Paul Smyth
@smyth7.bsky.social
Director of AI/ML Engineering at GSK.ai. Ex-physicist. Mostly interested in deep learning for biological sequences. All opinions my own.
Pinned
Paul Smyth
@smyth7.bsky.social
· Feb 6
A overview blog on the good things being done in GSK AIML's Sequence Learning team
gsk.ai/blogs/gsk-s-...
Reposting with tags 🧬🧶
gsk.ai/blogs/gsk-s-...
Reposting with tags 🧬🧶
Reposted by Paul Smyth
"Adapting ProteinMPNN for antibody design without retraining"
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Adapting ProteinMPNN for antibody design without retraining
The neural network ProteinMPNN designs protein sequences capable of folding into predefined tertiary structures and quaternary assemblies. It has become widely used due to its high success rates when ...
www.biorxiv.org
May 15, 2025 at 4:30 PM
"Adapting ProteinMPNN for antibody design without retraining"
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted
Reposted by Paul Smyth
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
December 3, 2024 at 3:27 AM
Three BioML starter packs now!
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
Pack 3: go.bsky.app/NAKYUok
DM if you want to be included (or nominate people who should be!)
Reposted by Paul Smyth
Two BioML starter packs now:
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
DM if you want to be included (or nominate people who should be!)
Anybody have a bioml starter pack?
November 18, 2024 at 5:09 PM
Two BioML starter packs now:
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
DM if you want to be included (or nominate people who should be!)
Pack 1: go.bsky.app/2VWBcCd
Pack 2: go.bsky.app/Bw84Hmc
DM if you want to be included (or nominate people who should be!)
Reposted by Paul Smyth
The protein design & informatics group at GSK is hiring in switzerland - looking for experience w/ ML (LLMs, GNNs, etc) and/or classical computational structural biology techniques
GSK hiring Investigator, Protein Design in Baar, Zug, Switzerland | LinkedIn
Posted 2:18:02 AM. Site Name: UK - Hertfordshire - Stevenage, Baar OnyxPosted Date: Feb 8 2024Investigator, Protein…See this and similar jobs on LinkedIn.
www.linkedin.com
February 12, 2024 at 7:36 PM
The protein design & informatics group at GSK is hiring in switzerland - looking for experience w/ ML (LLMs, GNNs, etc) and/or classical computational structural biology techniques
A overview blog on the good things being done in GSK AIML's Sequence Learning team
gsk.ai/blogs/gsk-s-...
Reposting with tags 🧬🧶
gsk.ai/blogs/gsk-s-...
Reposting with tags 🧬🧶
February 6, 2024 at 7:59 AM
A overview blog on the good things being done in GSK AIML's Sequence Learning team
gsk.ai/blogs/gsk-s-...
Reposting with tags 🧬🧶
gsk.ai/blogs/gsk-s-...
Reposting with tags 🧬🧶
Reposted by Paul Smyth
Hi all, The #livingphysics feed is live! If you are interested in the physics of life or #livingmatter, please save and pin the feed. If you do, please also "like" it as it is how I keep track of interest. 🦫🦋 #evosky 🧪 🧬🧶 🔬 🐋🌱
bsky.app/profile/did:...
bsky.app/profile/did:...
January 16, 2024 at 7:13 AM
Hi all, The #livingphysics feed is live! If you are interested in the physics of life or #livingmatter, please save and pin the feed. If you do, please also "like" it as it is how I keep track of interest. 🦫🦋 #evosky 🧪 🧬🧶 🔬 🐋🌱
bsky.app/profile/did:...
bsky.app/profile/did:...
Reposted by Paul Smyth
Now comes the hard part of figuring out what all these damn things do
1.17B proteins from 26,931 metagenomes with no similarity to anything in reference genomes. Cluster into 106,198 novel clusters with more than 100 members and predict structures!
@sokrypton.org
www.nature.com/articles/s41...
@sokrypton.org
www.nature.com/articles/s41...
October 16, 2023 at 4:52 PM
Now comes the hard part of figuring out what all these damn things do