Siddhartha Mitra
@ssmitra.bsky.social
Macrophage aficionade | My lab studies CNS #immune cells in Adult and pediatric malignant #braintumors. We research novel #immunotherapy modalities to treat childhood #tumors | Lover of Historical Roman Military Fiction | Perpetual annoyance to my children
Excited to announce our latest manuscript!
burning question: do macrophages feel the same after “eating” a tumor cell as we do after a bean burrito vs. a kale salad? macrophages are reprogrammed by what they ingest.
jitc.bmj.com/content/13/9...
burning question: do macrophages feel the same after “eating” a tumor cell as we do after a bean burrito vs. a kale salad? macrophages are reprogrammed by what they ingest.
jitc.bmj.com/content/13/9...
Differential phagocytosis induces diverse macrophage activation states in malignant gliomas
Background Diffuse midline glioma (DMG) and glioblastoma (GBM) are aggressive brain tumors with limited treatment options. Macrophage phagocytosis is a complex, tightly regulated process governed by c...
jitc.bmj.com
September 6, 2025 at 4:37 PM
Excited to announce our latest manuscript!
burning question: do macrophages feel the same after “eating” a tumor cell as we do after a bean burrito vs. a kale salad? macrophages are reprogrammed by what they ingest.
jitc.bmj.com/content/13/9...
burning question: do macrophages feel the same after “eating” a tumor cell as we do after a bean burrito vs. a kale salad? macrophages are reprogrammed by what they ingest.
jitc.bmj.com/content/13/9...
Finally a Mitra/Hankinson lab outing. Fully rebuilt after COVID. Celebrating birthdays and just each other
March 8, 2025 at 1:03 AM
Finally a Mitra/Hankinson lab outing. Fully rebuilt after COVID. Celebrating birthdays and just each other
An absolutely phenomenal paper: Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 27, 2025 at 7:00 PM
An absolutely phenomenal paper: Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Siddhartha Mitra
Hope I'm the first to post this all time classic on this platform
November 19, 2024 at 4:51 AM
Hope I'm the first to post this all time classic on this platform
Reposted by Siddhartha Mitra
Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns
www.fiercebiotech.com/research/rep...
www.fiercebiotech.com/research/rep...
Report: Every dollar of NIH research funding doubles in economic returns
Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an
www.fiercebiotech.com
November 17, 2024 at 1:05 PM
Terrific piece summarizing a recent report: Every dollar of NIH research funding doubles in economic returns
www.fiercebiotech.com/research/rep...
www.fiercebiotech.com/research/rep...