Susan Shao
@sshaolab.bsky.social
Dissecting molecular mechanisms that regulate protein and cellular homeostasis. https://shao.hms.harvard.edu
...which nicely complement prohibitin structural work from the Guo and Gao labs! www.biorxiv.org/content/10.1...
Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease
Mitochondrial function critically dependents on protein quality control systems, with the m -AAA protease plays a key role at the inner mitochondrial membrane (IMM). The evolutionarily conserved prohi...
www.biorxiv.org
April 23, 2025 at 1:29 PM
...which nicely complement prohibitin structural work from the Guo and Gao labs! www.biorxiv.org/content/10.1...
ARMC1 assembles into a complex with MIRO that antagonizes retrograde mitochondrial movement. In another complex, ARMC1 associates with DNAJC11, which promotes ARMC1 removal from the mitochondrial surface. This balanced partitioning is important for steady-state mitochondrial distribution.
April 10, 2025 at 2:49 PM
ARMC1 assembles into a complex with MIRO that antagonizes retrograde mitochondrial movement. In another complex, ARMC1 associates with DNAJC11, which promotes ARMC1 removal from the mitochondrial surface. This balanced partitioning is important for steady-state mitochondrial distribution.
We find that the assembly/abundance control of a complex containing the mitochondrial trafficking adaptor MIRO depends on the spatial partitioning of the ARMC1 protein between the cytosol and distinct mitochondrial complexes.
April 10, 2025 at 2:49 PM
We find that the assembly/abundance control of a complex containing the mitochondrial trafficking adaptor MIRO depends on the spatial partitioning of the ARMC1 protein between the cytosol and distinct mitochondrial complexes.
