Simon Wiegert
@simwieg.bsky.social
Neuroscientist looking at life through lenses. Running a lab when not teaching physiology. Passionate about optogenetics, imaging, synapses and neuromodulation. Otherwise:🏃🚴🎵
www.umm.uni-heidelberg.de/medical-faculty-mannheim/neurophysiology
www.umm.uni-heidelberg.de/medical-faculty-mannheim/neurophysiology
Reposted by Simon Wiegert
Dopamine ≠ reward but turns out, also not the learning molecule we thought.
If DA RPE is the emperor, this work SCREAMS it was running naked all the time.
This paper got quite some attention recently. Let's simplify it a bit.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
If DA RPE is the emperor, this work SCREAMS it was running naked all the time.
This paper got quite some attention recently. Let's simplify it a bit.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
October 30, 2025 at 11:36 AM
Dopamine ≠ reward but turns out, also not the learning molecule we thought.
If DA RPE is the emperor, this work SCREAMS it was running naked all the time.
This paper got quite some attention recently. Let's simplify it a bit.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
If DA RPE is the emperor, this work SCREAMS it was running naked all the time.
This paper got quite some attention recently. Let's simplify it a bit.
A🧵with my toy model and notes:
#neuroskyence #compneuro #NeuroAI
...been doing this already a lot ;) Very easy
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 9:37 AM
...been doing this already a lot ;) Very easy
Reposted by Simon Wiegert
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
September 12, 2025 at 3:21 PM
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
Reposted by Simon Wiegert
🚨 8 PhD positions in GPCR signaling! The research group “DynOrg"(@dfg.de, @simwieg.bsky.social) is hiring doctoral researchers to study how GPCRs shape brain, heart & behavior – combining optogenetics & physiology. 🌍 7 labs across Germany
🗓️ Apply by Aug 31, 2025
👉 www.for5807.de/en/open-posi...
🗓️ Apply by Aug 31, 2025
👉 www.for5807.de/en/open-posi...
August 20, 2025 at 4:10 PM
🚨 8 PhD positions in GPCR signaling! The research group “DynOrg"(@dfg.de, @simwieg.bsky.social) is hiring doctoral researchers to study how GPCRs shape brain, heart & behavior – combining optogenetics & physiology. 🌍 7 labs across Germany
🗓️ Apply by Aug 31, 2025
👉 www.for5807.de/en/open-posi...
🗓️ Apply by Aug 31, 2025
👉 www.for5807.de/en/open-posi...
Reposted by Simon Wiegert
New Research Unit in Basic Biomedical Research: German Research Foundation provides approx. five million euros in funding www.uni-heidelberg.de/en/newsroom/...
New Research Unit in Basic Biomedical Research
www.uni-heidelberg.de
July 25, 2025 at 11:27 AM
New Research Unit in Basic Biomedical Research: German Research Foundation provides approx. five million euros in funding www.uni-heidelberg.de/en/newsroom/...
Reposted by Simon Wiegert
🚀 Big news from our @monikakscholz.bsky.social lab! We’re part of DynOrg, a new @dfg.de-funded Research Unit exploring how #GPCR signaling coordinates organ function & animal behavior — from heartbeat to foraging. 🧠💓
#FOR #neurotransmitters
#FOR #neurotransmitters
July 23, 2025 at 9:20 AM
🚀 Big news from our @monikakscholz.bsky.social lab! We’re part of DynOrg, a new @dfg.de-funded Research Unit exploring how #GPCR signaling coordinates organ function & animal behavior — from heartbeat to foraging. 🧠💓
#FOR #neurotransmitters
#FOR #neurotransmitters
Reposted by Simon Wiegert
Led by @simwieg.bsky.social from @uniheidelberg.bsky.social, DynOrg is one of 7 new DFG Research Units, supported for up to 8 years. We're thrilled to be on board! 🔬🇩🇪
#GPCR #Neuroscience #DynOrg #DFG #WormLab
#GPCR #Neuroscience #DynOrg #DFG #WormLab
July 23, 2025 at 9:20 AM
Led by @simwieg.bsky.social from @uniheidelberg.bsky.social, DynOrg is one of 7 new DFG Research Units, supported for up to 8 years. We're thrilled to be on board! 🔬🇩🇪
#GPCR #Neuroscience #DynOrg #DFG #WormLab
#GPCR #Neuroscience #DynOrg #DFG #WormLab
A must-read (in my humble opinion :)) if you plan to target the locus coeruleus in the rodent system. Selectivity and specificity strongly vary between strategies and mouse lines. But no need to worry: we provide tools and strategies to overcome those limitations.
This study reveals substantial heterogeneity in #transgene expression patterns when using different strategies to virally transduce #NoradrenergicNeurons of the #LocusCoeruleus, highlighting the need for caution to avoid misinterpretations when studying LC function @plosbiology.org 🧪 plos.io/3IehTKb
July 8, 2025 at 4:11 PM
A must-read (in my humble opinion :)) if you plan to target the locus coeruleus in the rodent system. Selectivity and specificity strongly vary between strategies and mouse lines. But no need to worry: we provide tools and strategies to overcome those limitations.
Reposted by Simon Wiegert
Förderentscheidungen zu #Forschungsgruppen durch den Hauptausschuss der DFG im Rahmen der Jahresversammlung: 7 Neueinrichtungen, 3 Verlängerungen. Die neuen Forschungsgruppen erhalten insges. rund 33 Mio. € für die erste Förderperiode. Mehr zu den Themen / Institutionen: www.dfg.de/de/service/p...
July 2, 2025 at 1:06 PM
Förderentscheidungen zu #Forschungsgruppen durch den Hauptausschuss der DFG im Rahmen der Jahresversammlung: 7 Neueinrichtungen, 3 Verlängerungen. Die neuen Forschungsgruppen erhalten insges. rund 33 Mio. € für die erste Förderperiode. Mehr zu den Themen / Institutionen: www.dfg.de/de/service/p...
Lab outing 2025. Beautiful weather, beautiful wine, beautiful people
June 20, 2025 at 8:14 PM
Lab outing 2025. Beautiful weather, beautiful wine, beautiful people
Reposted by Simon Wiegert
🎉Congratulations Heidelberg University!👏
📣With three successful Clusters of Excellence applications, Heidelberg can compete again for the status as a University of Excellence‼️
The existing cluster 3DMM2O will receive further funding, plus the new initiatives SynthImmune & GreenRobust.
#Excellence
📣With three successful Clusters of Excellence applications, Heidelberg can compete again for the status as a University of Excellence‼️
The existing cluster 3DMM2O will receive further funding, plus the new initiatives SynthImmune & GreenRobust.
#Excellence
May 23, 2025 at 6:27 AM
🎉Congratulations Heidelberg University!👏
📣With three successful Clusters of Excellence applications, Heidelberg can compete again for the status as a University of Excellence‼️
The existing cluster 3DMM2O will receive further funding, plus the new initiatives SynthImmune & GreenRobust.
#Excellence
📣With three successful Clusters of Excellence applications, Heidelberg can compete again for the status as a University of Excellence‼️
The existing cluster 3DMM2O will receive further funding, plus the new initiatives SynthImmune & GreenRobust.
#Excellence
Every lab should have a Bell of Glory. Here is ours and it sounds great
May 14, 2025 at 8:30 PM
Every lab should have a Bell of Glory. Here is ours and it sounds great
Reposted by Simon Wiegert
🚨We have an open position in the lab for the engineering of new #optogenetic tools for light control of #subcellular biology!💡🧠🔬 Interested? Get in touch or apply 👍
karriere.charite.de/en/job-vacan...
karriere.charite.de/en/job-vacan...
Researcher Subcellular Optogenetics at the Neurosciences Research Center DM.65.25
part-time | 28.03.2025 | Campus Charité Mitte
karriere.charite.de
March 20, 2025 at 12:17 AM
🚨We have an open position in the lab for the engineering of new #optogenetic tools for light control of #subcellular biology!💡🧠🔬 Interested? Get in touch or apply 👍
karriere.charite.de/en/job-vacan...
karriere.charite.de/en/job-vacan...
Reposted by Simon Wiegert
Functional Connectivity Shapes Spine Stability in the Hippocampus https://www.biorxiv.org/content/10.1101/2025.02.07.637112v1
February 9, 2025 at 4:15 AM
Functional Connectivity Shapes Spine Stability in the Hippocampus https://www.biorxiv.org/content/10.1101/2025.02.07.637112v1
Reposted by Simon Wiegert
Cool experimental design by @simwieg.bsky.social's lab with optogenetics + calcium imaging: how place cells in CA1 are affected by stimulation of contralateral CA3. They observe less an induction of place fields but somewhat random shifts of existing place fields: www.biorxiv.org/content/10.1...
January 31, 2025 at 11:01 PM
Cool experimental design by @simwieg.bsky.social's lab with optogenetics + calcium imaging: how place cells in CA1 are affected by stimulation of contralateral CA3. They observe less an induction of place fields but somewhat random shifts of existing place fields: www.biorxiv.org/content/10.1...
A major step forward in elucidating the relationship between synaptic plasticity at individual hippocampal synapses and neuronal encoding of external information in the living brain.
Every moment we remember is encoded by changes in the strength of connections between brain cells, links called synapses. In a new @natureportfolio.bsky.social study, the Polleux and Losonczy labs have imaged these changes as an animal forms memories! zuckermaninstitute.columbia.edu/new-peek-neu...
December 19, 2024 at 8:23 AM
A major step forward in elucidating the relationship between synaptic plasticity at individual hippocampal synapses and neuronal encoding of external information in the living brain.
Reposted by Simon Wiegert
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
December 17, 2024 at 1:15 AM
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
On the way to Berlin to celebrate Peter Hegemann's 70th birthday with a surprise symposium (he's not yet on bsky - no risk of spoiling it).
Looking forward to seeing many friends from all over the world. Peter has been a central figure in building this community.
#optogenetics
Looking forward to seeing many friends from all over the world. Peter has been a central figure in building this community.
#optogenetics
December 13, 2024 at 9:53 AM
On the way to Berlin to celebrate Peter Hegemann's 70th birthday with a surprise symposium (he's not yet on bsky - no risk of spoiling it).
Looking forward to seeing many friends from all over the world. Peter has been a central figure in building this community.
#optogenetics
Looking forward to seeing many friends from all over the world. Peter has been a central figure in building this community.
#optogenetics
Reposted by Simon Wiegert
(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why
November 25, 2024 at 3:22 PM
(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why
Reposted by Simon Wiegert
Are you building a patch-clamp setup, and would like a cheap heating system? Have you ever wondered how temperature changes the membrane properties of MSNs? Then you might like our latest paper, out now!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A low-cost perfusion heating system for slice electrophysiology - Scientific Reports
Scientific Reports - A low-cost perfusion heating system for slice electrophysiology
www.nature.com
November 18, 2024 at 7:04 PM
Are you building a patch-clamp setup, and would like a cheap heating system? Have you ever wondered how temperature changes the membrane properties of MSNs? Then you might like our latest paper, out now!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Simon Wiegert
We’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin
November 3, 2024 at 12:22 PM
We’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin