Matthew Macauley
@siglecdude.bsky.social
R.U. Lemieux Chair of Carbohydrate Chemistry
Professor, Department of Chemsitry
University of Alberta
Professor, Department of Chemsitry
University of Alberta
Reposted by Matthew Macauley
When glycan recognition is linked to immune response, you need fine tuning! 😎
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
June 22, 2025 at 10:42 AM
When glycan recognition is linked to immune response, you need fine tuning! 😎
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️
doi.org/10.1101/2025...
Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...
www.biorxiv.org
June 14, 2025 at 9:05 PM
Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...
New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions
Siglec-10 is a sialic acid-binding immunoglobulin-like lectin implicated in immune regulation, yet its molecular basis for ligand recognition and functional role in immune modulation remain poorly def...
www.biorxiv.org
June 12, 2025 at 1:26 PM
New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A little story we put together that I hope can be useful: pubs.rsc.org/en/content/a.... More to come on this work related to this in the future.
pubs.rsc.org
May 5, 2025 at 9:01 PM
A little story we put together that I hope can be useful: pubs.rsc.org/en/content/a.... More to come on this work related to this in the future.
Our review on the recent acceleration of research into carbohydrate Sulfation as as an enhancer of Siglec ligands: www.sciencedirect.com/science/arti...
Redirecting
kwnsfk27.r.eu-west-1.awstrack.me
May 5, 2025 at 8:54 PM
Our review on the recent acceleration of research into carbohydrate Sulfation as as an enhancer of Siglec ligands: www.sciencedirect.com/science/arti...
Highly recommended listening to @ghazeskandari.bsky.social if you are interested in immune cells of the brain.
Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi...
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h
April 30, 2025 at 3:27 AM
Highly recommended listening to @ghazeskandari.bsky.social if you are interested in immune cells of the brain.
We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...
Job Opening – A Postdoctoral fellow or Research Associate – Macauley Lab
macauleylab.ca
February 4, 2025 at 3:00 PM
We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...
Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs
Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...
pubs.acs.org
January 22, 2025 at 2:32 AM
Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Matthew Macauley
With the Wen lab and @siglecdude.bsky.social, we screening a library of sulfated glycan ligands against human Siglecs, and found that sulfation and sialylation patterns serve as important determinants of Siglec binding affinity and specificity #glycotime pubs.acs.org/doi/10.1021/...
Enzyme-Sialylation-Controlled Chemical Sulfation of Glycan Epitopes for Decoding the Binding of Siglec Ligands
Widely distributed in nature, sulfated glycan epitopes play important roles in diverse pathophysiological processes. However, due to their structural complexity, the preparation of glycan epitopes wit...
pubs.acs.org
November 24, 2024 at 5:44 PM
With the Wen lab and @siglecdude.bsky.social, we screening a library of sulfated glycan ligands against human Siglecs, and found that sulfation and sialylation patterns serve as important determinants of Siglec binding affinity and specificity #glycotime pubs.acs.org/doi/10.1021/...