Hi there, great! please dm me with your email address?

If you are enthusiastic, this is an ideal position for you to hone your leadership skills. Many initiatives, like FlyCROSS mentor-match, were the brainchild of our trainee reps. If you want to know more or be considered, reach out to me, @iamshef.bsky.social, or @shyama13.bsky.social by Nov 17! 3/

The #Flyboard and #FlyCROSS committee including me, Laurel @shyama13.bsky.social @jocmcdonald.bsky.social @frankmac.bsky.social @armstrongflylab.bsky.social & Jonathan look forward to having you on board.

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What are the consequences of persistent ISR activation in tissues that use ISR for homeostatic functions?

How does ISR regulate cellular biomechanical changes?

Is "turning off" ISR also a necessary for homeostasis?

Read more here and please RT! febs.onlinelibrary.wiley.com/doi/10.1111/...

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Several open questions remain, and we discuss each of the following to close out this review:

Is ISR a master regulator of metabolism?

Does it regulate "cellular memory"?

How do homeostatic and adaptive ISR functions differ in the same tissue?

5/ We found some interesting clues that suggest ISR could play an important role in influencing the robustness of various biological oscillators, across different time scales! (something yours truly is excited to investigate further!)

4/ Is ISR a driver of physiological aging? - we highlight emerging literature that suggests this is the case in the nervous system and skeletal system

3/ We highlight several known key functions of ISR in development, metabolic tissue function, tissue surveillance and cell competition...but there's more! We identified some emerging themes that could inform decades of future "stress" research"...some highlights 👇👇👇

2/ Our favourite stress signaling pathway, the Integrated Stress Response (ISR) moonlights in several tissues playing several critical homeostatic functions, across species!