@semirkin.bsky.social
Proud to share this review based on recent studies from our and other labs. All credits to my great students Liangzi Li and Shem Scott who conducted some of these studies and wrote this thought-provoking review!
Emerging drivers of DNA repeat expansions url: portlandpress.com/biochemsoctr...
Emerging drivers of DNA repeat expansions url: portlandpress.com/biochemsoctr...
August 13, 2025 at 1:44 PM
Proud to share this review based on recent studies from our and other labs. All credits to my great students Liangzi Li and Shem Scott who conducted some of these studies and wrote this thought-provoking review!
Emerging drivers of DNA repeat expansions url: portlandpress.com/biochemsoctr...
Emerging drivers of DNA repeat expansions url: portlandpress.com/biochemsoctr...
origin of mirror repeats in the human genome url: academic.oup.com/nar/article/...
The origin of mirror repeats in the human genome
Abstract. Mirror DNA repeats were found in genomic DNA several decades ago, but their role and the mechanisms leading to their abundance have remained a my
academic.oup.com
July 2, 2025 at 11:39 AM
origin of mirror repeats in the human genome url: academic.oup.com/nar/article/...
My fantastic undergraduates at Stand up for Science rally in Boston today!
March 8, 2025 at 1:45 AM
My fantastic undergraduates at Stand up for Science rally in Boston today!
Reposted
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
February 21, 2025 at 4:20 PM
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
Reposted
Already bruised by the Trump administration’s first round of firings of federal workers, employees at NIH faced more bad news. NIH’s 27 institute directors were told this week that the agency must cut staffing back to 2019 levels, or at least 10% below its 2024 tally. scim.ag/3EP8gjy
More NIH job cuts coming? Agency's scientists already reeling after week of firings
NIH is appealing loss of some lab leaders among in-house research program while bracing for the next actions from the Trump administration
scim.ag
February 21, 2025 at 11:52 PM
Already bruised by the Trump administration’s first round of firings of federal workers, employees at NIH faced more bad news. NIH’s 27 institute directors were told this week that the agency must cut staffing back to 2019 levels, or at least 10% below its 2024 tally. scim.ag/3EP8gjy
Best holiday present: Our comprehensive review of triplex H-DNA has just come out in NAR Mol Medicine. I am indebted to two outstanding graduate students: Julia Hisey and Chiara Masnovo, whose enthusiasm, dedication and hard work made this review possible! academic.oup.com/narmolmed/ad...
Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease
Abstract. H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from chara
academic.oup.com
December 24, 2024 at 12:10 PM
Best holiday present: Our comprehensive review of triplex H-DNA has just come out in NAR Mol Medicine. I am indebted to two outstanding graduate students: Julia Hisey and Chiara Masnovo, whose enthusiasm, dedication and hard work made this review possible! academic.oup.com/narmolmed/ad...
Another week, another great paper! Kudos to the amazing grad student, Chiara Masnovo who single-handedly initiated and led the project, and arranged a terrific collaboration with the Aharoni lab from Ben-Gurion University, and to the great members of the two labs.
www.nature.com/articles/s41...?
Stabilization of expandable DNA repeats by the replication factor Mcm10 promotes cell viability - Nature Communications
DNA repeats can lengthen or shorten during their replication, which may lead to a human disease. Here, the authors discovered that an essential replication protein, Mcm10, counteracts instability of G...
www.nature.com
December 4, 2024 at 12:34 AM
Another week, another great paper! Kudos to the amazing grad student, Chiara Masnovo who single-handedly initiated and led the project, and arranged a terrific collaboration with the Aharoni lab from Ben-Gurion University, and to the great members of the two labs.
www.nature.com/articles/s41...?
Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab.
www.pnas.org/doi/10.1073/pnas.2413298121
www.pnas.org/doi/10.1073/pnas.2413298121
Recurrent DNA nicks drive massive expansions of (GAA)n repeats | PNAS
Over 50 hereditary degenerative disorders are caused by expansions of short tandem
DNA repeats (STRs). (GAA)n repeat expansions are responsible for...
www.pnas.org
November 25, 2024 at 9:08 PM
Our latest paper showing that DNA nicks drive expansions of both normal and disease-size alleles. All credit goes to a fantastic graduate student Liangzi Li as well as to a terrific team of current and former undergraduate and graduate students in the lab.
www.pnas.org/doi/10.1073/pnas.2413298121
www.pnas.org/doi/10.1073/pnas.2413298121