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codebase here ! zenodo.org/records/1532...

thank you to all the amazing members/alumni of the Uchida lab and people with whom I had the privilege to discuss with @paulmasset.bsky.social @gershbrain.bsky.social @coolscontrol.bsky.social

This is an overlooked mechanism that impacts both the core understanding of dopamine signals in in reinforcement learning but also the study of psychiatric disorders and pharmacological interventions

We also show evidence in humans : indirect measurements of dopamine baseline correlates with asymmetric learning rates and explains the effects of dopamine pharmacological manipulations in a way consistent with the model

We show how only by accounting for this mechanism we could explain the effects of Habenula lesions , where mice showed signals of 'optimistic' biases after re-learning a task.