
Preprint: www.biorxiv.org/content/10.1...
It is my pleasure to invite you to the upcoming Kroese-Duijsters Symposium at Leiden University on 17th November. We have a great lineup of speakers covering time-resolved X-ray crystallography, time-resolved cryo-EM, microED, and AI approaches including a talk from DeepMind.
Are you interested in #StructuralBiology?
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel.
A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss.
www.universiteitleiden.nl/en/kroese-du...
Kroese-Duijsters Symposium 2025
The Kroese-Duijsters Symposia aim to provide researchers from different fields and different career stages to meet in an informal setting, to stimulate discussions and to start new collaborations. The...
www.universiteitleiden.nl
October 17, 2025 at 11:21 AM
It is my pleasure to invite you to the upcoming Kroese-Duijsters Symposium at Leiden University on 17th November. We have a great lineup of speakers covering time-resolved X-ray crystallography, time-resolved cryo-EM, microED, and AI approaches including a talk from DeepMind.
Very much looking forward visiting the Kostenis group at the University of Bonn over the next two days.
July 10, 2025 at 11:51 AM
Very much looking forward visiting the Kostenis group at the University of Bonn over the next two days.
Reposted by Steffen Brünle
Earlier this year, with Google DeepMind, we held the AlphaFold Education Summit to increase and strengthen global capacity through train-the-trainer sessions & the co-development of further #AlphaFold training.
Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat...
🧪🖥️🧬
Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat...
🧪🖥️🧬
May 29, 2025 at 2:11 PM
Earlier this year, with Google DeepMind, we held the AlphaFold Education Summit to increase and strengthen global capacity through train-the-trainer sessions & the co-development of further #AlphaFold training.
Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat...
🧪🖥️🧬
Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat...
🧪🖥️🧬
Today I am looking forward to the Oncode Accelerator Annual Event where I give the talk „Accelerated Structure-Based Drug Discovery: How Cryo-EM unlocks Molecular Mechanisms“.
May 21, 2025 at 8:20 AM
Today I am looking forward to the Oncode Accelerator Annual Event where I give the talk „Accelerated Structure-Based Drug Discovery: How Cryo-EM unlocks Molecular Mechanisms“.
Had a great time at the first @sbgrid.bsky.social workshop in Europe last week at Amazon Barcelona. Great people, good food and I learned a lot about using AWS for Cryo-EM data processing.
May 21, 2025 at 8:00 AM
Had a great time at the first @sbgrid.bsky.social workshop in Europe last week at Amazon Barcelona. Great people, good food and I learned a lot about using AWS for Cryo-EM data processing.
Happy to join bluesky.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
January 17, 2025 at 3:19 PM
Happy to join bluesky.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.