Sonja Fritzsche
@sonjafritzsche.bsky.social
👩🔬 PhD Student @CosciaLab.bsky.social @MDC-berlin.bsky.social
🧬 Interested in Cancer and Multiomics
🔬 Combining Multiplex Imaging and Single-Cell Mass Spectrometry
🧬 Interested in Cancer and Multiomics
🔬 Combining Multiplex Imaging and Single-Cell Mass Spectrometry
Reposted by Sonja Fritzsche
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...
bit.ly
June 5, 2025 at 5:57 PM
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4
Reposted by Sonja Fritzsche
Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
July 17, 2025 at 11:09 AM
Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK
Reposted by Sonja Fritzsche
www.cell.com/cell-systems...
CosMx data by @brukerspatial.bsky.social
Second harmonics by Andrew Woehler
Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab
STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)
CosMx data by @brukerspatial.bsky.social
Second harmonics by Andrew Woehler
Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab
STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)
Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment
Pentimalli et al. extend imaging-based spatial transcriptomics to 3D and combine it
with ECM profiling. The multimodal analysis of cellular neighborhoods in a clinical
lung adenocarcinoma sample revea...
www.cell.com
April 16, 2025 at 10:40 AM
www.cell.com/cell-systems...
CosMx data by @brukerspatial.bsky.social
Second harmonics by Andrew Woehler
Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab
STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)
CosMx data by @brukerspatial.bsky.social
Second harmonics by Andrew Woehler
Immunofluorescence by @sonjafritzsche.bsky.social and @josenimo.bsky.social in Fabian Coscia lab
STIM for 3D alignment by @preibischs.bsky.social @nukappa.bsky.social et al (coming very soon!)
Reposted by Sonja Fritzsche
Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions!
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
Deep spatial proteomics of ovarian cancer precursor lesions delineates early disease changes and cell-of-origin signatures
High-grade serous ovarian cancer (HGSOC) is a devastating disease that is frequently detected at an advanced and incurable stage. Advances in ultrasensitive mass spectrometry-based spatial proteomics ...
www.biorxiv.org
March 20, 2025 at 8:59 AM
Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions!
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke