Sihao Lu
@sihaolu.bsky.social
Postdoc @rockefelleruniv.bsky.social with the Hudspeth Lab
Astrocytes, auditory processing, two-photon, lightsheet, ephys, machine learning.
Previously PhD @imperialcollegeldn.bsky.social
Antwerpenaar.
Astrocytes, auditory processing, two-photon, lightsheet, ephys, machine learning.
Previously PhD @imperialcollegeldn.bsky.social
Antwerpenaar.
Pinned
Sihao Lu
@sihaolu.bsky.social
· Nov 14
Composite receptive fields in the mouse auditory cortex
Abstract figure legend We investigated how auditory cortical neurons in mice represent complex natural stimuli by presenting them with mouse ultrasonic vocalisations (USVs) and pitch-shifted starling...
physoc.onlinelibrary.wiley.com
Just repopulating the profile with some old stuff.
My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Sihao Lu
Thankful for this blog piece by @ptrrupprecht.bsky.social on the Dirigo project. Glad you liked the posts!
gcamp6f.com/2025/11/14/d...
gcamp6f.com/2025/11/14/d...
Dirigo: a future Python alternative to Scanimage?
Over the last 20 years, many microscopes that are capable of resonant scanning two-photon microscopy have converged on using ScanImage, a powerful software package with many strengths but also two …
gcamp6f.com
November 21, 2025 at 4:24 PM
Thankful for this blog piece by @ptrrupprecht.bsky.social on the Dirigo project. Glad you liked the posts!
gcamp6f.com/2025/11/14/d...
gcamp6f.com/2025/11/14/d...
Some of the work I did for my PhD finally on biorxiv! We study calcium responses of astrocytes and neurons in vivo in response to ultrasonic vocalisations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Astrocytes and neurons encode natural stimuli with partially shared but distinct composite receptive fields
Astrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ...
www.biorxiv.org
October 7, 2025 at 1:22 PM
Some of the work I did for my PhD finally on biorxiv! We study calcium responses of astrocytes and neurons in vivo in response to ultrasonic vocalisations
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sihao Lu
Shortly before his death last month, James Hudspeth and his team achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience
Researchers keep a mammalian cochlea alive outside the body for the first time - News
The technological breakthrough may improve our understanding of the cellular mechanisms behind hearing loss.
www.rockefeller.edu
September 10, 2025 at 3:34 PM
Shortly before his death last month, James Hudspeth and his team achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience
Reposted by Sihao Lu
Ants 🐜 coordinate their societies through smell 👃. They carry more odorant receptor genes than any other insect 🧬, yet each olfactory neuron must somehow select and express just one.
My brilliant former student Giacomo Glotzer and colleagues have discovered how:
www.biorxiv.org/content/10.1...
My brilliant former student Giacomo Glotzer and colleagues have discovered how:
www.biorxiv.org/content/10.1...
Transcriptional Interference Gates Monogenic Odorant Receptor Expression in Ants
Communication is crucial to social life, and in ants, it is mediated primarily through olfaction. Ants have more odorant receptor (OR) genes than any other group of insects, generated through tandem d...
www.biorxiv.org
August 27, 2025 at 4:06 PM
Ants 🐜 coordinate their societies through smell 👃. They carry more odorant receptor genes than any other insect 🧬, yet each olfactory neuron must somehow select and express just one.
My brilliant former student Giacomo Glotzer and colleagues have discovered how:
www.biorxiv.org/content/10.1...
My brilliant former student Giacomo Glotzer and colleagues have discovered how:
www.biorxiv.org/content/10.1...
It has been a great privilege to have worked with Jim. A truly inspiring individual who embodied a level of kindness, curiosity, and wisdom we should all aspire to.
We are deeply saddened to share that our friend and colleague Jim Hudspeth passed away on Saturday. We will remember and continue to be inspired by Jim’s integrity, his humility, and his unwavering commitment to discovery.
A. James Hudspeth, neuroscientist who unlocked secrets of hearing, has died - News
A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...
www.rockefeller.edu
August 18, 2025 at 9:12 PM
It has been a great privilege to have worked with Jim. A truly inspiring individual who embodied a level of kindness, curiosity, and wisdom we should all aspire to.
Reposted by Sihao Lu
Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish https://www.biorxiv.org/content/10.1101/2025.07.23.666336v1
July 25, 2025 at 3:15 PM
Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish https://www.biorxiv.org/content/10.1101/2025.07.23.666336v1
Reposted by Sihao Lu
We took the #ear ’s in-built amplifier out of the body, watched it work live, and saw that it runs near a state of #criticality, a knife-edge balance that lets us hear from whispers to thunderclaps and up to 20 kHz. Birds, reptiles, and insects exploit the same physics. #Biophysics shorturl.at/AkMz9
Amplification through local critical behavior in the mammalian cochlea | PNAS
Hearing hinges upon the ear’s ability to enhance its responsiveness by means of an
energy-expending active process that amplifies the very mechanic...
shorturl.at
July 15, 2025 at 3:08 PM
We took the #ear ’s in-built amplifier out of the body, watched it work live, and saw that it runs near a state of #criticality, a knife-edge balance that lets us hear from whispers to thunderclaps and up to 20 kHz. Birds, reptiles, and insects exploit the same physics. #Biophysics shorturl.at/AkMz9
Reposted by Sihao Lu
youtu.be/9zpWEOJWuD0?... Ventana imaging. The best 2p system. Fast, high rez, 3+ mm field-of-view. pacificoptica.com/ventana/ Turnkey systems, or parts.
Ventana Wide two-photon calcium imaging
YouTube video by Pacific Optica
youtu.be
February 25, 2025 at 1:31 AM
youtu.be/9zpWEOJWuD0?... Ventana imaging. The best 2p system. Fast, high rez, 3+ mm field-of-view. pacificoptica.com/ventana/ Turnkey systems, or parts.
Had a great time working with Nico on this!
Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain https://www.biorxiv.org/content/10.1101/2025.02.07.637118v1
February 9, 2025 at 10:00 AM
Had a great time working with Nico on this!
Checkout this Journal of Neurophysiology podcast where Andriy, Johnny and John talk about our work generating natural mouse vocalisations using generative adversarial networks:
www.podbean.com/ew/pb-xawkr-...
www.podbean.com/ew/pb-xawkr-...
JNP Micro Podcasts: Bidirectional Generative Adversarial Representation Learning for Natural Stimulus Synthesis
In this episode, coauthors Andriy S. Kozlov, Johnny Reilly, and John D. Goodwin discuss their recently published research titled "Bidirectional Generative Adversarial Representation Learning for Natur...
www.podbean.com
January 8, 2025 at 3:57 PM
Checkout this Journal of Neurophysiology podcast where Andriy, Johnny and John talk about our work generating natural mouse vocalisations using generative adversarial networks:
www.podbean.com/ew/pb-xawkr-...
www.podbean.com/ew/pb-xawkr-...
Super proud of both Johnny and John, they demonstrate a generative model for synthesising natural mouse vocalisations and show that these artificially generated vocalisations can be used to probe receptive field properties of neurons in real mice!
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Bidirectional generative adversarial representation learning for natural stimulus synthesis | Journal of Neurophysiology
Thousands of species use vocal signals to communicate with one another. Vocalizations carry rich information, yet characterizing and analyzing these complex, high-dimensional signals is difficult and ...
journals.physiology.org
November 14, 2024 at 4:51 PM
Super proud of both Johnny and John, they demonstrate a generative model for synthesising natural mouse vocalisations and show that these artificially generated vocalisations can be used to probe receptive field properties of neurons in real mice!
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Just repopulating the profile with some old stuff.
My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Composite receptive fields in the mouse auditory cortex
Abstract figure legend We investigated how auditory cortical neurons in mice represent complex natural stimuli by presenting them with mouse ultrasonic vocalisations (USVs) and pitch-shifted starling...
physoc.onlinelibrary.wiley.com
November 14, 2024 at 4:45 PM
Just repopulating the profile with some old stuff.
My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
My first ever paper; showing composite receptive fields in mouse auditory cortex in vivo. Great pleasure working on this as part of my PhD with Andriy Kozlov and others!
physoc.onlinelibrary.wiley.com/doi/10.1113/...