Stéphane Lemaire
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slemaire75.bsky.social
Stéphane Lemaire
@slemaire75.bsky.social
120 followers 110 following 1 posts
Director & Co-founder Paris Biofoundry at Sorbonne University
Chief Innovation Officer & Co-founder Biomemory
Team leader at LCQSB
Research Director CNRS
Posts Replies Media Videos
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
🌍It was a great honor to host #BriardoLlorente from the #AustralianGenomeFoundry at the #ParisBiofoundry!

We exchanged insights, experiences and collaboration opportunities, and toured the Sorbonne Foundry to showcase our cutting-edge facilities.
@arccoesb.bsky.social @parisbiofoundry.bsky.social
May 15, 2025 at 1:28 PM
Reposted by Stéphane Lemaire
oborkowski.bsky.social
Design of a Modular Inducible Circuit for Pulsatile Population
Control of Engineered Bacteria
doi.org/10.1101/2025...
May 5, 2025 at 1:37 PM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
🚀 The #DNAfoundry at @parisbiofoundry.bsky.social is now fully assembled!

A new hub for #highthroughput DNA design, #assembly & #sequencing, accelerating #SyntheticBiology research.🔬✨

@cnrs.fr @sorbonne-universite.fr @genopole.bsky.social @institutcurie.bsky.social @inrae-france.bsky.social
May 5, 2025 at 1:15 PM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
📢 The SC-DNA 2025 registration deadline is extended to May 31st!

Register now to attend the Storage & Computing with DNA 2025 conference (June 19-21, @sorbonne-universite.fr)! 📷

🔗 premc.org/storage-comp...

#DNADataStorage #ComputingWithDNA #SCDNA2025
April 23, 2025 at 8:32 AM
Reposted by Stéphane Lemaire
elife.bsky.social
Introducing SAVEMONEY, AKA ‘Simple Algorithm for Very Efficient Multiplexing of Oxford Nanopore Experiments for You’

A new tool offering a faster, cheaper computational approach to democratise whole-plasmid sequencing.
buff.ly/ov7YumB
Examples of the pre-survey outputs.
April 14, 2025 at 10:02 AM
Reposted by Stéphane Lemaire
dnadatastorage.bsky.social
💾 🧬 Arrange your summer travel now to these great conferences: tinyurl.com/597uthcu
• Storage & Computing with DNA, June 19-21, Paris
• New Trends in DNA-Based Data Storage, June 3-6, Prague
• Symposium on Chemistry of Nucleic Acid Components, June 8-13, Český Krumlov
March 27, 2025 at 5:34 PM
Reposted by Stéphane Lemaire
epcrocha.bsky.social
Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective!
Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.
March 27, 2025 at 6:45 PM
Reposted by Stéphane Lemaire
sramundo.bsky.social
Interested in photosynthetic organisms? Looking for a space to focus on research and kick-start your journey as a group leader? We’d love for you to join us. We offer an incredibly competitive package—on par with about 2 ERC grants for 8 years—and a collaborative environment unlike anywhere else 1/2
gmivienna.bsky.social Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · Mar 17
Join the GMI as a Junior Group Leader! The GMI is seeking a talented scientist to lead an independent research group, addressing fundamental questions in molecular plant biology. More information is below.
March 27, 2025 at 10:07 PM
Reposted by Stéphane Lemaire
globalplantgpc.bsky.social
Rubisco enzyme is responsible for capturing CO2 from the atmosphere, crucial for photosynthesis. Recent research has mapped mutant Rubisco molecules which could revolutionize plant CO2 assimilation & adapt to future climates

buff.ly/OLYpwtX v @innovativegenomics.bsky.social #PlantScience #Science
Image: Activated and unliganded RuBisCO protein from Spinach. Credit: Taylor, T.C., Andersson, I./ Wikimedia Commons
March 21, 2025 at 6:24 PM
Reposted by Stéphane Lemaire
oborkowski.bsky.social
Timed batch inputs unlock significantly higher yields for enzymatic cascades
www.researchsquare.com/article/rs-5...
March 9, 2025 at 8:23 AM
Reposted by Stéphane Lemaire
earlhaminst.bsky.social
💬 “It’s important to recognise the importance of miniaturisation in #genomics for the future."

Two automation specialists from the Earlham Institute recently worked with the application development team at @sptlabtech.bsky.social on the development of firefly®.

@drkarimgharbi.bsky.social
Case Study: Applying automation expertise to support new technology development
The Earlham Institute was awarded a Flexible Talent Mobility Award (FTMA) from BBSRC – designed to facilitate short-term exchanges between academic or industrial institutions – to place two…
buff.ly
March 8, 2025 at 1:00 PM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
🚨 Deadline Extension for Storage and Computing with DNA 2025 🚨
🔹 New abstract submission deadline: March 21, 2025
🔹 New registration deadline: April 21, 2025
premc.org/storage-comp...

@dnadatastorage.bsky.social @biomemory.com
@sorbonne-universite.fr @slemaire75.bsky.social
@pcrozet.bsky.social
March 3, 2025 at 3:46 PM
slemaire75.bsky.social
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus | Science www.science.org/doi/10.1126/...
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 8, 2025 at 12:43 PM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
www.nature.com/articles/s41...
Design and regulation of engineered bacteria for environmental release - Nature Microbiology
Chemla et al. review the release of bacteria into the environment and propose engineering strategies to help improve performance and reduce risk.
www.nature.com
February 5, 2025 at 2:11 PM
Reposted by Stéphane Lemaire
sara-truji.bsky.social
Yesterday, we had the pleasure at @leibnizinm.bsky.social to hear Dr Lemaire from the @parisbiofoundry.bsky.social on how DNA can be used for data storage 🧪 and the amazing capabilities of the biofoindry! Such a joy 🙂 Here my sketchnotes✏️
February 5, 2025 at 4:37 PM
Reposted by Stéphane Lemaire
rightardia.bsky.social
"Chlorella Vulgaris is a freshwater microalga rich in protein, lipids, carbohydrates, vitamins, and minerals. Unlike conventional agriculture, which requires extensive land and water resources, it can be cultivated sustainably with a minimal footprint.

www.sciencedaily.com/releases/202...
February 2, 2025 at 1:54 AM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
📢 Big news at the Paris Biofoundry!

We’ve welcomed the Echo 650T Series Acoustic Liquid Handler from #BeckmanCoulter .

With contact-free acoustic transfers down to 2.5 nL, this game-changing tool enhances assay miniaturization and boosts efficiency for #DNAassembly, #DrugDiscovery and more!
January 29, 2025 at 4:05 PM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
📢 Big news at the Paris Biofoundry!

We’ve just received the Orbitrap Ascend Tribrid Mass Spectrometer (MultiOmics model). A game-changer for #Proteomics, #Metabolomics & #MultiOmics research, it’s here to empower innovation in synthetic biology & biotherapies.

@thermofishersci.bsky.social
December 6, 2024 at 5:04 PM
Reposted by Stéphane Lemaire
mpimicrobiomarburg.bsky.social
Exciting opportunity! Max Planck Institute for Terrestrial Microbiology is looking for a Head of the DNA-Biofoundry MaxGENESYS. Join us in vibrant #Marburg - apply by 15 February 2025. #ScienceJobs #SyntheticBiology #Biofoundry @maxplanck.de
Job opening for the Head of the Max Planck DNA Biofoundry for automated DNA assembly. Applications are invited for a full time scientist position to head a Core Facility for DNA assembly / DNA Biofoundry at the Max Planck Institute (MPI) for Terrestrial Microbiology in Marburg, Germany (http://www.mpi-marburg.mpg.de). Further information can be obtained from https://www.mpi-marburg.mpg.de/148510/e_open_positions.
January 20, 2025 at 2:44 PM
Reposted by Stéphane Lemaire
c0nc0rdance.bsky.social
Unlike our cells, each of which becomes terminally differentiated (eventually), Volvox cells retain the ability to nimbly shift functions.

But also unlike single-celled relatives like Chlamydomonas, they don't have to undergo major changes to go from somatic (body) to gonidial (reproductive) forms.
From: "Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation" Matt et al (2016) Text: "Fig. 1. Volvox carteri body plan and cell types. Center, an adult vegetative Volvox spheroid with two distinct cell types: ~2000 small, flagellated somatic cells (right inset) and ~16 large, aflagellate germ cells called gonidia (left inset). Somatic cells are on the outer surface of the spheroid with flagella oriented towards the exterior. Gonidia are just beneath the somatic cell layer in the posterior hemisphere. All cells are embedded within a clear, compartmentalized extracellular matrix. Anterior (A) and posterior (P) poles of the spheroid are labeled."
January 25, 2025 at 10:00 PM
Reposted by Stéphane Lemaire
oborkowski.bsky.social
Cell-Free Synthesis System: An Accessible Platform from Biosensing to Biomanufacturing
doi.org/10.1016/j.mi...
February 2, 2025 at 11:57 AM
Reposted by Stéphane Lemaire
parisbiofoundry.bsky.social
Randomizing the human genome by engineering recombination between repeat elements | Science www.science.org/doi/10.1126/...
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
www.science.org
February 2, 2025 at 12:26 PM
Reposted by Stéphane Lemaire
stjle.bsky.social
Cell-Free PURE System: Evolution and Achievements

www.sciencedirect.com/science/arti...

#CellFree #CFPS #SynBio
Cell-Free PURE System: Evolution and Achievements
The cell-free protein synthesis (CFPS) system, as a technical core of synthetic biology, can simulate the transcription and translation process in an …
www.sciencedirect.com
January 11, 2025 at 12:05 PM
Reposted by Stéphane Lemaire
synbiobeta.bsky.social
🦠 When Bacteria Go Gel! 🦠
Researchers discovered that in polymer-rich environments, like mucus in cystic fibrosis, bacteria form tangled “cables”- a living Jell-O effect!

read more: www.synbiobeta.com/read/when-ba...

#ScienceFacts #Microbiology #Caltech
When Bacteria Go Gel: The Sticky Science of Microbial Cables - SynBioBeta
www.synbiobeta.com
January 29, 2025 at 12:25 AM