Until today, the aggressiveness of prostate cancer has been assessed primarily using the Gleason grading system—an analysis of cancer tissue in a pathology laboratory that is highly subjective. An int...

APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Nature, Published online: 16 July 2025; doi:10.1038/d41586-025-02215-4 The US science crisis presents an opportunity to reinvent funding and management of the global research enterprise.

The Wellcome Photography Prize brings together visual stories of health, science and human experience.

Nature Reviews Cancer, Published online: 02 July 2025; doi:10.1038/s41568-025-00849-0Although disulfide stress in cancer cells under glucose starvation is known to trigger disulfidptosis, its role in the tumour microenvironment has remained unclear. A recent study in Nature Cell Biology reveals that in intratumoural CD8+ T cells, disulfidptosis promotes T cell exhaustion and thereby limits antitumour imunity.

An immigration crackdown makes the United States less attractive. These locations could steal its crown and make conferences more globally inclusive.

Nature Protocols, Published online: 12 June 2025; doi:10.1038/s41596-025-01188-yWe present a protocol for the design, fabrication and use of a microfluidic probe for nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI) that achieves a spatial resolution of 8–10 µm and 10-fold improvement in experimental throughput.

Lei et al. reveal that radiotherapy (RT) elevates mitochondrial copper and induces cuproptosis by upregulating CTR1 and depleting mitochondrial glutathione. Furthermore, BACH1 downregulation confers radioresistance by upregulating MT1E/X-mediated cuproptosis defense. Correspondingly, copper-loaded copper ionophores restore RT sensitivity by enhancing cuproptosis, highlighting a therapeutic strategy to overcome tumor radioresistance.

This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

SAVANA is a new tool designed for accurate detection of structural variations in clinical samples.

Explore the marvellous and mysterious world in your head.

Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

Nature Metabolism, Published online: 02 May 2025; doi:10.1038/s42255-025-01270-5NAD kinases have a crucial role in the de novo synthesis of the cofactor NADP+ by phosphorylating NAD+ to yield NADP+. A study by Flickinger et al. uses physiologically relevant cell culture media with low folic acid levels and identifies the cytosolic NAD kinase NADK as essential factor for supporting dihydrofolate reductase (DHFR) activity and folate-dependent nucleotide synthesis in cancer cells.

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Nature Metabolism, Published online: 10 April 2025; doi:10.1038/s42255-025-01283-0Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

Li et al. analyze CD8+ T cells collected from HNSCC patients treated with neoadjuvant immunotherapies. They show that different combination immunotherapies modulate CD8+ T cell functional states through distinct transcriptional and clonal dynamics, providing insights that will guide the development of future innovative immune interventions in treating cancers.

Nature - Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good.

Wang et al. advance bacteria-based metabolic therapy by developing DL@SFEc+ through dual-selection evolution. The evolved SFEc+ significantly enhances CySS uptake and desulfhydrase activity. Combined with DMXAA-loaded liposome, the DL@SFEc+ disrupts tumor nutrient influx and redox balance, showcasing effective antitumor capabilities and stability across various tumor models.

Lactobacilli are a principal microbial constituent in the human uterine cervix and vagina. Here, authors identify the stem cells in the human uterine cervix and the role of Lactobacilli metabolite in cervical stem cells and cervical cancers.