Sarah Shipley
@shipleysj.bsky.social
Neuroscience postdoc
Barry Lab, UCL
Hippocampus, Spatial Cognition, Memory, AD
Barry Lab, UCL
Hippocampus, Spatial Cognition, Memory, AD
Huge thanks to my collaborators on this: @caswell.bsky.social , @abrate.bsky.social, Robin Hayman and Dennis Chan (who aren’t on here).
November 28, 2024 at 12:20 PM
Huge thanks to my collaborators on this: @caswell.bsky.social , @abrate.bsky.social, Robin Hayman and Dennis Chan (who aren’t on here).
Place fields were less stable in the AD mice (this also improved across days). The stability of place cells correlated with the memory performance!
5/5
5/5
November 28, 2024 at 12:20 PM
Place fields were less stable in the AD mice (this also improved across days). The stability of place cells correlated with the memory performance!
5/5
5/5
Place cell stability decreased more rapidly in AD mice than WT’s. Importantly, stability increased in session 2 (following rest) in WT but not AD mice.
4/ 5
4/ 5
November 28, 2024 at 12:20 PM
Place cell stability decreased more rapidly in AD mice than WT’s. Importantly, stability increased in session 2 (following rest) in WT but not AD mice.
4/ 5
4/ 5
MUA rate in the rest between sessions was not different between AD and WT mice. BUT – recruitment of cells to MUAs, and the structure within MUAs, was reduced in the AD mice!
Both recruitment to MUAs and structure within MUAs were predictive of place cell stability.
3/5
Both recruitment to MUAs and structure within MUAs were predictive of place cell stability.
3/5
November 28, 2024 at 12:20 PM
MUA rate in the rest between sessions was not different between AD and WT mice. BUT – recruitment of cells to MUAs, and the structure within MUAs, was reduced in the AD mice!
Both recruitment to MUAs and structure within MUAs were predictive of place cell stability.
3/5
Both recruitment to MUAs and structure within MUAs were predictive of place cell stability.
3/5
APP NL-G-F mice (which avoid APP overexpression) had decreased memory performance in a radial-arm maze task.
Compared to WT’s, the AD mice were more likely to return to arms they had already visited in trial, rather than visiting unique arms. But they did improve across days!
2/5
Compared to WT’s, the AD mice were more likely to return to arms they had already visited in trial, rather than visiting unique arms. But they did improve across days!
2/5
November 28, 2024 at 12:20 PM
APP NL-G-F mice (which avoid APP overexpression) had decreased memory performance in a radial-arm maze task.
Compared to WT’s, the AD mice were more likely to return to arms they had already visited in trial, rather than visiting unique arms. But they did improve across days!
2/5
Compared to WT’s, the AD mice were more likely to return to arms they had already visited in trial, rather than visiting unique arms. But they did improve across days!
2/5