Schlisio_lab
@schlisio-lab.bsky.social
🙏 With fantastic collaborators incl. @ChrisJuhlin, @MichaelMints & team!
#PPGL #CancerResearch #TumorOrigin #StemCells #SingleCell
#PPGL #CancerResearch #TumorOrigin #StemCells #SingleCell
July 22, 2025 at 1:11 PM
🙏 With fantastic collaborators incl. @ChrisJuhlin, @MichaelMints & team!
#PPGL #CancerResearch #TumorOrigin #StemCells #SingleCell
#PPGL #CancerResearch #TumorOrigin #StemCells #SingleCell
5/ DLK1-NOTCH signaling emerges as a key axis in chromaffin–sustentacular cell communication. DLK1 may act as a therapeutic vulnerability in PPGL.
July 22, 2025 at 1:11 PM
5/ DLK1-NOTCH signaling emerges as a key axis in chromaffin–sustentacular cell communication. DLK1 may act as a therapeutic vulnerability in PPGL.
4/ Some PPGL shows widespread SOX2 in PHOX2B+ tumor cells, linking SOX2 to stem-like states & impaired differentiation via ASCL1.
July 22, 2025 at 1:11 PM
4/ Some PPGL shows widespread SOX2 in PHOX2B+ tumor cells, linking SOX2 to stem-like states & impaired differentiation via ASCL1.
3/ In VHL-mutated paragangliomas, a subset of these sustentacular cells carries 3p loss—the hallmark of tumor cells—suggesting a shared clonal origin.
July 22, 2025 at 1:11 PM
3/ In VHL-mutated paragangliomas, a subset of these sustentacular cells carries 3p loss—the hallmark of tumor cells—suggesting a shared clonal origin.
2/ These cells are distinct from embryonic neural crest and Schwann cell precursors and exhibit a unique progenitor signature, verified by in vivo lineage tracing & snRNA-seq.
July 22, 2025 at 1:11 PM
2/ These cells are distinct from embryonic neural crest and Schwann cell precursors and exhibit a unique progenitor signature, verified by in vivo lineage tracing & snRNA-seq.
1/ We identify SOX2+/SOX10+ sustentacular glia-like cells in mouse and human adrenal medulla & organ of Zuckerkandl as postnatal chromaffin progenitors.
July 22, 2025 at 1:11 PM
1/ We identify SOX2+/SOX10+ sustentacular glia-like cells in mouse and human adrenal medulla & organ of Zuckerkandl as postnatal chromaffin progenitors.
Can support glia become cancer cells? Our study identifies SOX2⁺ postnatal chromaffin progenitors that may serve as tumor-initiating cells in paraganglioma. Figure 7 we inferring CNA from VHL related PPGL pre-neoplastic sustentacular cells sharing 3p deletions with tumor cells.
July 22, 2025 at 1:11 PM
Can support glia become cancer cells? Our study identifies SOX2⁺ postnatal chromaffin progenitors that may serve as tumor-initiating cells in paraganglioma. Figure 7 we inferring CNA from VHL related PPGL pre-neoplastic sustentacular cells sharing 3p deletions with tumor cells.
Beautiful work! Big congrats!
May 10, 2025 at 8:49 AM
Beautiful work! Big congrats!