André Schneider, University of Bern
@schneian.bsky.social
Biochemist interested in mitochondria, trypanosomes and science in general
Pinned
A piece of science history about RNA, oxygen, and mice cages
There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.
www.embopress.org/doi/full/10....?
There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.
www.embopress.org/doi/full/10....?
Reposted by André Schneider, University of Bern
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
November 12, 2025 at 10:31 AM
What is the most profitable industry in the world, this side of the law? Not oil, not IT, not pharma.
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
It's *scientific publishing*.
We call this the Drain of Scientific Publishing.
Paper: arxiv.org/abs/2511.04820
Background: doi.org/10.1162/qss_...
Thread @markhanson.fediscience.org.ap.brid.gy 👇
Reposted by André Schneider, University of Bern
Schrödinger: Excuse me, miss, can I borrow that box for a science experiment?
Pandora: Sure, be my guest.
Pandora: Sure, be my guest.
November 9, 2025 at 5:38 AM
Schrödinger: Excuse me, miss, can I borrow that box for a science experiment?
Pandora: Sure, be my guest.
Pandora: Sure, be my guest.
Reposted by André Schneider, University of Bern
- Picture by Raymond Gosling and Rosalind Franklin, King's College
- DNA by Rudolf Signer, University of Bern
- DNA by Rudolf Signer, University of Bern
March 7, 2025 at 4:36 PM
- Picture by Raymond Gosling and Rosalind Franklin, King's College
- DNA by Rudolf Signer, University of Bern
- DNA by Rudolf Signer, University of Bern
Reposted by André Schneider, University of Bern
Holy smokes!!!!
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 8, 2025 at 12:16 AM
Holy smokes!!!!
Reposted by André Schneider, University of Bern
Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training
November 26, 2024 at 9:12 PM
Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training
Reposted by André Schneider, University of Bern
Paper by the Schneider lab( @schneian.bsky.social ) & collaborators w/co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome" @febsj.bsky.social nccr-rna-and-disease.ch/news/article...
October 27, 2025 at 8:02 AM
Paper by the Schneider lab( @schneian.bsky.social ) & collaborators w/co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome" @febsj.bsky.social nccr-rna-and-disease.ch/news/article...
Multiple so called "quality control checks" by the journal almost killed us. - But now it is out!
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
FEBS Press
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we ...
doi.org
October 23, 2025 at 6:27 PM
Multiple so called "quality control checks" by the journal almost killed us. - But now it is out!
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
A novel mito. protein import factor is only essential in T. brucei without kDNA. – Check it out.
Congrats, to the first authors Corinne and Salome and to all our coauthors.
doi.org/10.1111/febs...
Reposted by André Schneider, University of Bern
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
October 13, 2025 at 12:55 PM
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
Reposted by André Schneider, University of Bern
Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.
September 19, 2025 at 9:58 AM
Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.
...and now something for RNA enthusiasts
@nccr-rna-disease.bsky.social
The function of the vault complex has finally been solved: it is a lampshade.
@nccr-rna-disease.bsky.social
The function of the vault complex has finally been solved: it is a lampshade.
September 24, 2025 at 12:21 PM
...and now something for RNA enthusiasts
@nccr-rna-disease.bsky.social
The function of the vault complex has finally been solved: it is a lampshade.
@nccr-rna-disease.bsky.social
The function of the vault complex has finally been solved: it is a lampshade.
Another case of convergent evolution?
September 20, 2025 at 1:07 PM
Another case of convergent evolution?
Convergent Evolution? – Spiral staircase in the “Église Saint-Catherine” in Loix, France
September 20, 2025 at 12:45 PM
Convergent Evolution? – Spiral staircase in the “Église Saint-Catherine” in Loix, France
Reposted by André Schneider, University of Bern
Congrats to all authors, especially Lim who had an impressive PhD viva last week! TAC is a very interesting structure linking mitochondrial DNA and basal bodies in trypanosomes
September 19, 2025 at 11:22 AM
Congrats to all authors, especially Lim who had an impressive PhD viva last week! TAC is a very interesting structure linking mitochondrial DNA and basal bodies in trypanosomes
The trypanosomal TAC of is required for mitochondrial DNA segregation: Discovery of the novel TAC53 subunit and the tubular arrangement of the TAC filaments
Joint study by the Ochsenreiter and Schneiderlabs.
👏 to 1. Author Lim.
journals.plos.org/plospathogen...
#mitochondria #mtDNA #Trypanosoma
Joint study by the Ochsenreiter and Schneiderlabs.
👏 to 1. Author Lim.
journals.plos.org/plospathogen...
#mitochondria #mtDNA #Trypanosoma
Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex
Author summary Trypanosoma brucei, is the causative agent of human African sleeping sickness and nagana in cattle. The eukaryotic parasite relies on the faithful inheritance of its singular mitochondr...
journals.plos.org
September 18, 2025 at 9:49 AM
The trypanosomal TAC of is required for mitochondrial DNA segregation: Discovery of the novel TAC53 subunit and the tubular arrangement of the TAC filaments
Joint study by the Ochsenreiter and Schneiderlabs.
👏 to 1. Author Lim.
journals.plos.org/plospathogen...
#mitochondria #mtDNA #Trypanosoma
Joint study by the Ochsenreiter and Schneiderlabs.
👏 to 1. Author Lim.
journals.plos.org/plospathogen...
#mitochondria #mtDNA #Trypanosoma
Reposted by André Schneider, University of Bern
so happy to have Katie as a colleague !
Nice interview to Katie Peichel @currentbiology.bsky.social
I completely agree with her claims for more funding for curiosity-driven research, basic Science... Science.
www.cell.com/current-biol...
I completely agree with her claims for more funding for curiosity-driven research, basic Science... Science.
www.cell.com/current-biol...
Catherine Peichel
Interview with Katie Peichel, who studies the evolutionary genetics of sticklebacks
at the University of Bern, Switzerland.
www.cell.com
September 10, 2025 at 3:45 PM
so happy to have Katie as a colleague !
Reposted by André Schneider, University of Bern
Sie haben friedliche Menschen gewaltsam attackiert! Was haben Sie zu Ihrer Verteidigung zu sagen? Ach? Sie dachten, das seien Klimaschützer? Ach so! Na dann ist es gut. Das kann schon mal passieren.
September 9, 2025 at 2:05 PM
Sie haben friedliche Menschen gewaltsam attackiert! Was haben Sie zu Ihrer Verteidigung zu sagen? Ach? Sie dachten, das seien Klimaschützer? Ach so! Na dann ist es gut. Das kann schon mal passieren.
The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion.
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...
Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex
Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...
journals.plos.org
September 10, 2025 at 6:57 AM
The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion.
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...
Congratulations to Philip, Salome and Bernd
#mitochondria #mtDNA #Trypanosoma
journals.plos.org/plospathogen...
Reposted by André Schneider, University of Bern
Anna's hummingbird in my yard moments ago. #DavisCA, #birds, #wildlife #birdphotography #hummingbirds #NikonD500
September 4, 2025 at 12:51 AM
Anna's hummingbird in my yard moments ago. #DavisCA, #birds, #wildlife #birdphotography #hummingbirds #NikonD500
Reposted by André Schneider, University of Bern
🎊The Front Cover Art for our recent paper: A View on Molecular Complexity from the GDB Chemical Space
@yebuehler.bsky.social and Jean-Louis Reymond is now out @JCIM!
👉 tinyurl.com/yc4ufsfw
@acs.org @pubs.acs.org @unibe.ch @DCBPunibern
#MyACSCover #chemicalspace #drugdiscovery #molecules
@yebuehler.bsky.social and Jean-Louis Reymond is now out @JCIM!
👉 tinyurl.com/yc4ufsfw
@acs.org @pubs.acs.org @unibe.ch @DCBPunibern
#MyACSCover #chemicalspace #drugdiscovery #molecules
September 5, 2025 at 7:59 AM
🎊The Front Cover Art for our recent paper: A View on Molecular Complexity from the GDB Chemical Space
@yebuehler.bsky.social and Jean-Louis Reymond is now out @JCIM!
👉 tinyurl.com/yc4ufsfw
@acs.org @pubs.acs.org @unibe.ch @DCBPunibern
#MyACSCover #chemicalspace #drugdiscovery #molecules
@yebuehler.bsky.social and Jean-Louis Reymond is now out @JCIM!
👉 tinyurl.com/yc4ufsfw
@acs.org @pubs.acs.org @unibe.ch @DCBPunibern
#MyACSCover #chemicalspace #drugdiscovery #molecules
Reposted by André Schneider, University of Bern
Reposted by André Schneider, University of Bern
Dem Menschen, der dafür verantwortlich ist, dass Microsoft Word "DNA" automatisch auf "DANN" ausbessert, wünsche ich von Herzen, dass alle seine fallengelassenen Marmeladebrote mit der bestrichenen Seite nach unten auf dem Boden aufkommen.
August 23, 2025 at 2:29 PM
Dem Menschen, der dafür verantwortlich ist, dass Microsoft Word "DNA" automatisch auf "DANN" ausbessert, wünsche ich von Herzen, dass alle seine fallengelassenen Marmeladebrote mit der bestrichenen Seite nach unten auf dem Boden aufkommen.
Reposted by André Schneider, University of Bern
Dialog with society about phage therapy - our Agora project is taking off! Getting ready for lots of events across the country (D/FR): phagenforum.ch 💊🎙️🇨🇭
August 20, 2025 at 6:59 PM
Dialog with society about phage therapy - our Agora project is taking off! Getting ready for lots of events across the country (D/FR): phagenforum.ch 💊🎙️🇨🇭
Reposted by André Schneider, University of Bern
I may be in a world of hurt from my bike accident Sunday ... but I can't help sharing bird pics. Here is a gif I made of pics of a broad tailed hummingbird from my trip to Arizona last week. #birds
August 20, 2025 at 2:29 PM
I may be in a world of hurt from my bike accident Sunday ... but I can't help sharing bird pics. Here is a gif I made of pics of a broad tailed hummingbird from my trip to Arizona last week. #birds
Reposted by André Schneider, University of Bern
The movie about phage therapy in Switzerland and beyond is available online now 🍿🎬💊 - link to the English version here: www.youtube.com/watch?v=jUMJ...
August 20, 2025 at 2:34 PM
The movie about phage therapy in Switzerland and beyond is available online now 🍿🎬💊 - link to the English version here: www.youtube.com/watch?v=jUMJ...
Reposted by André Schneider, University of Bern
one small consolation of being a 60+ year old investigator is the ability to submit to 𝘔𝘈𝘛𝘜𝘙𝘌 family journals — sure they’re low impact (for our knees) but they have an early bird special if you submit between 4:00 and 5:30 on weekdays
August 14, 2025 at 12:32 AM
one small consolation of being a 60+ year old investigator is the ability to submit to 𝘔𝘈𝘛𝘜𝘙𝘌 family journals — sure they’re low impact (for our knees) but they have an early bird special if you submit between 4:00 and 5:30 on weekdays