Shailaja Seetharaman
@sseethar.bsky.social
Incoming Assistant Prof @MBISg, NUS | Interested in mechanobiology | Postdoc, Gardel Lab @UChicago | Schmidt AI in Science and AHA Postdoc | Previously Marie Curie and FRM PhD, Etienne-Manneville Lab @Institut Pasteur
Pinned
Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @mbisg.bsky.social, and the Dept of Physiology at @nusingapore.bsky.social in the fall! More about our work on vascular mechanobiology in health & disease mechano-medicine-lab.com
Reposted by Shailaja Seetharaman
Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553
October 15, 2025 at 1:46 PM
Almost 40 years later, has anyone identified what "buttonin", the 75-kD protein that decorates microtubule like buttons, is? dx.doi.org/10.1083/jcb.104.6.1553
Reposted by Shailaja Seetharaman
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
October 16, 2025 at 9:55 PM
1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social :
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
"Self-organization of tumor heterogeneity and plasticity"
biorxiv.org/content/10.1...
Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated?
A thread👇
Reposted by Shailaja Seetharaman
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Reposted by Shailaja Seetharaman
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
August 15, 2025 at 10:50 AM
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
Reposted by Shailaja Seetharaman
Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis
pubs.aip.org/aip/apb/arti...
pubs.aip.org/aip/apb/arti...
Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis
Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from t
pubs.aip.org
June 18, 2025 at 10:34 PM
Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis
pubs.aip.org/aip/apb/arti...
pubs.aip.org/aip/apb/arti...
Reposted by Shailaja Seetharaman
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
rdcu.be
August 7, 2025 at 7:27 AM
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Reposted by Shailaja Seetharaman
Congratulations to Thomas Callister, Peter Lu (@petery.lu), Aditya Nandy, Ludwig Schneider, Shailaja Seetharaman (@sseethar.bsky.social), Colm Talbot, Madeleine Torcasso, and Yihang Wang!
Congratulations to Outgoing Eric and Wendy Schmidt AI in Science Fellows – DSI
datascience.uchicago.edu
July 30, 2025 at 9:12 PM
Congratulations to Thomas Callister, Peter Lu (@petery.lu), Aditya Nandy, Ludwig Schneider, Shailaja Seetharaman (@sseethar.bsky.social), Colm Talbot, Madeleine Torcasso, and Yihang Wang!
Reposted by Shailaja Seetharaman
Final presentations for Physiology 2025 were last weekend; the students did an awesome job. @sseethar.bsky.social, @andyletzhang.bsky.social, @squishycell.bsky.social, and I were all very proud 🤩.
July 31, 2025 at 1:33 AM
Final presentations for Physiology 2025 were last weekend; the students did an awesome job. @sseethar.bsky.social, @andyletzhang.bsky.social, @squishycell.bsky.social, and I were all very proud 🤩.
Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @mbisg.bsky.social, and the Dept of Physiology at @nusingapore.bsky.social in the fall! More about our work on vascular mechanobiology in health & disease mechano-medicine-lab.com
July 9, 2025 at 5:00 PM
Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @mbisg.bsky.social, and the Dept of Physiology at @nusingapore.bsky.social in the fall! More about our work on vascular mechanobiology in health & disease mechano-medicine-lab.com
Reposted by Shailaja Seetharaman
The first objective of IMBA is to make its scientists successful. Let us help you turn ideas into discovery! IMBA is hiring a Junior Group Leader in the molecular life sciences. Apply below. #hiring #biology #research #groupleader #europe
April 28, 2025 at 7:00 AM
The first objective of IMBA is to make its scientists successful. Let us help you turn ideas into discovery! IMBA is hiring a Junior Group Leader in the molecular life sciences. Apply below. #hiring #biology #research #groupleader #europe
Reposted by Shailaja Seetharaman
🌿✨ Calling all mechanobiologists, bioengineers, and curious minds! ✨🌿
Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations.
📅 06-12 July
📍 Quy Nhon, Vietnam
🔗 icisequynhon.com/conferences/...
Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations.
📅 06-12 July
📍 Quy Nhon, Vietnam
🔗 icisequynhon.com/conferences/...
Mechanobiology 2025
icisequynhon.com
April 10, 2025 at 9:53 AM
🌿✨ Calling all mechanobiologists, bioengineers, and curious minds! ✨🌿
Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations.
📅 06-12 July
📍 Quy Nhon, Vietnam
🔗 icisequynhon.com/conferences/...
Join us in Vietnam this year for an unforgettable Conference on Mechanobiology, where science meets culture in one of Southeast Asia’s most vibrant destinations.
📅 06-12 July
📍 Quy Nhon, Vietnam
🔗 icisequynhon.com/conferences/...
Reposted by Shailaja Seetharaman
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
April 11, 2025 at 8:35 AM
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
Reposted by Shailaja Seetharaman
Join us Friday April 11 for talks by David Hathcock @davidhathcock.bsky.social (Mechanisms for dissipation-enhanced adaptation & cooperative sensing in bacterial chemotaxis) & Shailaja Seetharaman @sseethar.bsky.social (Mechanosensitive LIM domain protein FHL2 tunes endothelial function) #biophysics
April 9, 2025 at 11:28 PM
Join us Friday April 11 for talks by David Hathcock @davidhathcock.bsky.social (Mechanisms for dissipation-enhanced adaptation & cooperative sensing in bacterial chemotaxis) & Shailaja Seetharaman @sseethar.bsky.social (Mechanosensitive LIM domain protein FHL2 tunes endothelial function) #biophysics
Reposted by Shailaja Seetharaman
Awesome work showing a super clean + thoughtful application of using genomic deep learning models for discovery.
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model
www.cell.com/cell-genomic...
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model
www.cell.com/cell-genomic...
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model
Dalal et al. show how AI can be used to systematically uncover the sequence rules
that guide how signaling pathways interact with DNA inside cells. This work provides
a new lens for discovering the co...
www.cell.com
April 5, 2025 at 4:48 PM
Awesome work showing a super clean + thoughtful application of using genomic deep learning models for discovery.
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model
www.cell.com/cell-genomic...
Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model
www.cell.com/cell-genomic...
Reposted by Shailaja Seetharaman
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
March 28, 2025 at 11:15 AM
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
Reposted by Shailaja Seetharaman
Mike Sheetz (1946-2025) made immense contributions to our understanding of motor proteins, membrane biology, cytoskeleton and mechanobiology. Haguy Wolfenson, Gregory Giannone, and Martin Schwartz recall his life and work: rupress.org/jcb/article/...
March 28, 2025 at 1:45 PM
Mike Sheetz (1946-2025) made immense contributions to our understanding of motor proteins, membrane biology, cytoskeleton and mechanobiology. Haguy Wolfenson, Gregory Giannone, and Martin Schwartz recall his life and work: rupress.org/jcb/article/...
Reposted by Shailaja Seetharaman
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
March 20, 2025 at 1:51 PM
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻
🧵
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Reposted by Shailaja Seetharaman
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 10, 2025 at 1:33 PM
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Reposted by Shailaja Seetharaman
Looking for EGFR shrna plasmid urgently if someone has it🙏 if you could please check your connections it would be great as well!
Thank you
Thank you
March 12, 2025 at 8:34 PM
Looking for EGFR shrna plasmid urgently if someone has it🙏 if you could please check your connections it would be great as well!
Thank you
Thank you
Reposted by Shailaja Seetharaman
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...
www.biorxiv.org
March 10, 2025 at 3:36 AM
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Shailaja Seetharaman
Hot from the press: #CellMigration #vesicles #organelles
Jeppesen et al @mag2art.bsky.social lab introduce blebbisomes: organelle-rich motile vesicles, have immune checkpoint inhibitors, released by #cancer cells & used for #cellcomm
@naturecellbiology.bsky.social www.nature.com/articles/s41... 🧪🔬
Jeppesen et al @mag2art.bsky.social lab introduce blebbisomes: organelle-rich motile vesicles, have immune checkpoint inhibitors, released by #cancer cells & used for #cellcomm
@naturecellbiology.bsky.social www.nature.com/articles/s41... 🧪🔬
February 22, 2025 at 6:53 AM
Hot from the press: #CellMigration #vesicles #organelles
Jeppesen et al @mag2art.bsky.social lab introduce blebbisomes: organelle-rich motile vesicles, have immune checkpoint inhibitors, released by #cancer cells & used for #cellcomm
@naturecellbiology.bsky.social www.nature.com/articles/s41... 🧪🔬
Jeppesen et al @mag2art.bsky.social lab introduce blebbisomes: organelle-rich motile vesicles, have immune checkpoint inhibitors, released by #cancer cells & used for #cellcomm
@naturecellbiology.bsky.social www.nature.com/articles/s41... 🧪🔬
Reposted by Shailaja Seetharaman
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 26, 2025 at 9:13 AM
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...