Sophia Shi
@sophiamshi.bsky.social
Rowland Fellow & PrincipaI Investigator at Harvard | brain aging + glycobiology
Reposted by Sophia Shi
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 9:58 PM
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...