Sarah Kim-Hellmuth
@skimhellmuth.bsky.social
Human Geneticist, Emmy Noether Group Leader at Helmholtz Munich & Dr. von Hauner Children‘s Hospital, University Hospital LMU Munich, Germany, Member of Die Junge Akademie
Reposted by Sarah Kim-Hellmuth
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Disease-associated loci share properties with response eQTLs under common environmental exposures
Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...
www.biorxiv.org
June 10, 2025 at 2:20 PM
If we want to connect genetic variation to disease, we need to move beyond baseline conditions. Our study shows that dynamic, context-specific regulation holds the key to understanding many unexplained GWAS signals. The preprint again:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...